Protein Alignment fs(1)h and BRD2

DIOPT Version :10

• Sequence 1: NP_001259321.1
• Gene: fs(1)h / 31722
• FlyBaseID: FBgn0004656
• Length: 2046
• Species: Drosophila melanogaster
• Sequence 2: NP_001186384.1
• Gene: BRD2 / 6046
• HGNCID: 1103
• Length: 836
• Species: Homo sapiens
• Alignment Length: 1168
• Identity: 436/1168 - (37%)
• Similarity: 531/1168 - (45%)
• Gaps: 446/1168 - (38%)

  Fly     3 SSEPPPRYEPPVEPVNGIVQPPVIPPAERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKK 67
            :|.|..:..|...|      ||.:...::|||.|||||||.|.|||.:|||.|:|||:|||||.|
Human    49 ASVPALQLTPANPP------PPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK 107

  Fly    68 LNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEKV 132
            |.||||||||||||||||||:||||||||:|.|.:|||||||.|||:||||.:|:|:|||||||:
Human   108 LGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKI 172

  Fly   133 FLQKIESMPKEELELEPVTAKGGKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGSGSTKVS 197
            ||||:.|||:||.||.....|...||              ||.
Human   173 FLQKVASMPQEEQELVVTIPKNSHKK--------------GAK---------------------- 201

  Fly   198 VAASSAQQSGLQGATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPSIPPISTM 262
                                                     ::|:.|:|:|    |..:|.:|::
Human   202 -----------------------------------------LAALQGSVTS----AHQVPAVSSV 221

  Fly   263 -------PPHTVPGSTNTTTTAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVN 320
                   ||..:|      ||.:  .:..|...     ::.|:.||.:||.
Human   222 SHTALYTPPPEIP------TTVL--NIPHPSVI-----SSPLLKSLHSAGP-------------- 259

  Fly   321 SSSLLDGSTAAVAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAV 385
                                                   |.:||.||
Human   260 ---------------------------------------PLLAVTAA------------------ 267

  Fly   386 IPPQQPAKIKKGVKRKADTTTPTANAF------ESPYTQMDSKSAKI-ATRRESNRQV------- 436
             ||.||...||||||||||||||..|.      .||...::.|:|:: ..||||.|.:
Human   268 -PPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDL 331

  Fly   437 --------IGKKGSGYNMSPLGVSGVPGLGGLVAGGVAGVAVAKNKEKLSDALKSCNEILKELFS 493
                    ..|||                                  |||:.||.||.|||||.|
Human   332 PDSQQQHQSSKKG----------------------------------KLSEQLKHCNGILKELLS 362

  Fly   494 KKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYK 558
            |||:.|||||||||||..|||||||||||.||||.||||||:||:|:.|.||||||||:|:||||
Human   363 KKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYK 427

  Fly   559 YNPPDHDVVAMGRKLQDVFEMRYANIPDEPV------ANAAHHHGHGHGHGHGHGHGHGHGHGHG 617
            |||||||||||.||||||||.|||.:||||:      .:.|...|....
Human   428 YNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKS---------------- 476

  Fly   618 HGHGYGGSSSLKHDASDSSS-----EDSSDTENE----SNSDEERSARLKMLESKLLGLQEEIRK 673
                 ...||.:..:|:|||     ||..|.|.|    |:|:|||:.||..|:.:|..:.|::..
Human   477 -----SSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAA 536

  Fly   674 LSEEASAKKKAKKKLKEKKKSIGGGSGSGSASHHCHATGGGANAGGAGGP------------GSG 726
            ||:...:|.|.|::.|||||       ...|..|....|...:..|...|            |||
Human   537 LSQGPISKPKRKREKKEKKK-------KRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSG 594

  Fly   727 GHGSVSVPGGVGSLGPGGAGGANLNALLGGSLVGHGGAAVAGGVPNVGALHSQVHDVAMAFSQMA 791
                    ||..:|||.|.|.:      |||     |..:..||        |..|:
Human   595 --------GGSAALGPSGFGPS------GGS-----GTKLQAGV--------QWRDL-------- 624

  Fly   792 GGGAAAGAGFGAGVTAAGASSGGKAGTLAGALAAGAAAGAGGTTAGSGSSKGAKSKGGRGAKGSG 856
                                     |.|...|.                          |.|...
Human   625 -------------------------GLLQPPLL--------------------------GFKRFS 638

  Fly   857 AGGVGASNNAAAGNAAGGAAGAAAGAGSVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVGGANAS 921
            ...:.:|.:......|...|..|...|
Human   639 CLSLPSSQDYRLPKKATKTAPPALPTG-------------------------------------- 665

  Fly   922 AGGAGARGSSKKKPSQVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSL 986
                               :|||||:.::|||||||||||||||||||:||||||||||.|||||
Human   666 -------------------YDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSL 711

  Fly   987 RDSNPDEIEIDFETLKPSTLRELESYVASCLRKK-----THKKPSGKSKDEQMAEKKQELEKRLQ 1046
            |||||:||||||||||||||||||.||.||||||     |.|||.||:|:|...|||:|||||||
Human   712 RDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQ 776

  Fly  1047 DVTGQLGASKKTAK----KDESASSKVEAVQPANPVSSSSSSSDSSSSSSSDSSSSDSSDSEA 1105
            ||:|||.::||..|    |.||:|::..||   :.:|:||||||||||||| |||||:|||::
Human   777 DVSGQLNSTKKPPKKANEKTESSSAQQVAV---SRLSASSSSSDSSSSSSS-SSSSDTSDSDS 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	81/105 (77%)
		COG5076	387..>593	CDD:227408	122/233 (52%)
		Bromo_Brdt_II_like	481..581	CDD:99930	81/99 (82%)
		BET	951..1015	CDD:435704	59/63 (94%)
		BRD4_CDT	<2026..2046	CDD:465349
BRD2	NP_001186384.1	Bromo_Brdt_I_like	74..180	CDD:99929	81/105 (77%)
		PHA03247	<216..333	CDD:223021	46/201 (23%)
		Bromo_Brdt_II_like	349..450	CDD:99930	81/100 (81%)
		BET	676..738	CDD:435704	57/61 (93%)