Protein Alignment CG2256 and KCNIP4

DIOPT Version :10

• Sequence 1: NP_572437.2
• Gene: CG2256 / 31727
• FlyBaseID: FBgn0029995
• Length: 324
• Species: Drosophila melanogaster
• Sequence 2: NP_079497.2
• Gene: KCNIP4 / 80333
• HGNCID: 30083
• Length: 250
• Species: Homo sapiens
• Alignment Length: 260
• Identity: 67/260 - (25%)
• Similarity: 114/260 - (43%)
• Gaps: 57/260 - (21%)

  Fly    44 TATGGTTGVGRSTLHANK-TILKTVSVFLASGKRNSSNQQSKAAAAALQNKRQQRQRRMDEL--- 104
            ::|||......||..:.| .::|.:....|           |.::.|:||..:      |||
Human    17 SSTGGFLYAQNSTKRSIKERLMKLLPCSAA-----------KTSSPAIQNSVE------DELEMA 64

  Fly   105 SGKVNPKLLDSLRKKTRFTKDELDALCRIYRKLVSNCQYAAKTLASSSSSAAIAKPHAAVEGIDR 169
            :.:..|:.|:.|..:::|||.||..|   ||...:.|                  |...|   :.
Human    65 TVRHRPEALELLEAQSKFTKKELQIL---YRGFKNEC------------------PSGVV---NE 105

  Fly   170 IVFRELLHSTFDIVTEEILMERIFCSWDKAHEGLPLRLEGWLIGLSTFLRGTPAERAAFCFRVYD 234
            ..|:|:....|...........:|.::|..|.| .:..|.::.|||..||||..|:..:.|.:||
Human   106 ETFKEIYSQFFPQGDSTTYAHFLFNAFDTDHNG-AVSFEDFIKGLSILLRGTVQEKLNWAFNLYD 169

  Fly   235 LNTDGFITKDEMFTLLR-------NCLIKQPQDEDPDEGVKDLVEIVLKKFDLDKDGKVSLEDFM 292
            :|.||:|||:||..:::       .|.....:::.|    :..||...:|.|.:|||.|::::|:
Human   170 INKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAP----RQHVETFFQKMDKNKDGVVTIDEFI 230

  Fly   293  292
            Human   231  230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2256	NP_572437.2	PRK12309	<103..290	CDD:183426	53/196 (27%)
		EF-hand_7	224..292	CDD:463900	22/74 (30%)
KCNIP4	NP_079497.2	KIS. /evidence=ECO:0000250|UniProtKB:Q6PHZ8	2..44		7/26 (27%)
		EF-hand_8	99..146	CDD:404678	10/50 (20%)
		FRQ1	<128..235	CDD:444056	35/108 (32%)
		Interaction with KCND2. /evidence=ECO:0000250|UniProtKB:Q8R426	237..250