DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ldsdh1 and dhs-29

DIOPT Version :9

Sequence 1:	NP_572436.1	Gene:	Ldsdh1 / 31726	FlyBaseID:	FBgn0029994	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_509294.1	Gene:	dhs-29 / 181027	WormBaseID:	WBGene00000992	Length:	427	Species:	Caenorhabditis elegans

Alignment Length:	222	Identity:	75/222 - (33%)
Similarity:	120/222 - (54%)	Gaps:	11/222 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KFWLAIAEAIVGLFRAPPLD----------DVNGKVVLITGTGHGMGKEMALQYAKLGATILCWD 89
            |.|..:..|:..||...|:|          .|.|:.|:|||.|.|:|:.|||.:||..|.:...|
Worm     8 KLWSTLGVALRILFIDIPMDIHRFLNLRQKSVQGQTVIITGGGSGLGRAMALDFAKRKAKVAIID 72

  Fly    90 VNEQTNNQTVKEIKNNGGKAFGYVCNVTKREELIELAQKVRKEHGFIHVVVNNAGIMPCHPLLEH 154
            ||::...:|||.|...|..|..:.|:::..:.:.:.|:::....|.:::|:.||.|:.....:|.
Worm    73 VNKEGGLETVKTIAAEGNMAKFWYCDISDVDNMKKTAKEIEDTFGDVNIVICNAAILSFTSFMEI 137

  Fly   155 TENEIRLMYEINVLSHFWIIQAFLPDMIERNEGSIVALSSCAGLFGLINLVPYCGTKFAVRGYMA 219
            ::..:|...::|:......|:||||.|..:|:|.||.:.|.||..|....:.||.:||||||.|.
Worm   138 SDELLRKCLDVNIFGTINTIRAFLPKMETKNDGHIVCVCSIAGWSGETMGLSYCTSKFAVRGAME 202

  Fly   220 ALVEELRQKNPQNNVKLTTIYPYMIDT 246
            :|..|||.:..: .:|.||:|||...|
Worm   203 SLQMELRDRGLE-GIKTTTLYPYFART 228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ldsdh1	NP_572436.1	adh_short	59..248	CDD:278532	66/188 (35%)
Ldsdh1	NP_572436.1	NADB_Rossmann	60..287	CDD:304358	66/187 (35%)
dhs-29	NP_509294.1	adh_short	42..230	CDD:278532	66/188 (35%)
		NADB_Rossmann	43..281	CDD:304358	66/187 (35%)
		DUF4499	322..416	CDD:291595
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1201
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1373099at2759
OrthoFinder	1	1.000	-	-		FOG0000227
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100599
Panther	1	1.100	-	-	O	PTHR24322
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7624
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.780