DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1571 and dnai2

DIOPT Version :9

Sequence 1:	NP_572435.1	Gene:	CG1571 / 31725	FlyBaseID:	FBgn0029993	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	XP_031750209.1	Gene:	dnai2 / 100495747	XenbaseID:	XB-GENE-854694	Length:	593	Species:	Xenopus tropicalis

Alignment Length:	633	Identity:	215/633 - (33%)
Similarity:	325/633 - (51%)	Gaps:	61/633 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FIYSRERRRFGRQCRFQDR-NELMVSVHPSGRQRLKYIMANPSEKSTQLSRQMALTVMETENVTL 69
            ::|:|:|..|||||.|.|| .||.|.:.|...|.|.:|..||.:.:.|.|.:|:...:.||...:
Frog    11 YVYTRKRSEFGRQCNFSDRPAELHVDILPDPSQALNFIERNPCDVAIQCSHEMSEHEVNTERYEM 75

  Fly    70 DQHGMYHYEGGWPKEVNFNDEEQTQRHRKKVEREDSWGEQVLSMIRTTMSVAE----QNNTLNIY 130
            :..|:.|.||||||::|..:.|||.|.|||||::|.:    ::.|....||.|    |||.:|||
Frog    76 EARGINHVEGGWPKDINPQEMEQTIRFRKKVEKDDHY----IATISQLGSVMEHCIKQNNAINIY 136

  Fly   131 QNFFADLPPELGHDIKMRFRARVANVFHDLWLPARQLRSIEWMPNNSRQFMTQYT-NHFAKGERL 194
            :.:|.|.....|.|...  .|...|||.|.....|....:.|.|:.||:....|: ..|.:..:
Frog   137 EEYFEDTEELEGMDETP--SANTVNVFRDPNEIKRTATHLSWHPDGSRKLAVAYSCLDFQRAPK- 198

  Fly   195 RPVTDEPFGGTNGFYVWDVKNPLKPRITYDSKQQVSLAKICPKDENNMVGGTGLGQVCLWGTFKG 259
                |..:..    |:||::.|.||.:|......:...:..|||.:.:|||...||:..|.|.||
Frog   199 ----DMSYES----YIWDIEIPNKPELTLKPVSPLVCLEYNPKDSHVLVGGCYNGQIAYWDTRKG 255

  Fly   260 GLPIRNCPLEVSHRETTSALCWVHSKSNTEFYSGSLDGSIKYWDTRDLKMPMQELLLEPEPQERQ 324
            |.|:.:..:|.|||:....:.|:.||:.||.:|.|.||.|.:||.|.|..|.::|:|:...:|..
Frog   256 GNPMESTVIEHSHRDPVYKVIWLQSKTGTECFSASTDGQILWWDIRKLSEPTEKLILDISKKENL 320

  Fly   325 SRMDSHGVTVLEFEYTIPVRFIIGSDMGHVFVGNRKGMTPMETLLAHYQLFVGPVRSINRNPFFV 389
            .  ::.|...||||.|:|.:|::|::.|.:...|||..||.|.::..|....||:.||.||||:.
Frog   321 D--NALGAVSLEFEPTLPTKFMVGTEQGMIVSCNRKAKTPPEKIVCTYGGHHGPIYSIQRNPFYP 383

  Fly   390 KNFLVTGDWRARIWSEEVKDSPSTMYFRKNAQILCGA-WSTGRCSLFVTGDINGVVDFWDLLLHH 453
            ||||..|||.||||||:.::| |.|:.:.:...|..| ||..|.::|:|..::|.:|.||.:...
Frog   384 KNFLTVGDWTARIWSEDCRES-SIMWTKYHMSYLTDACWSPTRPTVFLTTKMDGTLDVWDYMYKQ 447

  Fly   454 RKPIRSVDFKVA---IADLVFRPEGDLLAIGLKNGDTHIMTLDESMRQATGKEKALMAAMFEREI 515
            ..|  |:..||:   :..:..:..|..:|.|.:.|.|.:|.|.:.:......|:.|.:||||||.
Frog   448 NNP--SLSVKVSGEPLYSIRMQDNGRFVACGSQMGVTTLMELSKGLYTLQRNERNLASAMFERET 510

  Fly   516 VRCKLLEARYDEVRLKRKTLQMAEEERVRKQQQLAPTLELDPDNPDQFVMMIEGDEEFRTAITEF 580
            .|.|:||||:.|:|||.::             :..|..|:..:.|.:     :.:|....|..:|
Frog   511 KREKILEARHREMRLKERS-------------KAEPGEEVKEEKPAE-----DMNEIIANAEKDF 557

  Fly   581 QDIILSVERKRSKRQVIMERTVFEEWNPADEKLQGEPVVYTKPERKVQ 628
            .:|| ..|.||.::|        |...|.||..:.|    ...|:.||
Frog   558 FEII-EAELKRKEQQ--------ERKQPEDEHQEKE----VSEEKIVQ 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1571	NP_572435.1	WD40	210..462	CDD:295369	96/252 (38%)
		WD40	211..>488	CDD:225201	102/280 (36%)
		WD40 repeat	229..269	CDD:293791	14/39 (36%)
		WD40 repeat	277..325	CDD:293791	18/47 (38%)
		WD40 repeat	332..369	CDD:293791	15/36 (42%)
		WD40 repeat	379..415	CDD:293791	21/35 (60%)
		WD40 repeat	422..447	CDD:293791	9/25 (36%)
dnai2	XP_031750209.1	WD40 repeat	105..141	CDD:293791	14/39 (36%)
		WD40	<172..495	CDD:225201	113/336 (34%)
		WD40 repeat	172..221	CDD:293791	14/57 (25%)
		WD40 repeat	226..265	CDD:293791	14/38 (37%)
		WD40 repeat	273..314	CDD:293791	17/40 (43%)
		WD40 repeat	326..367	CDD:293791	15/40 (38%)
		WD40 repeat	373..409	CDD:293791	22/36 (61%)
		WD40 repeat	416..441	CDD:293791	9/24 (38%)
		tolA_full	<509..>593	CDD:274303	31/115 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217312at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12442
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2212
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110