DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2256 and efcab1

DIOPT Version :9

Sequence 1:	NP_572437.2	Gene:	CG2256 / 31727	FlyBaseID:	FBgn0029995	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_001038325.1	Gene:	efcab1 / 558421	ZFINID:	ZDB-GENE-040914-40	Length:	216	Species:	Danio rerio

Alignment Length:	220	Identity:	92/220 - (41%)
Similarity:	135/220 - (61%)	Gaps:	20/220 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 RMDELSGKVNPKLLDSL-RKKTRFTKDELDALCRIYRKLVSNCQYAAKTLASSSSSAAIAKPHAA 163
            :|..::.|:...|.::| |:...|.|.|.:.|.|::..|:.. |...||..
Zfish     3 KMSAMNRKLIQNLAETLCRQVKHFNKTETECLIRLFNSLLGE-QAERKTTI-------------- 52

  Fly   164 VEGIDRIVFRELLHSTFDIVTEEILMERIFCSWDKAHEGLPLRLEGWLIGLSTFLRGTPAERAAF 228
              |:||..||.:||.||. :|::::.:|:....||.::|. |.::.|:..||.|||||..|:..:
Zfish    53 --GVDRAKFRNILHHTFG-MTDDMMTDRVCRVIDKDNDGY-LSVKEWVEALSVFLRGTLDEKMKY 113

  Fly   229 CFRVYDLNTDGFITKDEMFTLLRNCLIKQPQDEDPDEGVKDLVEIVLKKFDLDKDGKVSLEDFMG 293
            ||.|||||.||:|:::|||.:|::.||:||.:||||||:||:|||.|||.|.|.||:||..||..
Zfish   114 CFEVYDLNGDGYISREEMFQMLKDSLIRQPTEEDPDEGIKDIVEIALKKMDYDHDGRVSYADFEK 178

  Fly   294 TVTAEPLLIEAFGQCLPTDSAVVSF 318
            ||..|.||:||||.|||...:|::|
Zfish   179 TVMDENLLLEAFGNCLPDAKSVLAF 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2256	NP_572437.2	EFh	228..292	CDD:238008	39/63 (62%)
CG2256	NP_572437.2	EF-hand_7	229..292	CDD:290234	39/62 (63%)
efcab1	NP_001038325.1	EFh	80..136	CDD:238008	26/56 (46%)
		EF-hand_7	80..135	CDD:290234	26/55 (47%)
		EFh	110..176	CDD:238008	38/65 (58%)
		EF-hand_7	111..178	CDD:290234	40/66 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7477
eggNOG	1	0.900	-	-		E2759_KOG0044
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11608
Inparanoid	1	1.050	164	1.000	Inparanoid score	I4174
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1331864at2759
OrthoFinder	1	1.000	-	-		FOG0005764
OrthoInspector	1	1.000	-	-		oto41512
orthoMCL	1	0.900	-	-		OOG6_107931
Panther	1	1.100	-	-	O	PTHR23055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5830
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.860