DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1571 and DYNC1I1

DIOPT Version :9

Sequence 1:NP_572435.1 Gene:CG1571 / 31725 FlyBaseID:FBgn0029993 Length:651 Species:Drosophila melanogaster
Sequence 2:NP_004402.1 Gene:DYNC1I1 / 1780 HGNCID:2963 Length:645 Species:Homo sapiens


Alignment Length:504 Identity:112/504 - (22%)
Similarity:186/504 - (36%) Gaps:57/504 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 RFQDRNELMVSVHPSGRQRLKYIMANPSE-KSTQLSRQMALTVMETENVTLDQHGMYHYEGGWPK 83
            :.|..:||...:|..|..::..:...|.| .|.....|..|...::|....|:. |...:.|...
Human   134 QLQSDSELGRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLATHQSEEDEEDEE-MVESKVGQDS 197

  Fly    84 EVNFNDEEQTQRH---RKKVEREDS---WGEQVLSMIRTTMSVAEQ--NNTLNIYQNFFADLPPE 140
            |:...|::|..:.   |:..|.|..   ..|:.|.....|:.|.|:  ....:|:.::......|
Human   198 ELENQDKKQEVKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRELEE 262

  Fly   141 LGHDIKMRFRARVANVFHD-LWLPARQLRSIEWMPNNSRQFMTQYTNHFAKGERLRPVTDEPFGG 204
            ...|::..........|:| .|...|.:..::|........:..|.|:          .|.|...
Human   263 KDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYNNN----------EDAPHEP 317

  Fly   205 TNGFYVWDVK-NPLKPRITY---DSKQQVSLAKICPKDENNMVGGTGLGQVCLW-GTFKGGLPIR 264
            .....||::| ....|...:   .|...|..|:..|   |.:||||..||:.|| .......|::
Human   318 DGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHP---NLVVGGTYSGQIVLWDNRSHRRTPVQ 379

  Fly   265 NCPLE-VSHRETTSALCWVHSKSNTEFYSGSLDGSIKYWDTRDLKMPMQELLLEPEPQERQSRMD 328
            ..||. .:|......:..|.:::.....:.|.||.:..|....|..|.:.:.|.      .::..
Human   380 RTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELV------YNKSK 438

  Fly   329 SHGVTVLEFEYTIPVRFIIGSDMGHVFV----GNRKGMTPMETLLAHYQLFVGPVRSINRN---- 385
            ...||.:.|.......|::||:.|.|:.    |::.|:.  |....|.    |||..||.:    
Human   439 PVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIG--EVFEGHQ----GPVTGINCHMAVG 497

  Fly   386 PFFVKNFLVTG--DWRARIWSEEVKDSPSTMYFRKNAQILCGA-WSTGRCSLFVTGDINGVVDFW 447
            |....:..||.  ||..::|:  .|.:.....|..||..:... ||....:||...|..|.:|.|
Human   498 PIDFSHLFVTSSFDWTVKLWT--TKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLW 560

  Fly   448 DLLLHHRKPIRSVDFKVAIA--DLVFRPEGDLLAIGLKNGDTHIMTLDE 494
            :|......|..||..:.|.|  .:.:...|..:|:|...|...:..:.|
Human   561 NLNNDTEVPTASVAIEGASALNRVRWAQAGKEVAVGDSEGRIWVYDVGE 609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1571NP_572435.1 WD40 210..462 CDD:295369 68/268 (25%)
WD40 211..>488 CDD:225201 73/295 (25%)
WD40 repeat 229..269 CDD:293791 14/40 (35%)
WD40 repeat 277..325 CDD:293791 8/47 (17%)
WD40 repeat 332..369 CDD:293791 11/40 (28%)
WD40 repeat 379..415 CDD:293791 10/41 (24%)
WD40 repeat 422..447 CDD:293791 7/25 (28%)
DYNC1I1NP_004402.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58
Interaction with DCTN1. /evidence=ECO:0000250 2..123
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..125
Dynein_IC2 147..173 CDD:371592 5/25 (20%)
Interaction with DYNLT1. /evidence=ECO:0000269|PubMed:27502274 147..163 2/15 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..221 11/52 (21%)
WD40 283..606 CDD:392136 81/349 (23%)
WD 1 285..334 9/58 (16%)
WD40 repeat 291..337 CDD:293791 9/55 (16%)
WD 2 338..378 13/42 (31%)
WD40 repeat 346..385 CDD:293791 15/41 (37%)
WD 3 387..428 8/40 (20%)
WD40 repeat 393..434 CDD:293791 8/46 (17%)
WD 4 437..477 10/39 (26%)
WD40 repeat 442..481 CDD:293791 11/40 (28%)
WD 5 482..527 13/50 (26%)
WD40 repeat 488..529 CDD:293791 9/42 (21%)
WD 6 530..570 11/39 (28%)
WD40 repeat 535..573 CDD:293791 10/37 (27%)
WD 7 576..615 7/34 (21%)
WD40 repeat 581..607 CDD:293791 4/25 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1587
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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