back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fs(1)h and baz2ba

DIOPT Version :9

Sequence 1:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster
Sequence 2:	XP_021332704.1	Gene:	baz2ba / 561095	ZFINID:	ZDB-GENE-070615-37	Length:	2318	Species:	Danio rerio

Alignment Length:	1350	Identity:	252/1350 - (18%)
Similarity:	412/1350 - (30%)	Gaps:	438/1350 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   823 LAAGAAAGAGGTTAGSGSSKGAKSKGGRGAKGSGAGGVGASNNAAAGNAAGGA-AGAAAGAGSVG 886
            ||:.:|..|...||.|.||..:.|               :|::.||.||.... .||.|..|:.|
Zfish     7 LASPSATPASVHTATSVSSSSSSS---------------SSSSTAASNAKSSLNHGATASLGTCG 56

  Fly   887 GVGGAGAAGGGNASKRAKGSSSAGA--------------------GGGVGGANASAG-------G 924
            .:  .|..|.......:..:|...|                    .||:||...||.       |
Zfish    57 PL--FGLTGSDQPFSVSSVTSVPSAYPLMAHPAFGLLSPATVRPEFGGLGGLGVSAALAAHPQLG 119

  Fly   925 A------GARGSSKKKPSQVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNRE 983
            |      .|....:..|:....|.......|.|:...|....:   :|.|              .
Zfish   120 AFSEWWRAAEAHGRSPPTFFPPFLGLPPIFAPPLHNHEANPYT---SKTP--------------S 167

  Fly   984 PSLRDSNPDEIEIDFETLKPSTLRELESYVAS---CLRKKTHKKP-SGKSKDEQMAEKKQELEKR 1044
            .|.:.|......::..:|.||..:...|..||   .||...|.:. :.|::|.:.:.....
Zfish   168 KSSQASKGVNGAVNGRSLSPSVAKGTVSASASPSPALRPPEHSRTLNAKARDRKASHHSNS---- 228

  Fly  1045 LQDVTGQLGASKKTAKKDESASSKVEAVQPANPVSSSSSS----SDSSSSSSSDSSSSDSSDSEA 1105
                ||:| ..|.:.|..|..|.|.:...|....|.|.||    ||..|||..|....:..|.|
Zfish   229 ----TGEL-QEKPSQKTKEKKSRKKQVEGPGVSESESGSSLDTDSDGVSSSDMDDLGEEDDDDE- 287

  Fly  1106 VLVIPAPTGDGDERPPRKKKSRDSNGSNVNNPSINVVMGGNLPSGALSPTTMLMGLDHVVNSNTP 1170
                     |.||:....::| ||.........:.:|
Zfish   288 ---------DEDEQSKDSEES-DSEKERQKKKKMKIV---------------------------- 314

  Fly  1171 TSQMSNMLGNANPLTAAAMLNNNNKTS-LPGSNF-GGAP---APGNMMHAGAGVPVAGAAVSAST 1230
                          ||.:.|:...|:. |...:| ||||   .|...:|.....|....:...|.
Zfish   315 --------------TAISGLSKKEKSKLLEAQDFRGGAPLDATPPLHLHRSPPPPAHSQSPLLSV 365

  Fly  1231 GQQHNKNGPNDLSKVQPGGPINAALPPHSFAGGTATVATSQSSGGIRIASNLHKPSGLGGGDLGE 1295
            .....:..|...|.:|..|...|:.|       .|.:|.|:     |.||..|.|         :
Zfish   366 SGSRARERPLHTSVIQSTGLAAASKP-------LALIAQSR-----RDASPKHSP---------Q 409

  Fly  1296 HHAALAAALTSGINSTGTAGGGINNNGGSNNNANPLGGSHGDAMVNASLA----SLASGLKQIPQ 1356
            |       |||....|              .:|.||..|.....::...:    |:.|..|.:|.
Zfish   410 H-------LTSSSPKT--------------LSAKPLPSSPQPLPLSLCSSPKPLSVPSPPKPLPL 453

  Fly  1357 FDDPVEQSLASLEFSAGSTGKS------GLTDNFLMQQHLMQ-PAGPQQQQQQQQQQPFGHQQQQ 1414
            ...|....|.....:..|:.||      .||...|::..|.| .|..:.:|...|.|||..|.::
Zfish   454 SSSPKPPPLTPSLKAQASSRKSQSPALDALTSRKLLESSLAQVTADYRLKQSFLQDQPFPLQLKK 518

  Fly  1415 QQQQQQQQQQQQHMDYVTELLSKGAENVGGMNGNHLLNFNLDMAAAYQQKHPQQQQQQ-----AH 1474
            ||...:..::.      ..|.|..:..    :.:.:|...|....:.:.|.|..|...     :|
Zfish   519 QQNPFKSNKRS------APLTSSSSST----SSSSVLPLKLSSEVSGRTKPPTTQSVSSSLPFSH 573

  Fly  1475 NNGFNVADFGMAGFDGLNMTAASFLDLEPSLQQQQMQQMQLQQQHHQQQQQQTHQQQQQHQQQHH 1539
                     |:.|....|....|..|:..:|..:....:.:......::...:........::..
Zfish   574 ---------GLLGLSQPNGVIQSTQDVPLALTTKTRSDVPVNLSTGGRKSPASASPTPNRSREPR 629

  Fly  1540 QQQQQQQLTQQQLQQQQQQQQQQQHLQQQQHQQQHHQAANKLLIIPKPIESMMPSPPDKQQLQQH 1604
            :.:..:.|       :..:...|.||.|.......|..|          |..:||..|.....:.
Zfish   630 KTKTPKAL-------EAWKGLSQNHLVQSLVDLFQHSGA----------EQEVPSSKDSDDSAED 677

  Fly  1605 QKVLPPQQSPSDMKLHPNAAAAAAVASAQAKLVQTFKANEQNLKNASSWSSLASANSPQSHTSSS 1669
            :     .....|::                        :|::.....|..||:.        |.|
Zfish   678 E-----DDEDDDVE------------------------DEEDDDEEDSDDSLSE--------SDS 705

  Fly  1670 SSSSKAKPAMDSFQQFRNKAKERDRLKLLEAAEKEKKNQKEAAEKEQQ-------RKHHKSSSSS 1727
            :|.|:                       :..:|..||.:|:|:..|..       :|.:||..:|
Zfish   706 NSDSE-----------------------MNGSEGTKKKRKDASAAEMDTDGEKTPQKLNKSLLNS 747

  Fly  1728 LTSAAVAQA----AAIAAATAAAAVTLGAAAAAALASSASNPSGGSSSGGAGSTSQQAITGDRD- 1787
            .|:.:::..    ..:....:.|..|:.:::.|..:|.:|:.|.|:|   .||..::.:..:.|
Zfish   748 STNHSLSDCLPLNLQVVKPASVATPTIVSSSGAYHSSPSSSYSVGTS---PGSAKRKRVMNEDDL 809

  Fly  1788 ---RDRDRERERERSGSGGGQSGN------------------------------GNNSSNSANSN 1819
               .:...:||.......|...|:                              .:|.|.||.
Zfish   810 RIPLEMGWQRETRIKTVAGRLQGDVAYYSPCGKRLRQYPDVVKYLSRYGITDITRDNFSFSAK-- 872

  Fly  1820 GPGSAGSGGSGGGGGSGPASAGGPNSGGGGTANSNSGGGGGGGGPALLNAGSNSNSGVGSGGAAS 1884
                                                           :..|....:..|..|...
Zfish   873 -----------------------------------------------IRVGDFYEAREGPQGLQW 890

  Fly  1885 S--NSNSSVGGIVGSGG-----PGSNSQ--GSSGGGGGGPASGGGMGSGAIDY------------ 1928
            :  |....:..|:...|     |.|:.|  |||.|.|.....|.....|..::
Zfish   891 TLLNEEEVIPHILAMEGRRGRPPNSDRQQRGSSEGSGSRRRKGRPPNLGENEFPSPSEAKLLRKL 955

  Fly  1929 -GQQVA-------VLTQVAANAQAQHVAAAVAAQAILAASPLGAMESGRK-----SVHDAQPQIS 1980
             .|::|       ::.::...|.|:....|...|||:||      |..||     .:...|.:|.
Zfish   956 EAQEIARQAAQMKLMRKLEKQALARAAKEARKQQAIMAA------EERRKQKEQLKILKQQEKIK 1014

  Fly  1981 RVEDIKASPGGQGQS-SPAQQSPQDRAA-AK--RAEQRRAEQERRRREAL 2026
            |::.|:.....:.|. ..|::..::.|| ||  .||:|..|:|.||::|:
Zfish  1015 RIQQIRMEKELRAQQILEAKRKKREEAANAKMLEAEKRIKEKEMRRQQAV 1064

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.