DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1571 and dnai1.2

DIOPT Version :9

Sequence 1:	NP_572435.1	Gene:	CG1571 / 31725	FlyBaseID:	FBgn0029993	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_001074027.1	Gene:	dnai1.2 / 555705	ZFINID:	ZDB-GENE-070112-1302	Length:	660	Species:	Danio rerio

Alignment Length:	601	Identity:	117/601 - (19%)
Similarity:	223/601 - (37%)	Gaps:	136/601 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DRNELMVSVHP-----SGRQRLKYIMANPSEKSTQLSRQMALTVMETENVTLDQHGMYHYEGGWP 82
            |....:::.|.     .|.:||:.:...|.::..:::.|  ...::..:.||:         ..|
Zfish   125 DEGRRLMAKHTEREDCGGDERLENVPIKPGKREQKVTNQ--FNFIDRASQTLN---------NLP 178

  Fly    83 KEVNFNDE---------------------EQTQRHRKKVEREDSW---GEQVLSMIRTTMSVAEQ 123
            :|::...|                     |:.||..|..|:::|.   .|:..|..:...:.|:.
Zfish   179 REISCQTEPPPRANFSATANQWEIYDFYVEELQRREKSKEKQESQFPNKEEDRSKKKMIQAEAQS 243

  Fly   124 NNTLN-----------IYQNFFADLPPELGH--DIKMRFRARVANVFHDLW------LPARQLRS 169
            ::...           :.||.|.::..:..:  |....||.....:. .||      .....:.:
Zfish   244 DDISQLAKPAEIIERMVNQNIFDEVAQDFMYFEDAADEFRGEKGTLL-PLWKFQYDKAKGLSVTA 307

  Fly   170 IEWMPNNSRQFMTQYTNHFAKGERLRPVTDEPFGGTNGFYVWDVKNPLKPRITYDSKQQVSLAKI 234
            :.|  |:.      |::.||.|......|.:. .|...||.  :|||..|...:::...|....|
Zfish   308 LCW--NHI------YSDLFAVGLGSYEFTQQE-RGMLLFYT--LKNPSFPEFIFNTDSGVMCVDI 361

  Fly   235 CPKDENNMVGGTGLGQVCLWGTF----KGGLPIRNCPLEVSHRETTSALCWVHSK-----SNTEF 290
              .::.:.:...||...|: ..:    |...|:.|.  ..|..:.|.|:..|..:     ||..|
Zfish   362 --HEQLSYLVAVGLYDGCV-SVYDLRKKSDQPMYNS--IASSGKHTGAVWQVKWQKDDLDSNHNF 421

  Fly   291 YSGSLDGSIKYWD--------TRDLKMPMQELLLEPEPQERQSRMDSHGVTVLEFEYTIPVRFII 347
            :|.|.||.:..|.        |..:|:|.    ::..|.:.::.:.:.| |.|:|.......|::
Zfish   422 FSVSTDGRVVSWTLVKHEIVFTDIIKLPP----VDKVPDDLKNVVATAG-TSLDFHKQKDHHFLV 481

  Fly   348 GSDMGHVFVGNRKGMTP-METLLAHYQLFVGPVRSINRNPFFVKNFLVTG-DWRARIWSEEVKDS 410
            |::.|.:..|::...:. :|...||:.    .|..:..|||....|:..| ||..:||...: :|
Zfish   482 GTEAGKIHKGSKYYSSKFLEMYDAHFM----TVSCVRWNPFHPNVFISCGWDWMVKIWDHTI-NS 541

  Fly   411 PSTMYFRKNAQILCGAWSTGRCSLFVTGDINGVVDFWDLLLHHRKPI---RSVDFKVAIADLVFR 472
            | ...|...:.:...|||....::|.....:|.|..:||.::..:.:   :.|..|..:..:.|.
Zfish   542 P-VFTFELKSSVTDVAWSPHSSTVFAAVTADGKVHVFDLSINKYEALCQQKVVSKKTRLLHIEFN 605

  Fly   473 PEGDLLAIGLKNGDTHIMTLDESMRQATGKEKALMAAMFEREIVRCKLLEARYDEVRLKRKTLQM 537
            |...::.:|...|....:.|..::|:.. |||                          |.:.|..
Zfish   606 PVHPIIIVGDDRGRVISLKLSPNLRKKP-KEK--------------------------KGQELPK 643

  Fly   538 AEEERVRKQQQLAPTL 553
            ..|..:.|.:||..:|
Zfish   644 GPEVEIAKMEQLLSSL 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1571	NP_572435.1	WD40	210..462	CDD:295369	61/273 (22%)
		WD40	211..>488	CDD:225201	66/298 (22%)
		WD40 repeat	229..269	CDD:293791	8/43 (19%)
		WD40 repeat	277..325	CDD:293791	14/60 (23%)
		WD40 repeat	332..369	CDD:293791	8/37 (22%)
		WD40 repeat	379..415	CDD:293791	12/36 (33%)
		WD40 repeat	422..447	CDD:293791	6/24 (25%)
dnai1.2	NP_001074027.1	WD40	<296..650	CDD:225201	84/407 (21%)
		WD40	354..620	CDD:295369	62/281 (22%)
		WD40 repeat	357..397	CDD:293791	7/44 (16%)
		WD40 repeat	405..485	CDD:293791	19/84 (23%)
		WD40 repeat	511..547	CDD:293791	11/37 (30%)
		WD40 repeat	552..591	CDD:293791	8/38 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810