Protein Alignment Ldsdh1 and RDH10

DIOPT Version :10

• Sequence 1: NP_572436.1
• Gene: Ldsdh1 / 31726
• FlyBaseID: FBgn0029994
• Length: 320
• Species: Drosophila melanogaster
• Sequence 2: NP_742034.1
• Gene: RDH10 / 157506
• HGNCID: 19975
• Length: 341
• Species: Homo sapiens
• Alignment Length: 257
• Identity: 90/257 - (35%)
• Similarity: 138/257 - (53%)
• Gaps: 28/257 - (10%)

  Fly    25 LVVDIVMLIVK-FWLAIAEAIVGLFRAPPLDDVNGKVVLITGTGHGMGKEMALQYAKLGATILCW 88
            :||:..::..| .|..:..|...|.| |....|.|:|.||||.|.|:|:..||::|:..|.::.|
Human     3 IVVEFFVVTFKVLWAFVLAAARWLVR-PKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLW 66

  Fly    89 DVNEQTNNQTVKEIKN----------------NGG---------KAFGYVCNVTKREELIELAQK 128
            |:|.|:|.:|...:::                ||.         :.|.|.|:|.|||.:...|::
Human    67 DINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAER 131

  Fly   129 VRKEHGFIHVVVNNAGIMPCHPLLEHTENEIRLMYEINVLSHFWIIQAFLPDMIERNEGSIVALS 193
            ||||.|.:.|:|||||::..|.|||..:..|.....:|..:|||..:||||.|:|.|.|.||.::
Human   132 VRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVA 196

  Fly   194 SCAGLFGLINLVPYCGTKFAVRGYMAALVEELRQKNPQNNVKLTTIYPYMIDTGLCKNPRYR 255
            |..|||....:..||.:||.|.|:..:|..||:... ::.:|.|.:.||::|||:.:..|.|
Human   197 SSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAE-KDGIKTTLVCPYLVDTGMFRGCRIR 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ldsdh1	NP_572436.1	Rossmann-fold NAD(P)(+)-binding proteins	60..287	CDD:473865	80/221 (36%)
RDH10	NP_742034.1	17beta-HSDXI-like_SDR_c	38..307	CDD:187598	80/221 (36%)