DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1571 and SdicA

DIOPT Version :9

Sequence 1:	NP_572435.1	Gene:	CG1571 / 31725	FlyBaseID:	FBgn0029993	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_001303576.1	Gene:	SdicA / 26067074	FlyBaseID:	FBgn0283432	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	449	Identity:	110/449 - (24%)
Similarity:	184/449 - (40%)	Gaps:	69/449 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 KEVNFNDEEQTQ------RHRKKVEREDSWGEQVLSMIRTTMSVAEQNNTLNIYQNFFADLPPEL 141
            ||||...|||.|      ..::.|.|.....|:.||            ..::||.::......|.
  Fly   117 KEVNELSEEQKQMIILSENFQRFVVRAGRVIERALS------------ENVDIYTDYIGGGDSEE 169

  Fly   142 GHDIKMRFRARVANVFHD-LWLPARQLRSIEWMPNNSRQFMTQYTNHFAKGERLRPVTDEPFGGT 205
            .:|.:...|..:..||:| .|...|.:.|::|..:.....:..|.|:       ....:||.|..
  Fly   170 ANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNN-------EESPNEPDGVV 227

  Fly   206 NGFYVWDVK-NPLKPRITYDSKQQVSLAKICPKDENNMVGGTGLGQVCLW-GTFKGGLPIRNCPL 268
               .||:.| ....|...:..:..|........:.|.::|||..||:.|| ...:...||:..||
  Fly   228 ---MVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPL 289

  Fly   269 E-VSHRETTSALCWVHSKSNTEFYSGSLDGSIKYWDTRDLKMPMQELLLEPEPQERQSRMDSHGV 332
            . .:|......|..|.:::.....|.|.||.:..|....|..|...|    |.|:|||:  :..:
  Fly   290 SAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTL----ELQQRQSK--AIAI 348

  Fly   333 TVLEFEYTIPVRFIIGSDMGHVFVGNRKGMTPMETLLAHYQLFVGPVRSINR-----NPFFVKNF 392
            |.:.|........::||:.|:|:..:|.|:  ...:...|:..:||:..|:.     :|.|...|
  Fly   349 TSMAFPANEINSLVMGSEDGYVYSASRHGL--RSGVNEVYERHLGPITGISTHYNQLSPDFGHLF 411

  Fly   393 LVTG-DWRARIWSEEVKDSPSTMYFRKNAQ-ILCGAWSTGRCSLFVTGDINGVVDFWDLLLHHRK 455
            |.:. ||..::||  :||:.....|..|:. ::..|||....:||...|.:|.:|.|:|
  Fly   412 LTSSIDWTIKLWS--LKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNL------ 468

  Fly   456 PIRSVDFKVAIADLV-----------FRPEGDLLAIGLKNGDTHIMTLDESMRQATGKE 503
               :.|.:|.||.:|           :.|.|..:.||.:.|..::..:.|::.|.:..|
  Fly   469 ---NQDTEVPIASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1571	NP_572435.1	WD40	210..462	CDD:295369	67/261 (26%)
		WD40	211..>488	CDD:225201	76/297 (26%)
		WD40 repeat	229..269	CDD:293791	12/40 (30%)
		WD40 repeat	277..325	CDD:293791	13/47 (28%)
		WD40 repeat	332..369	CDD:293791	8/36 (22%)
		WD40 repeat	379..415	CDD:293791	11/41 (27%)
		WD40 repeat	422..447	CDD:293791	8/24 (33%)
SdicA	NP_001303576.1	Dynein_IC2	23..51	CDD:288403
		NtpH	108..>178	CDD:225368	17/72 (24%)
		WD40	196..512	CDD:295369	84/344 (24%)
		WD40 repeat	196..245	CDD:293791	11/58 (19%)
		WD40	<224..523	CDD:225201	80/320 (25%)
		WD40 repeat	251..289	CDD:293791	10/37 (27%)
		WD40 repeat	298..337	CDD:293791	10/42 (24%)
		WD40 repeat	349..435	CDD:293791	22/89 (25%)
		WD40 repeat	441..479	CDD:293791	14/46 (30%)
		WD40 repeat	487..513	CDD:293791	5/25 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435278
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940