DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Upf2 and UPF2

DIOPT Version :10

Sequence 1:NP_572434.1 Gene:Upf2 / 31724 FlyBaseID:FBgn0029992 Length:1241 Species:Drosophila melanogaster
Sequence 2:NP_056357.1 Gene:UPF2 / 26019 HGNCID:17854 Length:1272 Species:Homo sapiens


Alignment Length:1327 Identity:476/1327 - (35%)
Similarity:707/1327 - (53%) Gaps:199/1327 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 TTDSEVSTPPSSRKDLADGVAEGDNDNDIDTGDTD------------------------------ 42
            |...|||..|..:|...:.......|.:....|.:                              
Human    44 TAKKEVSKAPEDKKKRLEDDKRKKEDKERKKKDEEKVKAEEESKKKEEEEKKKHQEEERKKQEEQ 108

  Fly    43 ANADEDVDAAAAIALEAEEREELQQFISELREKIESKRQLRL--QNSTIELPGEEYFAKLDSNLK 105
            |...::.:|||    :.:|:||..|...|..|:...:::||.  ||:....|.|.:|::|||:||
Human   109 AKRQQEEEAAA----QMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFSRLDSSLK 169

  Fly   106 KNTAFVKKLKLFTATQLDGLLREISALNLSKYISEICAALVEAKLKMTDVPAVVTLASRLHCTYA 170
            ||||||||||..|..|.|.|..:.:.|||||||:|..|::||||||::||...|.|.|..|..||
Human   170 KNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKISDVNCAVHLCSLFHQRYA 234

  Fly   171 DFDVHFLEAWQKALNIKATEKIGNPSKLRVDLRLFAELVSSGVIQMKPGLAQLGVVLVHLIALDK 235
            ||....|:.|:|....:..||..|.:|||.|||..|||...|:...|.||:.:...|.::|..|:
Human   235 DFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKNIINADR 299

  Fly   236 DDHSNFSIILSFCRHCGEEYAGLVPQKMQQLATKYGVEVPKSDFLTADKQLNLRTMLKGYFKALC 300
            :.|::.|:::|||||||::.|||||:|::..|.|:.:..|.|:.::.:||...:.:||.||.:|.
Human   300 ESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSLT 364

  Fly   301 KHVLAEQAELMNMTKNIRRTMECKGEISTEKREKCELMQAGFDKLLASAQSLSELLGEPLPELAK 365
            ||:..:..||.|..:..||.:..|||:|.::.::.|.....:.||||::|||::||.|.:|:|.:
Human   365 KHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQ 429

  Fly   366 ES---EGCNPGTVIDNMLDSASFGVLD----PWGDEETRAFYTDLPDLRQFLP------------ 411
            :.   |...||  || :......|..|    .|.||:.|.||.:|.||:.|:|            
Human   430 DKPTPEEHGPG--ID-IFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSCQ 491

  Fly   412 NFSAPKVDLETLEEPSELTEEAIDANLDAEMDLDDPPSTTSDTTPENPIEEQPTTPVAAAEDLKP 476
            |..:.|.|.:..:|..|..|  :.:..|.|::|::  ...:|.|.|....::       |||| .
Human   492 NKESNKDDTKEAKESKENKE--VSSPDDLELELEN--LEINDDTLELEGGDE-------AEDL-T 544

  Fly   477 QKMGNALMELGRQQQQQSQLNQNPIQIQNQMRQQFDGFLVNLFNCVNKELIDSAAIEFLLNFNTK 541
            :|:      |..|:|:..:.:..     :.::...|.||..|.||||::|||.||::|.:|.|||
Human   545 KKL------LDEQEQEDEEASTG-----SHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTK 598

  Fly   542 HQRKKLTRTIFSVQRTRLDILPYLSRFVAIVHMCNTDVATDLAELLRKEFKWHIHKKNQLNIETK 606
            ..||||.|.:|.|.|.|||:||:.:|.||.:|.|.:|||.||..:||.:|::|:.||:|:|||||
Human   599 ANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETK 663

  Fly   607 LKIVRFIGELVKFGLFKKFDALGCLKMLLRDFQHHQIEMACAFVEVTGVYLYNCRDARLLMNVFL 671
            .|.|||||||.||.:|.|.|.|.||||||.||.||.|||||..:|..|.:|:...::.|..:|.|
Human   664 NKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLL 728

  Fly   672 DQMLRLKTATAMDSRHAAQIESVYYLVKPPESSKREPMVRPAMHEYIRYLIFEELCKQNVDRCIK 736
            :||:|.|.|..:|:|:...:|:.||...||.:.|.....||.:.||:|.|::::|.|...::.::
Human   729 EQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVKKKRPPLQEYVRKLLYKDLSKVTTEKVLR 793

  Fly   737 MLRRIDWQDPETNCYAIKCLSKAYLLRFQLIRCLADLVSGLSSYQPRAVTIVIDNVFEDIRAGLE 801
            .:|::.|||.|...|.|.|:...:.:::..|.|:|:|::||..||......|:|.|.||||.|:|
Human   794 QMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGME 858

  Fly   802 IHSPRMAQRRIAMAKYLGEMYNYKLVESTNILNTLYSIISLGVSNDQNVVSPLDPPDSLFRLKLA 866
            ::.|:..||||:.||:|||:|||::|||..|..||||..|.||:.|.: .|.||||:.|||::|.
Human   859 VNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGS-PSSLDPPEHLFRIRLV 922

  Fly   867 CMLLDTCAPYFTSQATRKKLDYFLVFFQHYYWFKKSHPVFSKTENTSDLFPILMDHTYRDCLLNV 931
            |.:||||..||...::::|||.|||:||.|.|:|||..|::|...    |||.:|:...|.|..:
Human   923 CTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHP----FPIDIDYMISDTLELL 983

  Fly   932 RPKLKIYKSLEQAKAAIDHLQEKLYPQLKTTNNAQDPSLGT----ISEISEIDEGGT-------- 984
            |||:|:..|||::...:..|:.:...:|...|:.......|    :.|..|.:|||.        
Human   984 RPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKDSKDSMTEGENLEEDEEEEEGGAETEEQSGN 1048

  Fly   985 -------DEDSGSSNDQRERQVSGQEQDQSN-DW-----TENEAEPP----------LPPLPPPE 1026
                   :|:.||.||..|    |:|:::.| |:     .|||.:..          |..:|   
Human  1049 ESEVNEPEEEEGSDNDDDE----GEEEEEENTDYLTDSNKENETDEENTEVMIKGGGLKHVP--- 1106

  Fly  1027 KSKEDLEFEQLYEKMTTDSYQERLKEPIKATAKDIPVPMMARLQKKSYDQITGAQTIGPGINNMS 1091
             ..||.:|.|..:||..::.|:|..|.:|....|:.:|:..:                      |
Human  1107 -CVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLK----------------------S 1148

  Fly  1092 QISKSVPNQDGTPGSPGADSPDGNGKSGGGVGGSDVGAAGAAGASGATSVPFVLMVRGHKGGKQQ 1156
            |:.|..|                   .|||.|          .|..|.::|||::.|  ||.|||
Human  1149 QLRKGPP-------------------LGGGEG----------EAESADTMPFVMLTR--KGNKQQ 1182

  Fly  1157 FKSFVAPSDSHLATNLKRQEQMIREEKEKVKRLTLNITERIEEEDYQESLMPPQHRNFTQSYYQK 1221
            ||....|..|.||.|...|:|..:||:.::|:|||:|.||.|:|||||.|         ||..|:
Human  1183 FKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEML---------QSLAQR 1238

  Fly  1222 P--------NKHKFKHQKGAPDADLIF 1240
            |        .:.:::|.||||:|||||
Human  1239 PAPANTNRERRPRYQHPKGAPNADLIF 1265

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Upf2NP_572434.1 MIF4G 104..300 CDD:397130 88/195 (45%)
MIF4G 518..701 CDD:214713 95/182 (52%)
MIF4G 716..934 CDD:397130 94/217 (43%)
Upf2 1029..1192 CDD:461146 45/162 (28%)
UPF2NP_056357.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..126 13/85 (15%)
Sufficient for interaction with UPF1 94..133 8/42 (19%)
MIF4G 168..363 CDD:214713 88/194 (45%)
DUF1451 358..>421 CDD:450347 23/62 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 370..389 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 423..445 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 490..517 6/28 (21%)
MIF4G 571..758 CDD:214713 97/186 (52%)
Sufficient for interaction with UPF3A and UPF3B 711..928 87/217 (40%)
Sufficient for interaction with EIF4A1 and EIF1. /evidence=ECO:0000269|PubMed:11073994 757..1272 199/584 (34%)
MIF4G 776..986 CDD:397130 92/214 (43%)
Binds to UPF3B 839..859 8/19 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1018..1098 19/83 (23%)
Sufficient for interaction with UPF1 C-terminus 1084..1272 75/248 (30%)
Upf2 1095..1218 CDD:461146 47/179 (26%)
Necessary for interaction with UPF1 1105..1198 38/149 (26%)
Interaction with UPF1 1105..1129 8/27 (30%)
Interaction with UPF1 1167..1207 18/41 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1220..1272 23/55 (42%)

Return to query results.
Submit another query.