DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1571 and DYNC2I1

DIOPT Version :9

Sequence 1:	NP_572435.1	Gene:	CG1571 / 31725	FlyBaseID:	FBgn0029993	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	XP_006716104.1	Gene:	DYNC2I1 / 55112	HGNCID:	21862	Length:	1069	Species:	Homo sapiens

Alignment Length:	617	Identity:	130/617 - (21%)
Similarity:	207/617 - (33%)	Gaps:	173/617 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 NELMVSVHPSGRQRLK--YIMANPSEKSTQLSRQMALTVMETENVTLDQHGMYHYEGGWPKEVNF 87
            ||..:.:...|::..|  |:..|    ...:.|.:....:||..|.....|......|..::.:.
Human   517 NEYDMYIRNFGKKNTKQAYVQCN----EDNVERDIQTEEIETREVWTQHPGESTVVSGGSEQRDT 577

  Fly    88 ND-----EEQTQR----------------HRKKVEREDSWGEQVLSMIRTTMSVAEQNNTLNIYQ 131
            :|     :..|.|                ...::..|.||            ::..|:..|
Human   578 SDAVVMPKIDTPRLCSFLRAACQVMAVLLEEDRLAAEPSW------------NLRAQDRAL---- 626

  Fly   132 NFFADLPPELGHDIKMRFRARVANVFHDLWLPARQLRSIEWMPNNSRQFMTQYTNHFAKGERLRP 196
             :|:|...:|...:......:|::: |...:..:.:.|:..:|..|  |:              |
Human   627 -YFSDSSSQLNTSLPFLQNRKVSSL-HTSRVQRQMVVSVHDLPEKS--FV--------------P 673

  Fly   197 VTDEPFGGTNGFYVWDVKNPLKPRITYDSKQQVSLAKICPKDENNMVGGTGLGQVCLWG------ 255
            :.|..:    ...|||:..|..|:.....:.||:...:.|.....:..||..|.|.:|.
Human   674 LLDSKY----VLCVWDIWQPSGPQKVLICESQVTCCCLSPLKAFLLFAGTAHGSVVVWDLREDSR 734

  Fly   256 -----TFKGGL-PIRNCPL-------EVSHRETTSAL----CWVHSK--------------SNTE 289
                 |...|. ..|....       .|:||....|:    ..||.|              |...
Human   735 LHYSVTLSDGFWTFRTATFSTDGILTSVNHRSPLQAVEPISTSVHKKQSFVLSPFSTQEEMSGLS 799

  Fly   290 FYSGSLD--GSIKYW-----DTRDLKMPMQELLLEPEPQERQSRMD--------SH------GVT 333
            |:..|||  |.:..|     ...|:...:.:|.|.|..:.:.....        ||      |.|
Human   800 FHIASLDESGVLNVWVVVELPKADIAGSISDLGLMPGGRVKLVHSALIQLGDSLSHKGNEFWGTT 864

  Fly   334 V---LEFEYTIPVRFIIGSDMGHVFVGNRKGMTPMETLLAHYQLFVGPVR--SINRNPFFVKNFL 393
            .   ::|..:.|..||||:|||.:..|.|:.:.....|....|..:.||:  .|:.:||....||
Human   865 QTLNVKFLPSDPNHFIIGTDMGLISHGTRQDLRVAPKLFKPQQHGIRPVKVNVIDFSPFGEPIFL 929

  Fly   394 V-TGDWRARI-----------WSEEVKDSPSTMYFRKNAQILCGAWSTGRCSLFVTGDINGVVDF 446
            . ..|...|:           |     ||.:..:.....|     ||..|.::|:..|....:..
Human   930 AGCSDGSIRLHQLSSAFPLLQW-----DSSTDSHAVTGLQ-----WSPTRPAVFLVQDDTSNIYI 984

  Fly   447 WDLLLHHRKPIR----SVDFKVAIADLVFRPE---GDLLAIGL--KNGDTHIMTLDESMRQATGK 502
            ||||.....|:.    |.:..||:| .|..||   |..||:.|  .:|...|..|
Human   985 WDLLQSDLGPVAKQQVSPNRLVAMA-AVGEPEKAGGSFLALVLARASGSIDIQHL---------- 1038

  Fly   503 EKALMAAMFEREIVRCKLL--EARYDEVRLKR 532
             |...||....|..|.:||  ||.:.|.:|.:
Human  1039 -KRRWAAPEVDECNRLRLLLQEALWPEGKLHK 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1571	NP_572435.1	WD40	210..462	CDD:295369	75/330 (23%)
		WD40	211..>488	CDD:225201	85/360 (24%)
		WD40 repeat	229..269	CDD:293791	10/58 (17%)
		WD40 repeat	277..325	CDD:293791	15/72 (21%)
		WD40 repeat	332..369	CDD:293791	12/39 (31%)
		WD40 repeat	379..415	CDD:293791	11/49 (22%)
		WD40 repeat	422..447	CDD:293791	5/24 (21%)
DYNC2I1	XP_006716104.1	WD40	630..1020	CDD:225201	91/421 (22%)
		WD40 repeat	648..676	CDD:293791	6/44 (14%)
		WD40 repeat	736..778	CDD:293791	7/41 (17%)
		WD40 repeat	785..814	CDD:293791	6/28 (21%)
		WD40 repeat	829..860	CDD:293791	5/30 (17%)
		WD40	<915..987	CDD:295369	17/81 (21%)
		WD40 repeat	916..952	CDD:293791	8/40 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810