DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ldsdh1 and HSD11B2

DIOPT Version :10

Sequence 1:NP_572436.1 Gene:Ldsdh1 / 31726 FlyBaseID:FBgn0029994 Length:320 Species:Drosophila melanogaster
Sequence 2:NP_000187.3 Gene:HSD11B2 / 3291 HGNCID:5209 Length:405 Species:Homo sapiens


Alignment Length:362 Identity:71/362 - (19%)
Similarity:116/362 - (32%) Gaps:134/362 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 IVMLIVKFWLAIAEAIVGLFRAPPLDDVNGKVVLITGTGHGMGKEMALQYAKLGATILCWDVNEQ 93
            :.:|....|:|::.     ...|....|..:.|||||...|.|||.|.:...:|.|:|.      
Human    58 LAVLAAAGWIALSR-----LARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLA------ 111

  Fly    94 TNNQTVKEIKNNGGKAFGYVC---------NVTKREELIELAQ--KVRKEHGFIHVVVNNAGIMP 147
                ||.|:.:.|.......|         ::||..::..:.:  |.......:..:|||||   
Human   112 ----TVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAG--- 169

  Fly   148 CHPLLEHTENEI------------RLMYEINVLSHFWIIQAFLPDMIERNEGSIVALSS------ 194
                    .||:            |...|:|......:.:..|| ::..:.|.||.:.|      
Human   170 --------HNEVVADAELSPVATFRSCMEVNFFGALELTKGLLP-LLRSSRGRIVTVGSPAGDMP 225

  Fly   195 --CAGLFGL----------------------INLV-PYCGTKFAVRG----------YMAALVEE 224
              |.|.:|.                      :::: |.|....:||.          .:|.|.:|
Human   226 YPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQE 290

  Fly   225 LRQKNPQNNVK----------------LTTIYPYMIDTGLCKNPRYRFPNLFKLIPADVAAGSII 273
            |.|...::.::                ||.:...:.|..|...||.|:      .|.        
Human   291 LLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRY------YPG-------- 341

  Fly   274 EAQRQGLE---------EAAIPRHFVAAEKIGRLIPR 301
                |||.         ...:.|.|:.|..|...:||
Human   342 ----QGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPR 374

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ldsdh1NP_572436.1 Rossmann-fold NAD(P)(+)-binding proteins 60..287 CDD:473865 60/315 (19%)
HSD11B2NP_000187.3 type2_17beta_HSD-like_SDR_c 83..363 CDD:187665 61/319 (19%)
Essential for protein stability 335..339 2/9 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 377..405
Blue background indicates that the domain is not in the aligned region.

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