DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1571 and Dnai2

DIOPT Version :9

Sequence 1:	NP_572435.1	Gene:	CG1571 / 31725	FlyBaseID:	FBgn0029993	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_001030050.2	Gene:	Dnai2 / 432611	MGIID:	2685574	Length:	623	Species:	Mus musculus

Alignment Length:	646	Identity:	198/646 - (30%)
Similarity:	325/646 - (50%)	Gaps:	60/646 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FIYSRERRRFGRQCRFQDRN-ELMVSVHPSGRQRLKYIMANPSEKSTQLSRQMALTVMETENVTL 69
            ::|.::|..||:||.|.||. ||.:.:.|:......|:..||.:...|.|..|:.....||...:
Mouse     5 YVYLKKRSEFGKQCNFSDRQAELNIDILPNPELAALYVERNPVDTGIQCSASMSEHEANTERFEM 69

  Fly    70 DQHGMYHYEGGWPKEVNFNDEEQTQRHRKKVEREDSWGEQVLSMIRTTMSVAEQNNTLNIYQNFF 134
            :..|:.|.||||||:||..:.|||.|.|||||:::::...|:.:........:|||.::||:.:|
Mouse    70 ESCGVNHVEGGWPKDVNPQELEQTIRFRKKVEKDENYINAVMQLGSIMEHCIKQNNAIDIYEEYF 134

  Fly   135 ADLPPELGHDIKMRFRARVANVFHDLWLPARQLRSIEWMPNNSRQFMTQYTNHFAKGERLRPVTD 199
            .|  .|.....:....|:..|||.|.....|....:.|.|:.:|:....|:  ..|.:|
Mouse   135 DD--EEAVEVTEEAPSAKTINVFRDPQEIKRTATHLSWHPDGNRKLAVAYS--CLKFQR------ 189

  Fly   200 EPFGGTNGFYVWDVKNPLKPRITYDSKQQVSLAKICPKDENNMVGGTGLGQVCLWGTFKGGLPIR 264
            .|.......|:||::||.:|.|.......:...:..|||.:.::||...||:..|.|.||.|...
Mouse   190 APMSMNYDSYIWDLENPNRPEIALKPLSPLVTLEYNPKDSHVLLGGCYNGQIACWDTRKGSLVAE 254

  Fly   265 NCPLEVSHRETTSALCWVHSKSNTEFYSGSLDGSIKYWDTRDLKMPMQELLLEPEPQERQSRMDS 329
            ...:|.|||:......|:.||:.||.:|.|.||.:.:||.|.:..|::.::::...:|:..  ::
Mouse   255 LSTIEFSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKISEPIEVVIMDISRKEQLE--NA 317

  Fly   330 HGVTVLEFEYTIPVRFIIGSDMGHVFVGNRKGMTPMETLLAHYQLFVGPVRSINRNPFFVKNFLV 394
            .|...||||.|:|.:|::|::.|.|...|||..|..|.::..:....||:.::.||||:.||||.
Mouse   318 LGAISLEFESTLPTKFMVGTEQGIVISCNRKAKTQAEKIVCTFYGHHGPIYALQRNPFYPKNFLT 382

  Fly   395 TGDWRARIWSEEVKDSPSTMYFRKN-AQILCGAWSTGRCSLFVTGDINGVVDFWDLLLHHRKPIR 458
            .|||.||||||:.::| |.|:.:.: |.:..||||..|.::|.|..::|.:|.|||:.....|..
Mouse   383 VGDWTARIWSEDSRES-SIMWTKYHMAYLSDGAWSPVRPAVFFTTKMDGTLDIWDLVFKQCDPAL 446

  Fly   459 SVD------FKVAIADLVFRPEGDLLAIGLKNGDTHIMTLDESMRQATGKEKALMAAMFEREIVR 517
            |:.      |.:.:.|     .|.|:|.|.:.|.|.::.:..|:......||.:.:::||||..|
Mouse   447 SLKVCDDPLFCLRVQD-----NGCLIACGSELGTTTLLEVSSSLSTLQRNEKNIASSIFERETRR 506

  Fly   518 CKLLEARYDEVRLKRKTLQMAEEERVRKQQQLAPTLELDPDNPDQFVMMIEGDEEFRTAITEFQD 582
            .|:||||:.|:|||.|. ::..:|..:|:::.|  |:||.       ::.:.:|||      |:.
Mouse   507 EKILEARHREMRLKEKG-KVEGKEDDQKEEEAA--LDLDE-------LVGKAEEEF------FEV 555

  Fly   583 IILSVERKRSKRQVIMERTVFEEWNPADEKLQGEPVVYTKPERKVQTSGNYDKRTSGEPRA 643
            |...::||.:                  |.|:.:|....|...||:.....::....|..|
Mouse   556 IFSELKRKEA------------------EALKKKPKPRKKSSVKVEAEEEVEENVGEEEEA 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1571	NP_572435.1	WD40	210..462	CDD:295369	89/258 (34%)
		WD40	211..>488	CDD:225201	96/283 (34%)
		WD40 repeat	229..269	CDD:293791	12/39 (31%)
		WD40 repeat	277..325	CDD:293791	14/47 (30%)
		WD40 repeat	332..369	CDD:293791	15/36 (42%)
		WD40 repeat	379..415	CDD:293791	19/35 (54%)
		WD40 repeat	422..447	CDD:293791	9/24 (38%)
Dnai2	NP_001030050.2	WD40 repeat	165..212	CDD:293791	13/54 (24%)
		WD40	<166..495	CDD:225201	108/344 (31%)
		WD 1	214..254		12/39 (31%)
		WD40 repeat	220..259	CDD:293791	12/38 (32%)
		WD 2	261..302		16/40 (40%)
		WD40 repeat	266..361	CDD:293791	30/96 (31%)
		WD40 repeat	318..351	CDD:293791	14/32 (44%)
		WD 3	362..401		21/39 (54%)
		WD40 repeat	367..403	CDD:293791	20/36 (56%)
		WD 4	405..445		13/39 (33%)
		WD40 repeat	410..435	CDD:293791	9/24 (38%)
		WD 5	450..489		9/43 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..602		8/52 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4268
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2212
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.820