DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1571 and DYNC2I2

DIOPT Version :9

Sequence 1:NP_572435.1 Gene:CG1571 / 31725 FlyBaseID:FBgn0029993 Length:651 Species:Drosophila melanogaster
Sequence 2:NP_443076.2 Gene:DYNC2I2 / 89891 HGNCID:28296 Length:536 Species:Homo sapiens


Alignment Length:335 Identity:72/335 - (21%)
Similarity:127/335 - (37%) Gaps:51/335 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   211 WDV-KNPLKPRITYDSKQQVSLAKIC----PKDENNMVGGTGLGQVCLWGTFKGGLPI--RNCPL 268
            |:: :..|:|: ...:..:|..|.:|    |...:::.||...|:|.:|...:...|:  |....
Human   198 WNLDRRDLRPQ-QPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLEDPLLWRTGLT 261

  Fly   269 EVSHRETTSALCWVHSKSNT---EFYSGSLDGSIKYWD---------TRDLKMPMQELLLEPEPQ 321
            :.:|.:..|.:.|:....::   :..|.:.||.:..|.         |....:.||:|       
Human   262 DDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQGIGVGQLQLTEGFALVMQQL------- 319

  Fly   322 ERQSRMDSH-------GVTVLEFEYTIPVRFIIGSDMGH----VFVGNRKGMTPMET---LLAHY 372
            .|.:::..|       |.|.:.|....|..||:|::.|.    ........:|.|.:   |.|..
Human   320 PRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAPA 384

  Fly   373 QLFV----GPVRSINRNPFFVKNFLVTG-DWRARIWSEEVKDSPSTMYFRKNAQILCGAWSTGRC 432
            |...    ||:.|::.:||....||..| |....::| .::..|.|........:....||..|.
Human   385 QFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYS-MLQAPPLTSLQLSLKYLFAVRWSPVRP 448

  Fly   433 SLFVTGDINGVVDFWDLLLHHRKP---IRSVDFKVAIADLVFR-PEGDLLAIGLKNGDTHIMTLD 493
            .:|......|.|..:||....:||   |:....:..:..|.|. .:..|||.|...|...:..|.
Human   449 LVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGTVKVWQLS 513

  Fly   494 ESMRQATGKE 503
            ....:...:|
Human   514 TEFTEQGPRE 523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1571NP_572435.1 WD40 210..462 CDD:295369 63/291 (22%)
WD40 211..>488 CDD:225201 70/318 (22%)
WD40 repeat 229..269 CDD:293791 11/45 (24%)
WD40 repeat 277..325 CDD:293791 11/59 (19%)
WD40 repeat 332..369 CDD:293791 9/43 (21%)
WD40 repeat 379..415 CDD:293791 10/36 (28%)
WD40 repeat 422..447 CDD:293791 6/24 (25%)
DYNC2I2NP_443076.2 DYNLL2 binding. /evidence=ECO:0000269|PubMed:30649997 80..93
WD40 106..516 CDD:225201 71/326 (22%)
DYNLRB1 binding. /evidence=ECO:0000269|PubMed:30649997 106..131
WD40 repeat 164..215 CDD:293791 3/17 (18%)
WD 1. /evidence=ECO:0000255 215..255 10/39 (26%)
WD40 217..515 CDD:295369 67/305 (22%)
WD40 repeat 220..264 CDD:293791 9/43 (21%)
WD 2. /evidence=ECO:0000255 264..308 7/43 (16%)
WD40 repeat 270..325 CDD:293791 11/61 (18%)
WD40 repeat 337..389 CDD:293791 12/51 (24%)
WD 3. /evidence=ECO:0000255 390..430 11/40 (28%)
WD40 repeat 396..432 CDD:293791 10/36 (28%)
WD 4. /evidence=ECO:0000255 433..473 9/39 (23%)
WD40 repeat 438..476 CDD:293791 10/37 (27%)
WD 5. /evidence=ECO:0000255 480..520 8/39 (21%)
WD40 repeat 485..512 CDD:293791 7/26 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1587
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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