Protein Alignment Ldsdh1 and Hsd17b11

DIOPT Version :10

• Sequence 1: NP_572436.1
• Gene: Ldsdh1 / 31726
• FlyBaseID: FBgn0029994
• Length: 320
• Species: Drosophila melanogaster
• Sequence 2: NP_444492.1
• Gene: Hsd17b11 / 114664
• MGIID: 2149821
• Length: 298
• Species: Mus musculus
• Alignment Length: 298
• Identity: 92/298 - (30%)
• Similarity: 163/298 - (54%)
• Gaps: 16/298 - (5%)

  Fly    26 VVDIVMLIVKFWLAIAEAIVGLFRAPPLDDVNGKVVLITGTGHGMGKEMALQYAKLGATILCWDV 90
            ::|:::|:....:...|::|.||.......|.|::|||||.|||:|:..|.::|||...::.||:
Mouse     4 LLDLILLLPLLIVFSIESLVKLFIPKKKKSVAGEIVLITGAGHGIGRLTAYEFAKLNTKLVLWDI 68

  Fly    91 NEQTNNQTVKEIKNNGGKAFGYVCNVTKREELIELAQKVRKEHGFIHVVVNNAGIMPCHPLLEHT 155
            |:....:|..:.:..|.:|..:|.:.::|||:...|:||::|.|.:.::|||||::....|....
Mouse    69 NKNGIEETAAKCRKLGAQAHPFVVDCSQREEIYSAAKKVKEEVGDVSILVNNAGVVYTADLFATQ 133

  Fly   156 ENEIRLMYEINVLSHFWIIQAFLPDMIERNEGSIVALSSCAGLFGLINLVPYCGTKFAVRGYMAA 220
            :.:|...:|:|||:|||..:||||.|::.|.|.||.::|.||...:..|:.||.:|||..|:..|
Mouse   134 DPQIEKTFEVNVLAHFWTTKAFLPVMMKNNHGHIVTVASAAGHTVVPFLLAYCSSKFAAVGFHRA 198

  Fly   221 LVEELRQKNPQNNVKLTTIYPYMIDTGLCKNPRYRFPNLFKLIPADVAAGSIIEAQRQGL----E 281
            |.:||.... :..|:.:.:.|..|:||..|||.   .||...:..:    .::|....|:    :
Mouse   199 LTDELAALG-RTGVRTSCLCPNFINTGFIKNPS---TNLGPTLEPE----EVVEHLMHGILTEKQ 255

  Fly   282 EAAIPRHFVAAEKIGRLIPRKAMRL----VNDFFDTGV 315
            ...:|........:.|::|.:.:::    :|..||..|
Mouse   256 MIFVPSSIALLTVLERIVPERFLQVLKHRINVKFDAVV 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ldsdh1	NP_572436.1	Rossmann-fold NAD(P)(+)-binding proteins	60..287	CDD:473865	77/230 (33%)
Hsd17b11	NP_444492.1	17beta-HSDXI-like_SDR_c	38..277	CDD:187598	80/246 (33%)