DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1571 and sw

DIOPT Version :9

Sequence 1:	NP_572435.1	Gene:	CG1571 / 31725	FlyBaseID:	FBgn0029993	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_477075.2	Gene:	sw / 44160	FlyBaseID:	FBgn0003654	Length:	663	Species:	Drosophila melanogaster

Alignment Length:	474	Identity:	114/474 - (24%)
Similarity:	193/474 - (40%)	Gaps:	75/474 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 KEVNFNDEEQTQ------RHRKKVEREDSWGEQVLSMIRTTMSVAEQNNTLNIYQNFFADLPPEL 141
            ||||...|||.|      ..::.|.|.....|:.||            ..::||.::......|.
  Fly   237 KEVNELSEEQKQMIILSENFQRFVVRAGRVIERALS------------ENVDIYTDYIGGGDSEE 289

  Fly   142 GHDIKMRFRARVANVFHD-LWLPARQLRSIEWMPNNSRQFMTQYTNHFAKGERLRPVTDEPFGGT 205
            .:|.:...|..:..||:| .|...|.:.|::|..:.....:..|.|:       ....:||.|..
  Fly   290 ANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNN-------EESPNEPDGVV 347

  Fly   206 NGFYVWDVK-NPLKPRITYDSKQQVSLAKICPKDENNMVGGTGLGQVCLW-GTFKGGLPIRNCPL 268
               .||:.| ....|...:..:..|........:.|.::|||..||:.|| ...:...||:..||
  Fly   348 ---MVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPL 409

  Fly   269 E-VSHRETTSALCWVHSKSNTEFYSGSLDGSIKYWDTRDLKMPMQELLLEPEPQERQSRMDSHGV 332
            . .:|......|..|.:::.....|.|.||.:..|....|..|...|    |.|:|||:  :..:
  Fly   410 SAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTL----ELQQRQSK--AIAI 468

  Fly   333 TVLEFEYTIPVRFIIGSDMGHVFVGNRKGMTPMETLLAHYQLFVGPVRSINR-----NPFFVKNF 392
            |.:.|........::||:.|:|:..:|.|:  ...:...|:..:||:..|:.     :|.|...|
  Fly   469 TSMAFPANEINSLVMGSEDGYVYSASRHGL--RSGVNEVYERHLGPITGISTHYNQLSPDFGHLF 531

  Fly   393 LVTG-DWRARIWSEEVKDSPSTMYFRKNAQ-ILCGAWSTGRCSLFVTGDINGVVDFWDLLLHHRK 455
            |.:. ||..::||  :||:.....|..|:. ::..|||....:||...|.:|.:|.|:|
  Fly   532 LTSSIDWTIKLWS--LKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNL------ 588

  Fly   456 PIRSVDFKVAIADLV-----------FRPEGDLLAIGLKNGDTHIMTLDESMRQATGKEKALMAA 509
               :.|.:|..|.:|           :.|.|..:.||.:.|..::..:.|::.|.:..|    .:
  Fly   589 ---NQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDE----WS 646

  Fly   510 MFEREIVRCKLLEARYDEV 528
            .|...:...|:.::  |||
  Fly   647 RFNTHLSEIKMNQS--DEV 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1571	NP_572435.1	WD40	210..462	CDD:295369	67/261 (26%)
		WD40	211..>488	CDD:225201	75/297 (25%)
		WD40 repeat	229..269	CDD:293791	12/40 (30%)
		WD40 repeat	277..325	CDD:293791	13/47 (28%)
		WD40 repeat	332..369	CDD:293791	8/36 (22%)
		WD40 repeat	379..415	CDD:293791	11/41 (27%)
		WD40 repeat	422..447	CDD:293791	8/24 (33%)
sw	NP_477075.2	Dynein_IC2	107..135	CDD:402922
		WD40	316..632	CDD:421866	83/344 (24%)
		WD40 repeat	316..365	CDD:293791	11/58 (19%)
		WD40 repeat	371..409	CDD:293791	10/37 (27%)
		WD40 repeat	418..457	CDD:293791	10/42 (24%)
		WD40 repeat	469..555	CDD:293791	22/89 (25%)
		WD40 repeat	561..599	CDD:293791	13/46 (28%)
		WD40 repeat	607..633	CDD:293791	5/25 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435283
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840