DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Upf2 and upf2

DIOPT Version :9

Sequence 1:	NP_572434.1	Gene:	Upf2 / 31724	FlyBaseID:	FBgn0029992	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	XP_017210611.1	Gene:	upf2 / 569006	ZFINID:	ZDB-GENE-090715-1	Length:	583	Species:	Danio rerio

Alignment Length:	580	Identity:	214/580 - (36%)
Similarity:	313/580 - (53%)	Gaps:	93/580 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   543 QRKKLTRTIFSVQRTRLDILPYLSRFVAIVHMCNTDVATDLAELLRKEFKWHIHKKNQLNIETKL 607
            |.....|.:|:|.|.|||:||:.:|.||.:|.|.:|||.||..:|:.:|::||.||:|:|||||.
Zfish    19 QETLAVRALFTVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLKGDFRFHIRKKDQINIETKN 83

  Fly   608 KIVRFIGELVKFGLFKKFDALGCLKMLLRDFQHHQIEMACAFVEVTGVYLYNCRDARLLMNVFLD 672
            |.|||||||.||.:|.|.|.|.|||::|.||.||.|||||..:|..|.:|:...|:.|..:|.|:
Zfish    84 KTVRFIGELAKFKMFSKTDTLHCLKVMLSDFSHHHIEMACTLLETCGRFLFRSPDSHLRTSVLLE 148

  Fly   673 QMLRLKTATAMDSRHAAQIESVYYLVKPPESSKREPMVRPAMHEYIRYLIFEELCKQNVDRCIKM 737
            ||:|.|.|..:|.|:...:|:.||...||...|.....||.:.||||.|::::|.|...::.::.
Zfish   149 QMMRKKQAQHLDVRYVTMVENAYYYCNPPPMEKTVRRKRPPLQEYIRKLLYKDLSKVTTEKVLRQ 213

  Fly   738 LRRIDWQDPETNCYAIKCLSKAYLLRFQLIRCLADLVSGLSSYQPRAVTIVIDNVFEDIRAGLEI 802
            :|::.|.|.|...|.|.|:...:.:::..| |:|:|::||.:||......|:|.|.||||.|:|:
Zfish   214 MRKLPWHDSEVKGYLICCMVNIWNVKYNSIXCVANLLAGLVAYQEDVGIHVVDGVLEDIRLGMEV 278

  Fly   803 HSPRMAQRRIAMAKYLGEMYNYKLVESTNILNTLYSIISLGVSNDQNVVSPLDPPDSLFRLKLAC 867
            :.|:..||||:.||:|||:|||::|||..|..||:|.||.||:.| ...||||||:.|||:::.|
Zfish   279 NQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLFSFISFGVNTD-GTASPLDPPEHLFRIRMVC 342

  Fly   868 MLLDTCAPYFTSQATRKKLDYFLVFFQHYYWFKKSHPVFSKTENTSDLFPILMDHTYRDCLLNVR 932
            .|||||..||...:::||||.||::||.|.|:|||..|::|.:.    |||.:::...|.|..:|
Zfish   343 TLLDTCGQYFDRGSSKKKLDCFLIYFQRYIWWKKSLDVWTKDQP----FPIDIEYMITDTLEMLR 403

  Fly   933 PKLKI---------------YKSLEQAKAAIDHLQEKLYPQLKTTNNAQDPSLGTISEISE---- 978
            ||:|:               ..||...|..::            .:.....|||....:.|
Zfish   404 PKMKLCSLWRRPALTSACWRESSLSNWKRGLE------------KDGRSSSSLGESEALDEEDDD 456

  Fly   979 -IDEGG--TDEDS------------------GSSNDQRERQVSGQEQDQSNDW-----TENE--- 1014
             .||||  |:|.|                  ||.|::.||    :|::::.|:     .|||
Zfish   457 DEDEGGAETEEQSGNESEMNEPEEEVNIITEGSENEEEER----EEEEENTDYLTDSNKENETDE 517

  Fly  1015 -----------------AEPPLPPLP-----PPEKSKEDLEFEQ--LYEKMTTDSYQERL 1050
                             |.|||..||     .|..|.......|  |:....:.|:.::|
Zfish   518 ENNLPFIFISSPSSSSSAAPPLHQLPLHLISIPSSSSAAPPLHQLPLFISSPSSSFHQQL 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf2	NP_572434.1	MIF4G	104..300	CDD:214713
		MIF4G	518..701	CDD:214713	76/157 (48%)
		MIF4G	716..934	CDD:280935	94/217 (43%)
		Upf2	980..1192	CDD:281974	29/123 (24%)
upf2	XP_017210611.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I3664
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6101
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D653534at2759
OrthoFinder	1	1.000	-	-		FOG0005166
OrthoInspector	1	1.000	-	-		oto39739
orthoMCL	1	0.900	-	-		OOG6_103377
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3685
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.820