DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fs(1)h and Brd4

DIOPT Version :9

Sequence 1:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster
Sequence 2:	NP_001273559.1	Gene:	Brd4 / 57261	MGIID:	1888520	Length:	1401	Species:	Mus musculus

Alignment Length:	2215	Identity:	574/2215 - (25%)
Similarity:	735/2215 - (33%)	Gaps:	1015/2215 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSSEPPPRYEPPVEPVNGIVQPPVIPPAERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAK 66
            :.::|.|.......|     .||......:|.|.|||||||::.|:|.:|||.|:|||||||||.
Mouse    31 AQAQPQPANAASTNP-----PPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAV 90

  Fly    67 KLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEK 131
            |||||||:||||.|||||||||||||||||:|:|.||||||||.|||:|||||:|:|:||:.|||
Mouse    91 KLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEK 155

  Fly   132 VFLQKIESMPKEELELEPVTAKG---GKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGSGS 193
            :|||||..:|.||.|:..|.|||   |:|:....|.|       |.||...|:.|
Mouse   156 LFLQKINELPTEETEIMIVQAKGRGRGRKETGRAAKP-------GVSTVPNTTQA---------- 203

  Fly   194 TKVSVAASSAQQSGLQGATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPSI-- 256
                                     |::|.||           .|.......|.:|....|::
Mouse   204 -------------------------STSPQTQ-----------TPQQNPPPPVQATTHPFPAVTP 232

  Fly   257 -----PPISTMPPHTVPGSTNTTTTAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQ 316
                 ||:.||.|   |....|           |......|..                |.||..
Mouse   233 DLIAQPPVMTMVP---PQPLQT-----------PSPVPPQPPP----------------PPAPVP 267

  Fly   317 TAVNSSSLLDGSTAAVAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVG 381
            ..|.|..                                    |.:|..
Mouse   268 QPVQSHP------------------------------------PIIATT---------------- 280

  Fly   382 VDAVIPPQQPAKIKKGVKRKADTTTPTA--NAFESPYTQMDSKSAKIATRRESNRQVIGKK---- 440
                   .||.|.||||||||||||||.  ...|.|....:.|:||:..||||:|.|...|
Mouse   281 -------PQPVKTKKGVKRKADTTTPTTIDPIHEPPSLAPEPKTAKLGPRRESSRPVKPPKKDVP 338

  Fly   441 GSGYNMSPLGVSGVPGLGGLVAGGVAGVAVAKNKEKLSDALKSCNEILKELFSKKHSGYAWPFYK 505
            .|..:..|                       :...|:|:.||.|:.||||:|:|||:.|||||||
Mouse   339 DSQQHPGP-----------------------EKSSKISEQLKCCSGILKEMFAKKHAAYAWPFYK 380

  Fly   506 PVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMG 570
            |||.|.||||||.||||.|||:.|:|.|:::|||:.|.||.|||||:|:||||||||||:||||.
Mouse   381 PVDVEALGLHDYCDIIKHPMDMSTIKSKLESREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMA 445

  Fly   571 RKLQDVFEMRYANIPDEP------------------VANAAHHHGHGHGHGHGHGHGHGHGHGHG 617
            ||||||||||:|.:||||                  ||..:
Mouse   446 RKLQDVFEMRFAKMPDEPEEPVVTVSSPAVPPPTKVVAPPS------------------------ 486

  Fly   618 HGHGYGGSSSLKHDASDSSSEDSSDTENES-NSDEERSARLKMLESKLLGLQEEIRKLSEEASAK 681
                          :|||||:.|||:::.: :|:|||:.||..|:.:|..:.|::..||:....|
Mouse   487 --------------SSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNK 537

  Fly   682 -KKAKKKLKEKKKSIGGGSGSGSASHHCHATGGGANAGGAGGPGSGGHGSVSVPGGVGSLGPGGA 745
             ||.:|..|||||.
Mouse   538 PKKKEKDKKEKKKE--------------------------------------------------- 551

  Fly   746 GGANLNALLGGSLVGHGGAAVAGGVPNVGALHSQVHDVAMAFSQMAGGGAAAGAGFGAGVTAAGA 810
                                          .|.:..:|.
Mouse   552 ------------------------------KHKKKEEVE-------------------------- 560

  Fly   811 SSGGKAGTLAGALAAGAAAGAGGTTAGSGSSKGAKSKGGRGAKGSGAGGVGASNNAAAGNAAGGA 875
                                         .:|.:|:|.....|..       .||::..|.
Mouse   561 -----------------------------ENKKSKTKELPPKKTK-------KNNSSNSNV---- 585

  Fly   876 AGAAAGAGSVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVGGANASAGGAGARGSSKKKPSQVM- 939
                                                                   |||:|....
Mouse   586 -------------------------------------------------------SKKEPVPTKT 595

  Fly   940 ----NFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSLRDSNPDEIEIDFET 1000
                .::|||||..|||||:||||||||||||||:||||||||||:|||||::||||||||||||
Mouse   596 KPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFET 660

  Fly  1001 LKPSTLRELESYVASCLRKKTHKKPSGKSKDEQMAEKKQELEKRLQDVTGQLGASKKTAKKDESA 1065
            ||||||||||.||.||||||  :||        .|||...:                      :.
Mouse   661 LKPSTLRELERYVTSCLRKK--RKP--------QAEKVDVI----------------------AG 693

  Fly  1066 SSKVEAVQPANPVSSSSSSSDSSSSSSSDSSSSDSSDSEAVLV---------------------- 1108
            |||::..            |.|.|.|:|:||||||.|||..:.
Mouse   694 SSKMKGF------------SSSESESTSESSSSDSEDSETEMAPKSKKKGHTGRDQKKHHHHHHP 746

  Fly  1109 ----IPAPTGDGDERPPRKKKSRDSNGSNVNNPSINVVMGGNLPSGALSPTTMLMGLDHVVNSNT 1169
                .|||.......||::..           |..........|.....|.:|.......:.|:.
Mouse   747 QMQPAPAPVPQQPPPPPQQPP-----------PPPPPQQQQQQPPPPPPPPSMPQQTAPAMKSSP 800

  Fly  1170 P---TSQMSNMLGNANPLTAAAMLNNNNKTSLPGSNFG----------GAPAPGNMMHAGAGVPV 1221
            |   |:|:..:                 :..||||.|.          ..|.|....|    :|.
Mouse   801 PPFITAQVPVL-----------------EPQLPGSVFDPIGHFTQPILHLPQPELPPH----LPQ 844

  Fly  1222 AGAAVSASTGQQHNKNGPNDLSKV---QPGGPIN--AALPPHSFAGGTATVATSQSSGGIRIASN 1281
            .....:.....||....|..|...   ||..|.|  |||||
Mouse   845 PPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPP------------------------ 885

  Fly  1282 LHKPSGLGGGDLGEHHAALAAALTSGINSTGTAGGGINNNGGSNNNANPLGGSHGDAMVNASLAS 1346
              ||:         ...|::.||                       |.|      ..:....:|
Mouse   886 --KPT---------RPPAVSPAL-----------------------AQP------PLLPQPPMA- 909

  Fly  1347 LASGLKQIPQF----DDPVEQSLASLEFSAGSTGKSGLTDNFLMQQHLMQPAGPQQQQQQQQQQ- 1406
                  |.||.    ::|....|.|::...           :|.|...:||..|.....:.|.|
Mouse   910 ------QPPQVLLEDEEPPAPPLTSMQMQL-----------YLQQLQKVQPPTPLLPSVKVQSQP 957

  Fly  1407 -----PFGHQQQQQQQ-----------QQQQQQQQQHMDYVTELLSKGAENVGGMNGNHLLNFNL 1455
                 |..|...||||           |.|...||||......:              ||.  ::
Mouse   958 PPPLPPPPHPSVQQQQLQPQPPPPPPPQPQPPPQQQHQPPPRPV--------------HLP--SM 1006

  Fly  1456 DMAAAYQQKHPQQQQQQAHNNGFNVADFGMAGFDGLNMTAASFLDLEPSLQQQQMQQMQLQQ--Q 1518
            ..:|..||..|...||..|.                          .|..|....|..:.||  |
Mouse  1007 PFSAHIQQPPPPPGQQPTHP--------------------------PPGQQPPPPQPAKPQQVIQ 1045

  Fly  1519 HHQQQQQQTHQQQQQHQQQH----------H--QQQQQQQLTQQQLQQQQQQQQQQQH------- 1564
            ||...:   |.:...:...|          |  |..|.|.||.|...||..|.::|..
Mouse  1046 HHPSPR---HHKSDPYSAGHLREAPSPLMIHSPQMPQFQSLTHQSPPQQNVQPKKQVKGRAEPQP 1107

  Fly  1565 ----LQQQQHQQQHHQAANKLL---------IIPKPI-------------------ESMMPSPPD 1597
                :.|.|.......||..:|         :.|:|:                   .|:.|.||.
Mouse  1108 PGPVMGQGQGCPPASPAAVPMLSQELRPPSVVQPQPLVVVKEEKIHSPIIRSEPFSTSLRPEPPK 1172

  Fly  1598 KQQLQQHQKVLP--PQQSPSDMK----LHPNAAAAAAVASAQAKLVQTFKA-----NEQNLKNAS 1651
            ..:..:....||  |:..|.|:.    ..|..:|....|..:.|..|..|.     .:..:||..
Mouse  1173 HPENIKAPVHLPQRPEMKPVDIGRPVIRPPEQSAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMG 1237

  Fly  1652 SWSSLASANSPQSHTSSSSSSSKAKPAMDSFQQFRNKAKERDRLKLLEAAEKEKKNQKEAAEKEQ 1716
            ||:||.     |.|.::.||:  ||.:.|||:.||..|:|:      |..||..|.|.|.||||:
Mouse  1238 SWASLV-----QKHPTTPSST--AKSSSDSFEHFRRAAREK------EEREKALKAQAEHAEKEK 1289

  Fly  1717 QRKHHKSSSSSLTSAAVAQAAAIAAATAAAAVTLGAAAAAALASSASNPSGGSSSGGAGSTSQQA 1781
            :|...:...|.....|:.||.
Mouse  1290 ERLRQERMRSREDEDALEQAR-------------------------------------------- 1310

  Fly  1782 ITGDRDRDRDRERERERSGSGGGQSGNGNNSSNSANSNGPGSAGSGGSGGGGGSGPASAGGPNSG 1846
                  |..:..|.|:.
Mouse  1311 ------RAHEEARRRQE------------------------------------------------ 1321

  Fly  1847 GGGTANSNSGGGGGGGGPALLNAGSNSNSGVGSGGAASSNSNSSVGGIVGSGGPGSNSQGSSGGG 1911

Mouse  1322 ----------------------------------------------------------------- 1321

  Fly  1912 GGGPASGGGMGSGAIDYGQQVAVLTQVAANAQAQHVAAAVAAQAILAASPLGAMESGRKSVHDAQ 1976
                              ||.....|.....|.|..||||||    |::|
Mouse  1322 ------------------QQQQQQQQRQEQQQQQQQAAAVAA----ASAP--------------- 1349

  Fly  1977 PQISRVEDIKASPGGQGQSSPAQQSPQDRAAAKRAEQRRAEQERRRREALAGQIDMNMQSDLMAA 2041
                           |.|||    .||.....:|...|:.|||||||||:|..||||.||||::.
Mouse  1350 ---------------QAQSS----QPQSMLDQQRELARKREQERRRREAMAATIDMNFQSDLLSI 1395

  Fly  2042 FEETL 2046
            |||.|
Mouse  1396 FEENL 1400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	81/105 (77%)
		COG5076	387..>593	CDD:227408	114/229 (50%)
		Bromo_Brdt_II_like	481..581	CDD:99930	73/99 (74%)
		BET	951..1015	CDD:293640	57/63 (90%)
		BRD4_CDT	<2026..2046	CDD:293710	12/19 (63%)
Brd4	NP_001273559.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		6/31 (19%)
		Bromo_Brdt_I_like	58..164	CDD:99929	81/105 (77%)
		Bromo_Brdt_II_like	355..456	CDD:99930	73/100 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..617		55/394 (14%)
		NPS region. /evidence=ECO:0000250	486..505		8/56 (14%)
		BID region. /evidence=ECO:0000250	526..581		19/197 (10%)
		BET	611..675	CDD:407211	57/63 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..1126		128/652 (20%)
		PHA03247	<793..1231	CDD:223021	111/585 (19%)
		C-terminal (CTD) region. /evidence=ECO:0000250	1051..1401		115/585 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1156..1378		79/453 (17%)
		TPH	<1267..1308	CDD:404709	15/46 (33%)
		BRD4_CDT	1359..1401	CDD:407248	24/42 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I4071
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	653	1.000	Inparanoid score	I776
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	1	1.000	-	-		otm43131
orthoMCL	1	0.900	-	-		OOG6_100249
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X197
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.820