Protein Alignment Ldsdh1 and HSD17B3

DIOPT Version :10

• Sequence 1: NP_572436.1
• Gene: Ldsdh1 / 31726
• FlyBaseID: FBgn0029994
• Length: 320
• Species: Drosophila melanogaster
• Sequence 2: NP_000188.1
• Gene: HSD17B3 / 3293
• HGNCID: 5212
• Length: 310
• Species: Homo sapiens
• Alignment Length: 225
• Identity: 54/225 - (24%)
• Similarity: 99/225 - (44%)
• Gaps: 24/225 - (10%)

  Fly    32 LIVKFWLAIAEAIVGLFRAPPLDDVNGKVVLITGTGHGMGKEMALQYAKLGATILCWDVNEQTNN 96
            :::.:|..:.::.:...         |:..:|||.|.|:||..:.:.||.|..::......:...
Human    31 VLLNYWKVLPKSFLRSM---------GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLE 86

  Fly    97 QTVKEIKNNGGKAFGYV-CNVTKREELIELAQKVRKEHGF-IHVVVNNAG----IMPCHPLLEHT 155
            ....||:...|::...: .:.||.:....:.:|:.   |. |.::|||.|    ::|.|.|  :.
Human    87 AIATEIERTTGRSVKIIQADFTKDDIYEHIKEKLA---GLEIGILVNNVGMLPNLLPSHFL--NA 146

  Fly   156 ENEIRLMYEINVLSHFWIIQAFLPDMIERNEGSIVALSSCAGLFGLINLVPYCGTKFAVRGYMAA 220
            .:||:.:...|:.|...:.|..|..|..|.:|.|:.:||...||.......|..:|..|..:..|
Human   147 PDEIQSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKA 211

  Fly   221 LVEELRQKNPQNNVKLTTIYPYMIDTGLCK 250
            |.||.:.|    .|.:..:.||.:.|.:.|
Human   212 LQEEYKAK----EVIIQVLTPYAVSTAMTK 237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ldsdh1	NP_572436.1	Rossmann-fold NAD(P)(+)-binding proteins	60..287	CDD:473865	52/197 (26%)
HSD17B3	NP_000188.1	17beta-HSD1_like_SDR_c	48..284	CDD:187614	53/199 (27%)