DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ldsdh1 and dhrs3a

DIOPT Version :9

Sequence 1:	NP_572436.1	Gene:	Ldsdh1 / 31726	FlyBaseID:	FBgn0029994	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_001003477.1	Gene:	dhrs3a / 445083	ZFINID:	ZDB-GENE-040801-217	Length:	302	Species:	Danio rerio

Alignment Length:	275	Identity:	84/275 - (30%)
Similarity:	142/275 - (51%)	Gaps:	8/275 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 AIAEAIVGLFRAPPLDDVNGKVVLITGTGHGMGKEMALQYAKLGA-TILCWDVNEQTNNQTVKEI 102
            :|.:|.|..|......|:...||||||.|.|:|:.:|.::||.|| .::.|...|:...:|.:||
Zfish    19 SILKATVRFFTRQKRRDLGTDVVLITGGGRGIGRHLAKEFAKQGARKVILWGRTEKCLKETCEEI 83

  Fly   103 KNNGGKAFGYVCNVTKREELIELAQKVRKEHGFIHVVVNNAGIMPCHPLLEHTENEIRLMYEINV 167
            ...|.:...:||:|..|||:.:.|:.:|::.|.:.::||||.::....|:|..::.:.....||.
Zfish    84 SMTGTECHYFVCDVGNREEVYQQAKVLREKVGDVTILVNNAAVVHGKSLMESDDDALLKTQHINT 148

  Fly   168 LSHFWIIQAFLPDMIERNEGSIVALSSCAGLFGLINLVPYCGTKFAVRGYMAALVEELRQKNPQN 232
            |..||..:||||.|:|...|.:|.::|...|..:...:.||.:|.:...:|.:|...|..   ..
Zfish   149 LGQFWTTKAFLPRMLELCNGHVVCINSILSLSSIPGAIDYCTSKASSYAFMESLTLGLLD---CP 210

  Fly   233 NVKLTTIYPYMIDTGLCKNPRYRFPNLFKLIPADVAAGSIIEAQRQGLEEAAIP--RHFVAAEKI 295
            .|..||:.|:..||.:.:..|.|||.||..:..::.|...::|.|.......:|  .||:...|
Zfish   211 GVGCTTVLPFHTDTEMFQGMRVRFPKLFPPLNPEMVAERTVDAVRTNTAFVVLPWTMHFLVILK- 274

  Fly   296 GRLIPRKAMRLVNDF 310
             .|:|:.|:..::.|
Zfish   275 -SLLPQSALEEIHKF 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ldsdh1	NP_572436.1	adh_short	59..248	CDD:278532	62/189 (33%)
Ldsdh1	NP_572436.1	NADB_Rossmann	60..287	CDD:304358	72/229 (31%)
dhrs3a	NP_001003477.1	PRK09072	41..291	CDD:236372	78/253 (31%)
dhrs3a	NP_001003477.1	17beta-HSDXI-like_SDR_c	53..281	CDD:187598	68/232 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1201
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1373099at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24322
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920