DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fs(1)h and cecr2

DIOPT Version :9

Sequence 1:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster
Sequence 2:	XP_005174419.1	Gene:	cecr2 / 799918	ZFINID:	ZDB-GENE-131121-533	Length:	1502	Species:	Danio rerio

Alignment Length:	1404	Identity:	271/1404 - (19%)
Similarity:	404/1404 - (28%)	Gaps:	539/1404 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   476 KLSDALKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYK 540
            ::.|...:..::|:.|  |.|.. ||||.:|||...  ..:||:||:.||||.|::||:::.||.
Zfish   400 EIDDDYTALYKVLEAL--KAHKD-AWPFMEPVDESY--APNYHEIIQTPMDLSTIERKLNDGEYL 459

  Fly   541 SAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDVFEMRYANIPDEPVANAAHHHGHGHGHGHG 605
            :..||.|||:|:|.||.:||..:.:...|...|:..|.
Zfish   460 AKDEFVADVKLMFGNCLEYNGEESEYTIMAESLERCFT--------------------------- 497

  Fly   606 HGHGHGHGHGHGHGHGYGGSSSLKHDASDSSSEDSSDTENESN-SDEERSARLKMLESKLLGLQE 669
                               .:.|||    ..||| .||:.|.: |.|:|..:.|....|..| .|
Zfish   498 -------------------RALLKH----FPSED-GDTDEEFHVSSEDRKDKKKNKNHKQSG-PE 537

  Fly   670 EIRKLSEEASAKK-----KAKKKLKEKKKS------------------IGGG------------- 698
            .:.:.:|:...:|     |...:.:||.||                  |..|
Zfish   538 SLIRATEQVQKRKTSNSGKGNNQQQEKPKSTLQPPPPHYSNGPPHPHNIHPGQQQRGMLHPAQQF 602

  Fly   699 ---SGSGS-ASH-----------------------------HCHATGGGAN-------------- 716
               ||.|. |.|                             |.:..|...|
Zfish   603 QRPSGPGMYAQHMMIDAQYPYPGQRPLISRPPGDHENQHVPHFNMQGSHINGPHLGTRYTVGPDG 667

  Fly   717 ------------AGGAGGPGSGGHGSVSVPGGVGSLGPGGAGGANLNALLGGSLVGHGGAAVAGG 769
                        :|...||..|.......|||:.|..|.|....:.....|.|:...|.|....|
Zfish   668 QPLQPPHQQHSYSGPTHGPSLGPRPMALQPGGLCSPPPEGNMYPSHQHPEGQSMRPMGNAYTRPG 732

  Fly   770 VPNVGALHSQV-----H--DVAMAFSQMAGGGAAAGAGFGAGVTAAGASSGGKAGTLAGAL---- 823
            ||    :||..     |  ::...:..|                     :..:..|.:|.:
Zfish   733 VP----MHSSYPPYGPHGMNIPRMWPPM---------------------NHQRQPTPSGNMMQEP 772

  Fly   824 -AAGA---------AAGAGGTTAGSGSSK--GAKSKGGRGAKGSGAGGVGASNNAAAGNAAGGAA 876
             |:|.         :..:.|.|..:|..|  .|.|:|..|.|
Zfish   773 SASGQHPYNHNMIHSQNSTGFTMANGQFKMPSANSQGPVGQK----------------------- 814

  Fly   877 GAAAGAGSVGGVGGAGAAGGGNASKRAKGSS------------SAGAGGGVGGANASAGGAGARG 929
                            ..||..||:....|.            ||.:...||
Zfish   815 ----------------LQGGPQASRLHLASMLDSPEMIALQQLSASSSHHVG------------- 850

  Fly   930 SSKKKPSQVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSLRDSNPDEI 994
                      ||.|.::....|::                               |...|:|::
Zfish   851 ----------NFQSPQQSGGNPLA-------------------------------SAEQSSPEK- 873

  Fly   995 EIDFETLKPSTLRELESYVASCLRKKTHKKPSGKSKDEQMAEKKQELEKRLQDVTGQLGASKKTA 1059
                :...||             |.|.|...|.|....:...|..         ||::..::..:
Zfish   874 ----QLHMPS-------------RDKQHTPVSSKGSSPKSGNKMS---------TGEISLTEAES 912

  Fly  1060 KKDESASSKVEAVQPANPVSSSSSSSDSSSSSSSDSSSSDSSDSEAVLVIPAPTG-------DGD 1117
            :...|.:.|.|  ||:.....:|.||.|...:.::.....|:..:....:.:..|       ||.
Zfish   913 RSYPSTTEKSE--QPSQVTGLASVSSPSKELNQNEDKHRLSNLEKIHDQLNSQLGPPNLKSVDGF 975

  Fly  1118 ERP-----PRKKKSRDSNGSNVNNPSIN------VVMGGNLPSGALSPTTMLMGLDHVVNSNTPT 1171
            ..|     |...|::|....|::. .||      ::..|:.......|..:|        .|.|.
Zfish   976 SFPLNSPQPMPHKTQDDIPLNISQ-QINKHALPQIIQNGSQRQSQNVPPQIL--------QNIPQ 1031

  Fly  1172 SQMSNMLGNANPLTAAAMLNNNNKTSLPGSNFGGAPAPGNMMHAGAGVPVAGAAVSASTGQQHNK 1236
            ....|::...:...:..:.||.   |:.|...|               |:.|....:|.|.|...
Zfish  1032 QMTENVIHQYHQSVSQQIQNNE---SVRGPQVG---------------PLHGMPQISSQGGQPGV 1078

  Fly  1237 NGPNDLSKVQPGGPINAALPPHSFA------------------------GGTATVATSQSSGGIR 1277
            :.|..||.:.|..|::..|...|.|                        |..|.:.|..:||..:
Zfish  1079 HQPATLSSLPPSHPVSHPLAQPSPADQGDQRPCEPTSRKVSDGSTASQDGSNANLRTDCTSGQYK 1143

  Fly  1278 IA--SNLHKPSGLGGGDLGEHHAALAAALTSGINSTGTAGGGINNNGGSNNNANPLGGSHGDAMV 1340
            ..  |...||      .|.....|.....|...:|.|.....:.:.|.|.....|.|..||..:.
Zfish  1144 QQPFSPESKP------PLVRQEQAPLQNQTPPTHSQGPESNNVTHYGISEPAHQPFGPHHGRPLQ 1202

  Fly  1341 NASLASLASGLKQIPQFDDPVEQSLASLEFSAGSTGKSGLTDNFLMQQHLMQPAGPQQQQQQQ-- 1403
            .::..|..|             |.|.|.|             |...|.....||..||..|.|
Zfish  1203 TSNHQSYTS-------------QGLPSHE-------------NNPNQNPAHYPAFHQQSIQYQYR 1241

  Fly  1404 ------QQQPFGHQQQQQQQQQQQQQQQQHMDYVTELLSKGAENVGGMNGNHLLNFNLDMAAAYQ 1462
                  |..|..|.|.|||||..|||:.....:.||                           ..
Zfish  1242 MATQHSQGHPSMHPQFQQQQQFYQQQRHGRPVFPTE---------------------------EW 1279

  Fly  1463 QKHPQQQQQQAHNNGFNVA----------DFGMA--GFDGLNMTAASFLDLEPSLQQQQMQQMQL 1515
            .:||.|.|....:|.:...          |.||:  |.||   :..|.  :.|:|         |
Zfish  1280 PRHPYQPQHPVMSNSYPTPSAGSFNGRHNDNGMSPHGSDG---SVGSL--MSPNL---------L 1330

  Fly  1516 QQQHHQQQQQQTHQQQQQHQQQHHQQQQQQQLTQQQLQQQQQQQQQQQHLQQQQH---------- 1570
            ....|....:.........|.:..:..::.:..::.|.........:.|...|.|
Zfish  1331 PDGSHSSSFENKEDGSPAKQARTEEPSERSESPKEILDLDSHNATARHHTSAQPHSSFPYGPRGM 1395

  Fly  1571 --QQQHHQAANKLLIIPKPIESMM----------PSPPDKQQLQQHQKVLP--PQQSPSDMKLHP 1621
              ..|...|....::...|..|..          |.|...:.||:.|. ||  |.||...|..||
Zfish  1396 HPSMQQSAAPPPHMMASGPYSSQQFSGGHFAPQNPHPHLMEALQRPQH-LPFSPGQSRMTMYRHP 1459

  Fly  1622 NAAA---------AAAVASAQAKLVQTFKANEQNLKNAS 1651
            |.|.         .|.||.      ..|::..|.|:.||
Zfish  1460 NVAGHFQGMMVPQRAVVAE------HLFRSGHQMLRTAS 1492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929
		COG5076	387..>593	CDD:227408	39/116 (34%)
		Bromo_Brdt_II_like	481..581	CDD:99930	38/99 (38%)
		BET	951..1015	CDD:293640	6/63 (10%)
		BRD4_CDT	<2026..2046	CDD:293710
cecr2	XP_005174419.1	DDT	23..63	CDD:280886
		ARGLU	202..366	CDD:291991
		Bromo_gcn5_like	403..503	CDD:99941	40/150 (27%)
		Med15	675..>1110	CDD:255446	104/608 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900