Protein Alignment Ldsdh1 and HSD17B2

DIOPT Version :10

• Sequence 1: NP_572436.1
• Gene: Ldsdh1 / 31726
• FlyBaseID: FBgn0029994
• Length: 320
• Species: Drosophila melanogaster
• Sequence 2: NP_002144.1
• Gene: HSD17B2 / 3294
• HGNCID: 5211
• Length: 387
• Species: Homo sapiens
• Alignment Length: 198
• Identity: 49/198 - (24%)
• Similarity: 93/198 - (46%)
• Gaps: 27/198 - (13%)

  Fly    56 VNGKVVLITGTGHGMGKEMALQYAKLGATILCWDVNEQTNNQTVKEIKNNGGKAFGYV-CNVTKR 119
            |:.|.||:||...|:|..:.....:||.|:....:||  |....:|::.........: .::||.
Human    80 VDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNE--NGPGAEELRRTCSPRLSVLQMDITKP 142

  Fly   120 EELIELAQKVR---KEHGFIHVVVNNAGIM--PCHPLLEHTENEIRLMYE------INVLSHFWI 173
            .::.:...||.   ::.| :..|:||||::  |       |:.|:.||.:      :|......:
Human   143 VQIKDAYSKVAAMLQDRG-LWAVINNAGVLGFP-------TDGELLLMTDYKQCMAVNFFGTVEV 199

  Fly   174 IQAFLPDMIERNEGSIVALSSCAGLFGLINLVPYCGTKFAVRGYMAALVEELRQKNPQNNVKLTT 238
            .:.||| ::.:::|.:|.:||..|...:..|..|..:|.||..:.:.:..||.:.    .:|:.:
Human   200 TKTFLP-LLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKW----GIKVAS 259

  Fly   239 IYP 241
            |.|
Human   260 IQP 262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ldsdh1	NP_572436.1	Rossmann-fold NAD(P)(+)-binding proteins	60..287	CDD:473865	47/194 (24%)
HSD17B2	NP_002144.1	type2_17beta_HSD-like_SDR_c	83..362	CDD:187665	48/195 (25%)