DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2256 and USP32

DIOPT Version :9

Sequence 1:	NP_572437.2	Gene:	CG2256 / 31727	FlyBaseID:	FBgn0029995	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	XP_011523673.1	Gene:	USP32 / 84669	HGNCID:	19143	Length:	1634	Species:	Homo sapiens

Alignment Length:	313	Identity:	81/313 - (25%)
Similarity:	130/313 - (41%)	Gaps:	72/313 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GGTTGVGRSTLHANKTILKTVSVFLASGKRNSSNQQSKAAAAALQNK------RQQRQRRMDELS 105
            |||:    ..||.|..|:..  |.|..||   ..:::|...:...::      |::.:|.:..:.
Human    85 GGTS----KGLHFNNLIVGL--VLLTRGK---DEEKAKYIFSLFSSESGNYVIREEMERMLHVVD 140

  Fly   106 GKVNPKLLDSLRK------KTRFTKD------ELDALCRIYRKLVSNCQYAAKTLASSSSSAAIA 158
            |||.    |:|||      |..:.|.      ..||. ...|.|:|...|.  ||...|.:....
Human   141 GKVP----DTLRKCFSEGEKVNYEKFRNWLFLNKDAF-TFSRWLLSGGVYV--TLTDDSDTPTFY 198

  Fly   159 KPHAAVEGIDR--IVFRE----LLHS-----TFDIVT---------EEILMERIFCSWDKAHEGL 203
            :..|.|..::.  |:..|    ||.:     .||:.|         ...|.|.:|.::|:..:.
Human   199 QTLAGVTHLEESDIIDLEKRYWLLKAQSRTGRFDLETFGPLVSPPIRPSLSEGLFNAFDENRDN- 262

  Fly   204 PLRLEGWLIGLSTFLRGTPAERAAFCFRVYDLNTDGFITKDEMFTLLRNCLI------KQPQDED 262
            .:..:....|||...||..|||..|||:|:|::.||.:::.|    ||:.::      |..:.:|
Human   263 HIDFKEISCGLSACCRGPLAERQKFCFKVFDVDRDGVLSRVE----LRDMVVALLEVWKDNRTDD 323

  Fly   263 PDE---GVKDLVEIVLKKFDLDKDGKVSLEDF----MGTVTAEPLLIEAFGQC 308
            ..|   .:.|:||.:|...|..|.|.::|||:    :..|.|...|...|..|
Human   324 IPELHMDLSDIVEGILNAHDTTKMGHLTLEDYQIWSVKNVLANEFLNLLFQVC 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2256	NP_572437.2	EFh	228..292	CDD:238008	23/76 (30%)
CG2256	NP_572437.2	EF-hand_7	229..292	CDD:290234	22/75 (29%)
USP32	XP_011523673.1	EF-hand_7	252..309	CDD:290234	20/61 (33%)
		EFh	253..309	CDD:238008	20/60 (33%)
		EF-hand_7	286..358	CDD:290234	23/75 (31%)
		UBP12	534..1346	CDD:227847
		DUSP	<535..602	CDD:283896
		Ubiquitin_3	653..740	CDD:291502
		Peptidase_C19	765..>955	CDD:271592
		Peptidase_C19	<1255..1595	CDD:271592
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900