Protein Alignment Ldsdh1 and HSD17B6

DIOPT Version :10

• Sequence 1: NP_572436.1
• Gene: Ldsdh1 / 31726
• FlyBaseID: FBgn0029994
• Length: 320
• Species: Drosophila melanogaster
• Sequence 2: NP_003716.2
• Gene: HSD17B6 / 8630
• HGNCID: 23316
• Length: 317
• Species: Homo sapiens
• Alignment Length: 272
• Identity: 69/272 - (25%)
• Similarity: 111/272 - (40%)
• Gaps: 60/272 - (22%)

  Fly    37 WLAIAEAIVGLF-------RAPPLDDVNGKVVLITGTGHGMGKEMALQYAKLGATILCWDVN--- 91
            ||.:| |.|||:       ....:..:..|.|.|||...|.|..:|.|....|..:|...:.
Human     2 WLYLA-AFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKG 65

  Fly    92 -EQTNNQTVKEIKNNGGKAFGYVCNVTKREELIELAQKVRKEHGFIHV-------VVNNAGIMPC 148
             ||...||...::.       ...:|||.|.:....|.|::     ||       :||||||:..
Human    66 AEQLRGQTSDRLET-------VTLDVTKMESIAAATQWVKE-----HVGDRGLWGLVNNAGILTP 118

  Fly   149 HPLLE--HTENEIRLMYEINVLSHFWIIQAFLPDMIERNEGSIVALSSCAGLFGLINLVPYCGTK 211
            ..|.|  :||:.:. |.::|::....:..:.|| ::.|..|.||.:||..|..... :..||.:|
Human   119 ITLCEWLNTEDSMN-MLKVNLIGVIQVTLSMLP-LVRRARGRIVNVSSILGRVAFF-VGGYCVSK 180

  Fly   212 FAVRGYMAALVEELRQKNPQNNVKLTTIYPYMIDTGLCKNPRYRFPNLFKLIPADVAAGSIIEAQ 276
            :.|.    |..:.||::.....||::.:.|....||:....:                  .:|..
Human   181 YGVE----AFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQ------------------SLERM 223

  Fly   277 RQGLEEAAIPRH 288
            :|..:||  |:|
Human   224 KQSWKEA--PKH 233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ldsdh1	NP_572436.1	Rossmann-fold NAD(P)(+)-binding proteins	60..287	CDD:473865	59/239 (25%)
HSD17B6	NP_003716.2	type2_17beta_HSD-like_SDR_c	30..306	CDD:187665	62/243 (26%)