DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1571 and Dnai3

DIOPT Version :9

Sequence 1:	NP_572435.1	Gene:	CG1571 / 31725	FlyBaseID:	FBgn0029993	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_001128208.1	Gene:	Dnai3 / 292165	RGDID:	1563105	Length:	921	Species:	Rattus norvegicus

Alignment Length:	744	Identity:	149/744 - (20%)
Similarity:	256/744 - (34%)	Gaps:	231/744 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FIYSRERRRFGRQCRFQDRNELMVSVHPSGRQRLKYI-MANPSEKS---TQLSRQMALTVM---- 62
            ::.||:|.:||....|:|:|...|        :..|| ..:..:||   ||:.:.:.|.|:
  Rat   186 YMISRKRSQFGAPVTFRDQNASSV--------KDAYIECTSYPDKSYTLTQVEKDIGLQVIAEVK 242

  Fly    63 ETENVT---LDQHGMYHYEGGWPKEVNFNDEEQTQRHRKKVEREDSWGEQVLSMIRTTMSVA-EQ 123
            :|...|   ..::....|   :|:|  |::||      |.|..|.....:..|.:.|::.:| :|
  Rat   243 DTSTQTRWAFPRNATTQY---YPRE--FSEEE------KNVLVESKSLAEFFSTVSTSVEIALQQ 296

  Fly   124 NNTLNIYQNFFADLPPE---LGHDIKMRFRARVANVFHDLW-LPARQLRSIEWMPNNSRQFMTQY 184
            |..:|.:.:.:..|..|   .|.  |.....:....|.||. ...:.:..:.|.|......:...
  Rat   297 NEIMNTFTDDWRSLAEEESTFGD--KTDTHLKEYQSFTDLHNTMEKMITCVSWHPTIYGLIVVSV 359

  Fly   185 TNHFAKGER--------LRPVTDEPFGGTNGFYVWDVKNPLKPRITYDSKQQVSLAKICPKDENN 241
            ....:..||        |:|         :....|...:|:.|::..:|...:...:.||.|.|.
  Rat   360 AVRLSYEERVQNSSRLLLQP---------SLILFWSFSDPIHPQLMLESPDDIFCFEFCPSDPNI 415

  Fly   242 MVGGTGLGQVCLWG---------TFKGG-----------------------LPIRNC---PLEVS 271
            :.||...||:.||.         ..|.|                       :.:|:|   .:|..
  Rat   416 IAGGCINGQIILWDITAHAERIENIKTGGSRSKKATLKPMFLLEPDSNKEIMYVRHCAVSSIENG 480

  Fly   272 HRETTSALCWV---------------HSKSNTEFYSGSLDGSIKYWDTRDLK------------- 308
            ||:..:.:.|:               .|..|.:..:.|.|.:|.:||.|..|
  Rat   481 HRKVITDIHWLPDSFEINRMGSVFENRSGINCQLITCSADCTICFWDIRPQKPTVTSAATATTTS 545

  Fly   309 ----MPMQELLLEPEPQERQSRMD------------------------SHGVTVLEFEYTIPVRF 345
                .|.|    .|..::::..::                        |.|.|.|:.   .|.:.
  Rat   546 TTNTNPQQ----PPAEKKKEESIEIPFDVPSTFLHLDLSWKPLSRIKLSKGETSLDH---CPTKL 603

  Fly   346 IIGSDMG----------HV------------------------------------------FVGN 358
            .:|.|..          ||                                          |||.
  Rat   604 SLGEDPALCKIQGTSSIHVLLRDKMLSQMKLLKAAEINPYQNLEGGMANMLKPIEDFRTKFFVGT 668

  Fly   359 RKGMT-----PME------TLLAH-----YQLFVGPVRSINRNPFFVKNFLVTGDWRARIWSEEV 407
            .:|..     .||      .|:|.     |.:..|.|.::.|:|||....|..|.|...||.|||
  Rat   669 EEGEVIYTDWKMERDSETGRLMAKKPVNLYTVHDGAVHTVQRSPFFNDIILTVGGWNVAIWKEEV 733

  Fly   408 KDSPSTMYFRKNAQILCGAWSTGRCSLFVTGDINGVVDFWDLLLHHRKPIRSVDFKVAIADLV-- 470
            ...|.........:...|.||..|..:|..|..:|.||.||||....:|.:|....:.:...:
  Rat   734 LTGPLLQTCCAPKRYTAGHWSLTRPGVFYIGREDGYVDIWDLLEKTHEPAQSQSICITMITYIKP 798

  Fly   471 --FRPEGDLLAIGLKNGDTHIMTLDESMRQATGKEKALMAAMFEREIVRCKLLEARYDEVRLKRK 533
              |..:...:||....|..||:.:..::...:..|.:.:...||||:...:.::.| .|:|.:.|
  Rat   799 WTFSSKQQFIAIADYYGTLHILEIPWTLSHPSTNEVSSVNYYFEREVKHLEYVQQR-KEIREEEK 862

  Fly   534 ---TLQMAEEERV---RKQQQLAPTLELD 556
               .::|.:::..   |.::|:...|:|:
  Rat   863 KAMAMEMIKKKAKTYHRSKEQMEAELKLE 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1571	NP_572435.1	WD40	210..462	CDD:295369	82/410 (20%)
		WD40	211..>488	CDD:225201	86/439 (20%)
		WD40 repeat	229..269	CDD:293791	14/74 (19%)
		WD40 repeat	277..325	CDD:293791	13/79 (16%)
		WD40 repeat	332..369	CDD:293791	13/99 (13%)
		WD40 repeat	379..415	CDD:293791	14/35 (40%)
		WD40 repeat	422..447	CDD:293791	9/24 (38%)
Dnai3	NP_001128208.1	WD40	207..>532	CDD:225201	69/354 (19%)
Dnai3	NP_001128208.1	WD40	479..527	CDD:197651	8/47 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810