DRSC/TRiP Functional Genomics Resources

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Protein Alignment fs(1)h and BRDT

DIOPT Version :9

Sequence 1:NP_001259321.1 Gene:fs(1)h / 31722 FlyBaseID:FBgn0004656 Length:2046 Species:Drosophila melanogaster
Sequence 2:NP_001229735.2 Gene:BRDT / 676 HGNCID:1105 Length:951 Species:Homo sapiens


Alignment Length:1188 Identity:376/1188 - (31%)
Similarity:479/1188 - (40%) Gaps:497/1188 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 IVQPPVIPP----AERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKKLNLPDYHKIIKQP 80
            ||.||  ||    .::.||.|||||||.|.|:|.:|||.||||||:||||.||.||||:.|||.|
Human    11 IVNPP--PPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNP 73

  Fly    81 MDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQKIESMPKEEL 145
            ||:.||||||||.||..|.|.|:||||||:|||:|||||:|:|:|||.|||:|:||:..||:|| 
Human    74 MDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEE- 137

  Fly   146 ELEPVTAKGGKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGSGSTKVSVAASSAQQSGLQG 210
              :.|..|...||.:|                              |.|:.::|.|||::.....
Human   138 --QVVGVKERIKKGKA------------------------------GGTQQNIAVSSAKEKSSPS 170

  Fly   211 ATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPSIPPISTMPPHTVPGSTNTTT 275
            ||.........|..                               .|..|..|.:.|.|:     
Human   171 ATEKVFKQQEIPSV-------------------------------FPKTSISPLNVVQGA----- 199

  Fly   276 TAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVNSSSLLDGSTAAVAAAAAAAA 340
                                                      :|||||                 
Human   200 ------------------------------------------SVNSSS----------------- 205

  Fly   341 AAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAVIPPQQPAKIKKGVKRKADTT 405
                                                            |..|::.||||||||||
Human   206 ------------------------------------------------QTAAQVTKGVKRKADTT 222

  Fly   406 TPTANA------FESPYTQMDSKSAKIATRRES-NRQVIGKKGSGYNMSPLGVSGVPGLGGLVAG 463
            ||..:|      |...:|:   ||..:...:|: .:.|:......||                  
Human   223 TPATSAVKASSEFSPTFTE---KSVALPPIKENMPKNVLPDSQQQYN------------------ 266

  Fly   464 GVAGVAVAKNKEKLSDALKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLG 528
                  |.|. .|:::.|:.|:|||||:.:|||..||||||.|||...||||:|:|::|.|||||
Human   267 ------VVKT-VKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLG 324

  Fly   529 TVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDVFEMRYANIPDEPVANAA 593
            |:|.||||:|||.|.:|||||||:|.||||||||||:||.|.|.||||||..::.||.|||.:..
Human   325 TIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMP 389

  Fly   594 HHHGHGHGHGHGHGHGHGHGHGHGHGHGYGGSSSLKHDAS-----DSSSEDSSDTENESNSDEER 653
            ..:                               :|.|.:     ::::|.||:..:..:|::||
Human   390 LCY-------------------------------IKTDITETTGRENTNEASSEGNSSDDSEDER 423

  Fly   654 SARLKMLESKLLGLQEEIRKLSEEASAK--KKAKKKLKEKKKSIGGGSGSGSASHHCHATGGGAN 716
            ..||..|:.:|..:.::::.||:....|  ||.:|..|||||.                      
Human   424 VKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKE---------------------- 466

  Fly   717 AGGAGGPGSGGHGSVSVPGGVGSLGPGGAGGANLNALLGGSLVGHGGAAVAGGVPNVGALHSQVH 781
                                                                             
Human   467 ----------------------------------------------------------------- 466

  Fly   782 DVAMAFSQMAGGGAAAGAGFGAGVTAAGASSGGKAGTLAGALAAGAAAGAGGTTAGSGSSKGAKS 846
                                                                             
Human   467 ----------------------------------------------------------------- 466

  Fly   847 KGGRGAKGSGAGGVGASNNAAAGNAAGGAAGAAAGAGSVGGVGGAGAAGGGNASK-----RAKGS 906
                        .|..||.                                |..|     |.|..
Human   467 ------------KVNNSNE--------------------------------NPRKMCEQMRLKEK 487

  Fly   907 SSAGAGGGVGGANASAGGAGARGSSKKKPSQVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDK 971
            |.                   |...||:..|.:...||:||.||||:|||||||||:||||||||
Human   488 SK-------------------RNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDK 533

  Fly   972 LGRVVHIIQNREPSLRDSNPDEIEIDFETLKPSTLRELESYVASCLRKKTHKKPSGK---SKDEQ 1033
            |||||||||:|||||.:||||||||||||||.|||||||.||::||||:..|.|:.|   ||:|.
Human   534 LGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEEL 598

  Fly  1034 MAEKKQELEKRLQDVTGQLGASKKTAKKDESASSK-VEAVQPANPVSSSSSSSDSSSSSSSDSSS 1097
            .::|||||||||.||..||.:.|:..|.|::..|| ||.|...:..|||||||..|.|||||.||
Human   599 HSQKKQELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSS 663

  Fly  1098 SDSSDSEAVLVIPAPTGDGDERPPRKKKSRDSNGSNVNNPSI------NVVMGGNLPSGALSPTT 1156
            |||||||:.: .|..|    |..|....|:: |...:.|..|      .|...|.......|..|
Human   664 SDSSDSESEM-FPKFT----EVKPNDSPSKE-NVKKMKNECIPPEGRTGVTQIGYCVQDTTSANT 722

  Fly  1157 MLMGLDHVVNSNTPTSQM 1174
            .|      |:..||:..|
Human   723 TL------VHQTTPSHVM 734

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fs(1)hNP_001259321.1 Bromo_Brdt_I_like 34..140 CDD:99929 74/105 (70%)
COG5076 387..>593 CDD:227408 100/212 (47%)
Bromo_Brdt_II_like 481..581 CDD:99930 69/99 (70%)
BET 951..1015 CDD:293640 56/63 (89%)
BRD4_CDT <2026..2046 CDD:293710
BRDTNP_001229735.2 Bromo_Brdt_I_like 27..133 CDD:99929 74/105 (70%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 206..232 15/25 (60%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:22971749 213..224 10/10 (100%)
Bromo_Brdt_II_like 276..377 CDD:99930 69/100 (69%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 399..424 5/24 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 448..515 28/281 (10%)
BET 513..575 CDD:293640 54/61 (89%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..702 40/93 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 886..928
BRD4_CDT 909..951 CDD:293710
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000322
OrthoInspector 1 1.000 - - otm41060
orthoMCL 1 0.900 - - OOG6_100249
Panther 1 1.100 - - O PTHR22880
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3378
SonicParanoid 1 1.000 - - X197
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.800

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