Protein Alignment Ldsdh1 and Dhrs3

DIOPT Version :10

• Sequence 1: NP_572436.1
• Gene: Ldsdh1 / 31726
• FlyBaseID: FBgn0029994
• Length: 320
• Species: Drosophila melanogaster
• Sequence 2: NP_035433.1
• Gene: Dhrs3 / 20148
• MGIID: 1315215
• Length: 302
• Species: Mus musculus
• Alignment Length: 293
• Identity: 85/293 - (29%)
• Similarity: 152/293 - (51%)
• Gaps: 11/293 - (3%)

  Fly    22 IVLLVVDIVMLIVKFWLAIAEAIVGLFRAPPLDDVNGKVVLITGTGHGMGKEMALQYAKLGA-TI 85
            :|:..:.::.|:.|       |.||:...|.|.|::.:.|||||.|.|:|:.:|.::|:.|| .|
Mouse     9 LVVFPLQMIYLVTK-------AAVGMVLPPKLRDLSRESVLITGGGRGIGRHLAREFAERGARKI 66

  Fly    86 LCWDVNEQTNNQTVKEIKNNGGKAFGYVCNVTKREELIELAQKVRKEHGFIHVVVNNAGIMPCHP 150
            :.|...|:...:|.:||:..|.:...::|:|..|||:.::|:.||::.|.|.::||||.::....
Mouse    67 VLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQMAKAVREKVGDITILVNNAAVVHGKS 131

  Fly   151 LLEHTENEIRLMYEINVLSHFWIIQAFLPDMIERNEGSIVALSSCAGLFGLINLVPYCGTKFAVR 215
            |::..::.:.....:|.|..||..:||||.|:|...|.||.|:|...|..:...:.||.:|.:..
Mouse   132 LMDSDDDALLKSQHVNTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAF 196

  Fly   216 GYMAALVEELRQKNPQNNVKLTTIYPYMIDTGLCKNPRYRFPNLFKLIPADVAAGSIIEAQRQGL 280
            .:|.:|...|..   ...|..||:.|:...|.:.:..|.||||||..:..:..|...::|.:|..
Mouse   197 AFMESLTLGLLD---CPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVDAVQQNQ 258

  Fly   281 EEAAIPRHFVAAEKIGRLIPRKAMRLVNDFFDT 313
            ....:|........:..::|:.|:..::.|..|
Mouse   259 ALLLLPWTMNILIILKSILPQAALEEIHRFSGT 291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ldsdh1	NP_572436.1	Rossmann-fold NAD(P)(+)-binding proteins	60..287	CDD:473865	71/227 (31%)
Dhrs3	NP_035433.1	17beta-HSDXI-like_SDR_c	53..281	CDD:187598	65/230 (28%)