DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fs(1)h and brd3

DIOPT Version :9

Sequence 1:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster
Sequence 2:	XP_012823998.1	Gene:	brd3 / 733891	XenbaseID:	XB-GENE-492565	Length:	796	Species:	Xenopus tropicalis

Alignment Length:	1120	Identity:	418/1120 - (37%)
Similarity:	515/1120 - (45%)	Gaps:	358/1120 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EPPVEPVNGIVQPPVIPPAERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKKLNLPDYHK 75
            :.|..|.|  :..|.:..:.:|||.||||||:...|:|.:|||.|:|||.||||..|||||||||
Frog     9 QAPQGPSN--LPAPEVTNSNKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDCVKLNLPDYHK 71

  Fly    76 IIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQKIESM 140
            |||.|||||||||||||||||||.|.:|||||||.|||:|||..:|:|:|||.|||:||||:..|
Frog    72 IIKNPMDMGTIKKRLENNYYWSANECMQDFNTMFTNCYIYNKSTDDIVLMAQALEKIFLQKVAQM 136

  Fly   141 PKEELELEPVTAKGGKKKQRAP--ATPKSS-SGGAGASTGSGTSSAAVTSGPGSGSTKVSVAASS 202
            |:||:||.|...||   |.|.|  |||::. ...|.......|...|....|......|.|...|
Frog   137 PQEEVELLPPAPKG---KGRKPPTATPQAPVVREAETPVEKPTPPPAPAPAPAPAPKPVEVERVS 198

  Fly   203 AQQSGLQGATGAGGGSSSTPGTQP-GSGAGGAIAARPVSAMGGTVSSTAGGAPSIPPISTMPPHT 266
            .::              :.|..:| .....||..|..||::          :|||       |||
Frog   199 TRR--------------TEPPAEPRRERYKGATQASAVSSV----------SPSI-------PHT 232

  Fly   267 VPGSTNTTTTAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVNSSSLLDGSTAA 331
                                      |.|.:      |.||......|..|.          ||.
Frog   233 --------------------------NVAPV------ASQTPVIAATPVPTI----------TAN 255

  Fly   332 VAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAVIPPQQPAKIKK 396
            ||.|:...:|.|||          :..:|                        |:||..|...:|
Frog   256 VAPASTQPSAPAAA----------SQMVP------------------------VVPPAAPVVKRK 286

  Fly   397 GVKRKADTTTPTANAF-----ESP------YTQMDSKSAKIATRRESNRQVI--GKKGSGYNMSP 448
            ||||||||||||.:|.     |||      .:..|:|.||::.||||..:.|  .||       .
Frog   287 GVKRKADTTTPTTSAITASRSESPIPVPVSVSVSDAKLAKVSNRRESGGRPIKPPKK-------D 344

  Fly   449 LGVSGVPGLGGLVAGGVAGVAVAKNKEKLSDALKSCNEILKELFSKKHSGYAWPFYKPVDAEMLG 513
            |....||...|             .|.||::.||.|:.||||:.||||:.||||||||||||.|.
Frog   345 LEDGEVPQHAG-------------KKGKLNEHLKYCDSILKEMLSKKHAAYAWPFYKPVDAEALE 396

  Fly   514 LHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDVFE 578
            |||||||||.||||.:||||||.|||..|..||||:||:|:||||||||||:||||.||||||||
Frog   397 LHDYHDIIKHPMDLSSVKRKMDAREYADAQAFAADIRLMFSNCYKYNPPDHEVVAMARKLQDVFE 461

  Fly   579 MRYANIPDEPVANAAHHHGHGHGHGHGHGHGHGHGHGHGHGHGYGGSSSLKHDASDSSSEDSSDT 643
            ||:|.:||||:...|....                         ......|...|..:||:||..
Frog   462 MRFAKMPDEPLDPPAPPTA-------------------------AAPVVSKSTESSHTSEESSSD 501

  Fly   644 ENESNSDEERSARLKMLESKLLGLQEEIRKLSEEA--SAKKKAKKKLKEKKKSIGGGSGSGSASH 706
            .:.|:|:|||:.||..|:.:|..:.|::..||:..  ..|||.:||.|||||.
Frog   502 SDSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKK------------ 554

  Fly   707 HCHATGGGANAGGAGGPGSGGHGSVSVPGGVGSLGPGGAGGANLNALLGGSLVGHGGAAVAGGVP 771
                                                                          ...
Frog   555 --------------------------------------------------------------DKE 557

  Fly   772 NVGALHSQVHDVAMAFSQMAGGGAAAGAGFGAGVTAAGASSGGKAGTLAGALAAGAAAGAGGTTA 836
            .......:.|.|.|
Frog   558 KDKEKDKEKHKVKM--------------------------------------------------- 571

  Fly   837 GSGSSKGAKSKGGRGAKGSGAGGVGASNNAAAGNAAGGAAGAAAGAGSVGGVGGAGAAGGGNASK 901
                .:..|.|..:.||                                       ......|..
Frog   572 ----EEEKKIKAAQPAK---------------------------------------PVPPKKAPT 593

  Fly   902 RAKGSSSAGAGGGVGGANASAGGAGARGSSKKKPSQVMNFDSEEEDTAKPMSYDEKRQLSLDINK 966
            :...|::|.|......:||:|.....:...|:.||..  :|||||:.:.||:||||||||||||:
Frog   594 KKASSTTASATTIAAASNATANSKQPKKGGKQPPSAA--YDSEEEEESLPMTYDEKRQLSLDINR 656

  Fly   967 LPGDKLGRVVHIIQNREPSLRDSNPDEIEIDFETLKPSTLRELESYVASCLRKK-------THKK 1024
            |||:||||||||||:||||||||||||||||||||||:||||||.||.|||:||       :.||
Frog   657 LPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKK 721

  Fly  1025 PSGKSKDEQMAEKKQELEKRLQDVTGQLGASKKTAKKDESASSKVEAVQPANPVSSSSSSSDSSS 1089
            .:.|||:|...|||:|||||||||:|.|. :||..||:::.|.   |....:.:|||||||:|.|
Frog   722 QAVKSKEELAQEKKRELEKRLQDVSGHLN-NKKAQKKEKTGSG---AAGGPSRLSSSSSSSESGS 782

  Fly  1090 SSSSDSSSSDSSDSE 1104
            |||| .|||||||||
Frog   783 SSSS-GSSSDSSDSE 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	77/105 (73%)
		COG5076	387..>593	CDD:227408	121/218 (56%)
		Bromo_Brdt_II_like	481..581	CDD:99930	77/99 (78%)
		BET	951..1015	CDD:293640	57/63 (90%)
		BRD4_CDT	<2026..2046	CDD:293710
brd3	XP_012823998.1	Bromo_Brdt_I_like	30..136	CDD:99929	77/105 (73%)
		Bromo_Brdt_II_like	363..464	CDD:99930	77/100 (77%)
		BET	641..705	CDD:374956	57/63 (90%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4178
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	693	1.000	Inparanoid score	I670
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	1	1.000	-	-		otm48264
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X197
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050