DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf2 and AT2G39260

DIOPT Version :9

Sequence 1:	NP_572434.1	Gene:	Upf2 / 31724	FlyBaseID:	FBgn0029992	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_181459.4	Gene:	AT2G39260 / 818511	AraportID:	AT2G39260	Length:	1181	Species:	Arabidopsis thaliana

Alignment Length:	1267	Identity:	366/1267 - (28%)
Similarity:	597/1267 - (47%)	Gaps:	198/1267 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 EAEEREELQQFISELREKIESKRQLRLQNSTIELPGEEYFAKLDSNLKKNTAFVKKLKLFTATQL 122
            |.::.||....:.|:::.||:|..||..|...|.|...|...|||::|:|||.:||||.....|.
plant    11 EKQDDEEALARLEEIKKSIEAKLTLRQNNLNPERPDSAYLRTLDSSIKRNTAVIKKLKQINEEQR 75

  Fly   123 DGLLREISALNLSKYISEICAALVEAKLKMTDVPAVVTLASRLHCTYADFDVHFLEAWQK----- 182
            :||:.::..:||||::||...|:.|||||.:|:.|.|.:.|.||..|.:|.....:...|
plant    76 EGLMDDLRGVNLSKFVSEAVTAICEAKLKSSDIQAAVQICSLLHQRYKEFSASLTQGLLKVFFPG 140

  Fly   183 --ALNIKATEKIGNPSKLRVDLRLFAELVSSGVIQMKPGLAQLGVVLVHLI--------ALDKD- 236
              |.:::| :|.....|.|..|:|..||...|||:...       :.:::|        ..|:|
plant   141 KSAEDLEA-DKNSKAMKKRSTLKLLLELYYVGVIEDSN-------IFINIIKDLTSVEQLKDRDT 197

  Fly   237 DHSNFSIILSFCRHCGEEYAGLVPQKMQQLATKYGVEVPKSDFLTADKQLNLRTMLKGYFKALCK 301
            ..:|.:::.||.|. |..:.|| |...|......|::|      |||::.:.:.....|:.||..
plant   198 TQTNLTLLTSFARQ-GRIFLGL-PISGQDEDFFKGLDV------TADQKKSFKKAFNTYYDALAD 254

  Fly   302 HVLAEQAELMNMTKNIRRTMECKGEISTEKREKCELMQAGFDKLLASAQSLSELLG-EP--LPE- 362
            .:.:|...|:.|.|...:.:..|||:|.:.....|.::..:|.|..:..||:|.|. :|  :||
plant   255 LLQSEHKLLLQMEKENAKLVNAKGELSEDSASSYEKLRKSYDHLYRNISSLAEALDMQPPVMPED 319

  Fly   363 ----LAKESEGCNPGTVIDNMLDSASFGVLDP-WGDEETRAFYTDLPDLRQFLP----NFSAPKV 418
                |....|....|||.|.       .|.:| |.||:|:.||..|||||.|:|    ..:.||.
plant   320 GTTRLTAGDEASPSGTVKDT-------SVPEPIWDDEDTKTFYECLPDLRAFVPAVLLGEAEPKS 377

  Fly   419 DLETLEEPSELTEEAIDANLDAEMDLDDPPSTTSDTT---------PENPIEEQPTTPVAAAEDL 474
            :.::.:...:|:|        :..::.:...||.|||         .:....|||    ...|::
plant   378 NEQSAKAKEKLSE--------SSSEVVENQQTTEDTTEVSADSASMDDRSNAEQP----KEKEEV 430

  Fly   475 KPQKMGNALMELGRQQQQQSQLNQNPIQIQNQMRQQFDGFLVNLFNCVNKELIDSAAIEFLLNFN 539
            :.:|..:...|.|:::..:.::.....:.::.....|:..|..|..||:::|||...:|:.. .|
plant   431 EKEKAKDTKKEKGKEKDSEKKMEHEKEKGKSLDVANFERLLQRLPGCVSRDLIDQLTVEYCY-LN 494

  Fly   540 TKHQRKKLTRTIFSVQRTRLDILPYLSRFVAIVHMCNTDVATDLAELLRKEFKWHIHKKNQLNIE 604
            :|..||||.:.:|:|.||.|::|.|.||.||.:..|..|:.:.|.::|..||...:|||:|:|||
plant   495 SKTNRKKLVKALFNVPRTSLELLAYYSRMVATLASCMKDIPSMLVQMLEDEFNSLVHKKDQMNIE 559

  Fly   605 TKLKIVRFIGELVKFGLFKKFDALGCLKMLLRDFQHHQIEMACAFVEVTGVYLYNCRDARLLMNV 669
            ||::.:||||||.||.:........|||..|.:|.||.|::||..:|..|.:||...:..|.|..
plant   560 TKIRNIRFIGELCKFKIVPAGLVFSCLKACLDEFTHHNIDVACNLLETCGRFLYRSPETTLRMTN 624

  Fly   670 FLDQMLRLKTATAMDSRHAAQIESVYYLVKPPESSKREPMVRPAMHEYIRYLIFEELCKQNVDRC 734
            .||.::|||....:|.|.:..:|:.|||.||||.|.|...|||.:|:|:|.|:|.:|.|.::...
plant   625 MLDILMRLKNVKNLDPRQSTLVENAYYLCKPPERSARISKVRPPLHQYVRKLLFSDLDKDSIANV 689

  Fly   735 IKMLRRIDWQDPETNCYAIKCLSKAYLLRFQLIRCLADLVSGLSSYQPRAVTIVIDNVFEDIRAG 799
            :|.||::.|.:.|.  |.:||..|.:..::..|..:|.|.||||.:....|..|:|.|.|:||.|
plant   690 LKQLRKLPWSECEQ--YILKCFMKVHKGKYGQIHLIASLTSGLSRHHDEFVVAVVDEVLEEIRVG 752

  Fly   800 LEIHSPRMAQRRIAMAKYLGEMYNYKLVESTNILNTLYSIISLGVSNDQNVVSPLDPPDSLFRLK 864
            ||::.....|:|:|..::|||:|||:.|:|:.|..|||  ::|...:|.:....||||:..||::
plant   753 LELNEYGAQQKRLAHMRFLGELYNYEHVDSSVIFETLY--LTLLYGHDTSEQEVLDPPEDFFRVR 815

  Fly   865 LACMLLDTCAPYFTSQATRKKLDYFLVFFQHYYWFKKSHPVFSKTENTSDLFPILMDHTYRDCLL 929
            :..:||:||..||...:::|:||.||:.||.|. ..|.|            .|:.::...:|...
plant   816 MVIILLETCGHYFDRGSSKKRLDQFLIHFQRYI-LSKGH------------LPLDIEFDLQDLFA 867

  Fly   930 NVRPKLKIYKSLEQAKAAIDHLQEK------------LYPQLKTTNNAQDPSLGT--ISEISEID 980
            |:||.:..|.::::..|||..|:|:            .:...|.:|.:....:.:  .|...:|.
plant   868 NLRPNMTRYSTIDEVNAAILQLEEREHASSGDKVSIERHSDTKPSNKSSSDVISSNGKSTAKDIR 932

  Fly   981 EGG------TDEDSGSSNDQRERQ---------VSGQEQDQSNDWTENEAEPPLPPLPPPEKSK- 1029
            |.|      :|.||||.:..|:.|         ..|.|....:|:.:.:.       |..:..|
plant   933 ENGEAHGEESDSDSGSGSVVRDGQNEELDDGNHERGSESGDGDDYDDGDG-------PGSDDDKF 990

  Fly  1030 ------------EDLEFEQLYEKMTTDSYQERLKEPIKATAKDIPVPMMARLQKKSYDQITGAQT 1082
                        |..:|:|..:.:..:|.::|..|.....|.::.:||.. .:....|.....:.
plant   991 RVRQKVVTVDLEEQADFDQELKALLQESMEQRKLELRGRPALNMTIPMSV-FEGSGKDHHHFGRV 1054

  Fly  1083 IGPGINNMSQISKSVPNQDGTPGSPGADSPDGNGKSGGGVGGSDVGAAGAAGASGATSVPFVLMV 1147
            :|..                  |....|..:|..:                      .|...::|
plant  1055 VGEN------------------GEEVLDEENGEQR----------------------EVQVKVLV 1079

  Fly  1148 RGHKGGKQQFKSFVAPSDSHLATNLKRQEQMIREEKEKVKRLTLNITERIEEEDYQESLMPPQHR 1212
            :  :|.|||.:..:.|||..|..:.|::|....|||:.:|||.|...||.|||   .:.:..|..
plant  1080 K--RGNKQQTRQMLIPSDCALVQSTKQKEAAELEEKQDIKRLVLEYNERDEEE---ANGLGTQIL 1139

  Fly  1213 NFTQ------------SYYQKPNKHKFKHQKG 1232
            |:|.            |.....::|:|.:.:|
plant  1140 NWTSGGSRGSTRTGEGSGKSGGSRHRFYYHQG 1171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf2	NP_572434.1	MIF4G	104..300	CDD:214713	63/211 (30%)
		MIF4G	518..701	CDD:214713	75/182 (41%)
		MIF4G	716..934	CDD:280935	75/217 (35%)
		Upf2	980..1192	CDD:281974	46/239 (19%)
AT2G39260	NP_181459.4	MIF4G	57..>196	CDD:413423	46/146 (32%)
		MIF4G	468..656	CDD:214713	76/188 (40%)
		MIF4G	671..872	CDD:214713	75/217 (35%)
		Upf2	992..1122	CDD:397938	32/172 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	151	1.000	Domainoid score	I1407
eggNOG	1	0.900	-	-		E1_KOG2051
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6101
Inparanoid	1	1.050	487	1.000	Inparanoid score	I331
OMA	1	1.010	-	-		QHG55567
OrthoDB	1	1.010	-	-		D653534at2759
OrthoFinder	1	1.000	-	-		FOG0005166
OrthoInspector	1	1.000	-	-		oto2996
orthoMCL	1	0.900	-	-		OOG6_103377
Panther	1	1.100	-	-	LDO	PTHR12839
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3685
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840