DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ldsdh1 and HSD17B12

DIOPT Version :10

Sequence 1:NP_572436.1 Gene:Ldsdh1 / 31726 FlyBaseID:FBgn0029994 Length:320 Species:Drosophila melanogaster
Sequence 2:NP_057226.1 Gene:HSD17B12 / 51144 HGNCID:18646 Length:312 Species:Homo sapiens


Alignment Length:252 Identity:72/252 - (28%)
Similarity:113/252 - (44%) Gaps:38/252 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 VKFWLAIAEAIVGLFRAPPLDDVNGKVVLITGTGHGMGKEMALQYAKLGATILCWDVNEQTNNQT 98
            ::.|....||.||    |.|    |:..::||:..|:||..|.:.||.|..::....::...:|.
Human    34 LRVWGVGNEAGVG----PGL----GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQV 90

  Fly    99 VKEIKNNGGKAFGYVCNVTKREELIELA-----QKVRKEHGF----IHVVVNNAGIMPCHPL--- 151
            ..|||..        ..|..|...::.|     .|::.  |.    |.::|||.|:...:|.   
Human    91 SSEIKEK--------FKVETRTIAVDFASEDIYDKIKT--GLAGLEIGILVNNVGMSYEYPEYFL 145

  Fly   152 -LEHTENEIRLMYEINVLSHFWIIQAFLPDMIERNEGSIVALSSCAGLFGLINLVPYCGTKFAVR 215
             :...:|.|:.|..||:||...:.|..||.|:||::|:|:.:||.:|:..:..|..|..||..|.
Human   146 DVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVD 210

  Fly   216 GYMAALVEELRQKNPQNNVKLTTIYPYMIDTGLCKNPRYRFPNLFKLIPADVAAGSI 272
            .:...|.||.|.|    .|.:.::.||.:.|.|.|   .|.|.|.|..|......:|
Human   211 FFSQCLHEEYRSK----GVFVQSVLPYFVATKLAK---IRKPTLDKPSPETFVKSAI 260

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ldsdh1NP_572436.1 Rossmann-fold NAD(P)(+)-binding proteins 60..287 CDD:473865 64/226 (28%)
HSD17B12NP_057226.1 17beta-HSD1_like_SDR_c 50..289 CDD:187614 65/228 (29%)
Di-lysine motif 308..312
Blue background indicates that the domain is not in the aligned region.

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