Protein Alignment fs(1)h and BRDT

DIOPT Version :10

• Sequence 1: NP_001259321.1
• Gene: fs(1)h / 31722
• FlyBaseID: FBgn0004656
• Length: 2046
• Species: Drosophila melanogaster
• Sequence 2: NP_001229735.2
• Gene: BRDT / 676
• HGNCID: 1105
• Length: 951
• Species: Homo sapiens
• Alignment Length: 1188
• Identity: 376/1188 - (31%)
• Similarity: 479/1188 - (40%)
• Gaps: 497/1188 - (41%)

  Fly    20 IVQPPVIPP----AERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKKLNLPDYHKIIKQP 80
            ||.||  ||    .::.||.|||||||.|.|:|.:|||.||||||:||||.||.||||:.|||.|
Human    11 IVNPP--PPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNP 73

  Fly    81 MDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQKIESMPKEEL 145
            ||:.||||||||.||..|.|.|:||||||:|||:|||||:|:|:|||.|||:|:||:..||:||
Human    74 MDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEE- 137

  Fly   146 ELEPVTAKGGKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGSGSTKVSVAASSAQQSGLQG 210
              :.|..|...||.:|                              |.|:.::|.|||::.....
Human   138 --QVVGVKERIKKGKA------------------------------GGTQQNIAVSSAKEKSSPS 170

  Fly   211 ATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPSIPPISTMPPHTVPGSTNTTT 275
            ||.........|..                               .|..|..|.:.|.|:
Human   171 ATEKVFKQQEIPSV-------------------------------FPKTSISPLNVVQGA----- 199

  Fly   276 TAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVNSSSLLDGSTAAVAAAAAAAA 340
                                                      :|||||
Human   200 ------------------------------------------SVNSSS----------------- 205

  Fly   341 AAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAVIPPQQPAKIKKGVKRKADTT 405
                                                            |..|::.||||||||||
Human   206 ------------------------------------------------QTAAQVTKGVKRKADTT 222

  Fly   406 TPTANA------FESPYTQMDSKSAKIATRRES-NRQVIGKKGSGYNMSPLGVSGVPGLGGLVAG 463
            ||..:|      |...:|:   ||..:...:|: .:.|:......||
Human   223 TPATSAVKASSEFSPTFTE---KSVALPPIKENMPKNVLPDSQQQYN------------------ 266

  Fly   464 GVAGVAVAKNKEKLSDALKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLG 528
                  |.|. .|:::.|:.|:|||||:.:|||..||||||.|||...||||:|:|::|.|||||
Human   267 ------VVKT-VKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLG 324

  Fly   529 TVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDVFEMRYANIPDEPVANAA 593
            |:|.||||:|||.|.:|||||||:|.||||||||||:||.|.|.||||||..::.||.|||.:..
Human   325 TIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMP 389

  Fly   594 HHHGHGHGHGHGHGHGHGHGHGHGHGHGYGGSSSLKHDAS-----DSSSEDSSDTENESNSDEER 653
            ..:                               :|.|.:     ::::|.||:..:..:|::||
Human   390 LCY-------------------------------IKTDITETTGRENTNEASSEGNSSDDSEDER 423

  Fly   654 SARLKMLESKLLGLQEEIRKLSEEASAK--KKAKKKLKEKKKSIGGGSGSGSASHHCHATGGGAN 716
            ..||..|:.:|..:.::::.||:....|  ||.:|..|||||.
Human   424 VKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKE---------------------- 466

  Fly   717 AGGAGGPGSGGHGSVSVPGGVGSLGPGGAGGANLNALLGGSLVGHGGAAVAGGVPNVGALHSQVH 781
                                                                             
Human   467 ----------------------------------------------------------------- 466

  Fly   782 DVAMAFSQMAGGGAAAGAGFGAGVTAAGASSGGKAGTLAGALAAGAAAGAGGTTAGSGSSKGAKS 846
                                                                             
Human   467 ----------------------------------------------------------------- 466

  Fly   847 KGGRGAKGSGAGGVGASNNAAAGNAAGGAAGAAAGAGSVGGVGGAGAAGGGNASK-----RAKGS 906
                        .|..||.                                |..|     |.|..
Human   467 ------------KVNNSNE--------------------------------NPRKMCEQMRLKEK 487

  Fly   907 SSAGAGGGVGGANASAGGAGARGSSKKKPSQVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDK 971
            |.                   |...||:..|.:...||:||.||||:|||||||||:||||||||
Human   488 SK-------------------RNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDK 533

  Fly   972 LGRVVHIIQNREPSLRDSNPDEIEIDFETLKPSTLRELESYVASCLRKKTHKKPSGK---SKDEQ 1033
            |||||||||:|||||.:||||||||||||||.|||||||.||::||||:..|.|:.|   ||:|.
Human   534 LGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEEL 598

  Fly  1034 MAEKKQELEKRLQDVTGQLGASKKTAKKDESASSK-VEAVQPANPVSSSSSSSDSSSSSSSDSSS 1097
            .::|||||||||.||..||.:.|:..|.|::..|| ||.|...:..|||||||..|.|||||.||
Human   599 HSQKKQELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSS 663

  Fly  1098 SDSSDSEAVLVIPAPTGDGDERPPRKKKSRDSNGSNVNNPSI------NVVMGGNLPSGALSPTT 1156
            |||||||:.: .|..|    |..|....|:: |...:.|..|      .|...|.......|..|
Human   664 SDSSDSESEM-FPKFT----EVKPNDSPSKE-NVKKMKNECIPPEGRTGVTQIGYCVQDTTSANT 722

  Fly  1157 MLMGLDHVVNSNTPTSQM 1174
            .|      |:..||:..|
Human   723 TL------VHQTTPSHVM 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	74/105 (70%)
		COG5076	387..>593	CDD:227408	100/212 (47%)
		Bromo_Brdt_II_like	481..581	CDD:99930	69/99 (70%)
		BET	951..1015	CDD:435704	56/63 (89%)
		BRD4_CDT	<2026..2046	CDD:465349
BRDT	NP_001229735.2	Bromo_Brdt_I_like	27..133	CDD:99929	74/105 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..232		15/25 (60%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:22971749	213..224		10/10 (100%)
		Bromo_Brdt_II_like	276..377	CDD:99930	69/100 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..424		5/24 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	448..515		28/281 (10%)
		BET	513..575	CDD:435704	54/61 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	614..702		40/93 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	886..928
		BRD4_CDT	909..951	CDD:465349