DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fs(1)h and ep300a

DIOPT Version :9

Sequence 1:NP_001259321.1 Gene:fs(1)h / 31722 FlyBaseID:FBgn0004656 Length:2046 Species:Drosophila melanogaster
Sequence 2:XP_009304968.1 Gene:ep300a / 559273 ZFINID:ZDB-GENE-080403-16 Length:2682 Species:Danio rerio


Alignment Length:2389 Identity:469/2389 - (19%)
Similarity:713/2389 - (29%) Gaps:786/2389 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 PPPRYEPPVEPVNGIVQPPVIPPAERPGRNTNQLQYLIKTVMKVIWKHHF--------------S 56
            ||...:....|||.:....:.......|:..||...|::..|.     |.              |
Zfish   499 PPQPIQQTQRPVNTLGANSMGVNGAVGGQPQNQQSSLLQDTML-----HLNMNSQSLINDSGVGS 558

  Fly    57 WPFQQPVDAKKLNLPDYHKIIKQPM----------------DMGTIK-KRLENNYYWSAKETIQD 104
            .|...|..:..:. ..:|:.|.|.:                |...:| :|:||...::.|.....
Zfish   559 LPMANPAASGSMR-KSWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDM 622

  Fly   105 FNTMFNNCYVYNKPGEDVVVMAQTLE---KVFLQKIESMPKE----ELELEPVTAKGGKKKQRAP 162
            :.:..:....|:...|.:..:.:.||   :..|||...||.:    ...|:..||..|   |..|
Zfish   623 YESANSRAEYYHFLAEKIYKIQKELEEKRRTRLQKQGIMPSQAGMNPSGLQQATAGIG---QPGP 684

  Fly   163 ATPKSSSG-----------GAGASTGSGTSSAAVTS----------------------------- 187
            .|...|:|           |.........::|.:.|                             
Zfish   685 PTGLPSNGPLSDPSVVRPTGPNQMMNRMQNTAGMNSFGNHMGMQSMGQRSTPPLNQGSMVPGRMP 749

  Fly   188 --------------GPGSGSTKVSVAA----------SSAQQSGLQGATGAGGGSSSTPGTQPGS 228
                          ||...|:.|..|.          .:|.|.|....:....||   |..||||
Zfish   750 QPNVAQMQNQYMQTGPFQASSPVRSAGPVDLVHGGNDGAATQQGQMPLSSLPVGS---PLAQPGS 811

  Fly   229 GAGGAIAARPVSAMGGTVSSTAGGAPSIPPISTMPPHTV--------------PGSTNTTTTAMA 279
             ||||.:...|.::|.:..|      ::||.|| |.|::              |..:.|.|..  
Zfish   812 -AGGAGSGSSVGSLGPSSMS------AVPPSST-PTHSISLSHCPPVHQNSPSPAHSRTPTPT-- 866

  Fly   280 GGVGGPGAAGANPNAAALMASLLNAGQ----------TGAYP-GAPGQTAVNSSSLL-------- 325
                 ||:....|:..:|.....|..|          :|..| |.|  .||:.|.|.        
Zfish   867 -----PGSQTPQPHTPSLPHLSSNGSQQQFPPSASSDSGMQPLGTP--PAVSHSGLSTPNASQHP 924

  Fly   326 ------DGSTAAVAAAAAAAAAAAAAAGGAAGAAGGAGTI-PAVAVNAAN-----AVQAYVNAGV 378
                  .||......||..|:.::..|......:....|: |.|.|.|.:     |::....|  
Zfish   925 RTPLSHKGSLPVDGQAATPASVSSVEASFQQAPSDSTATLEPKVEVKAKDEEEEEAMEEERTA-- 987

  Fly   379 SVGVDAVIPPQQPAKIKKGVKRKADTTTPTANAFESPYTQMDSKSAKIATRRESNRQVIGKKGSG 443
                     .::.:|.::..:.|.:.........|:...:......||..:.|       ::||.
Zfish   988 ---------KEEDSKTEEKPEVKKEEPLSDGGPMETASDEDKKPEIKIEPKEE-------EEGSE 1036

  Fly   444 YNMSPLGVSGVPGLGGLVAGGVAGVAVAKNKEKL---SDALKSCNEILKELFSKKHSGYAWPFYK 505
            ...|...|||                 |.||:|:   .:..::....|:.|:  :....:.||.:
Zfish  1037 SATSQSSVSG-----------------ATNKKKIFKPEELRQALMPTLESLY--RQDPESLPFRQ 1082

  Fly   506 PVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMG 570
            |||..:||:.||.||:|.||||.|:|||:|..:|:...::..|:.|:|.|.:.||.....|....
Zfish  1083 PVDPSLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYC 1147

  Fly   571 RKLQDVFEM-----------------------------RYANIPDEPVANAAHHHGHGHGHGHG- 605
            .||.:|||.                             :...||    .:||:.........:| 
Zfish  1148 SKLAEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIP----RDAAYFSYQNSSPKYGL 1208

  Fly   606 -----HGHGHGHGHGHGHGHGYGG--------------SSSLKHDASDSSSEDSSDTE------- 644
                 |..........|.....|.              |.|:..|..:....|:.|.|       
Zfish  1209 LADRYHFCEKCFNEIQGETVSLGDDPSQPQTATIFLNISRSINKDQFEKKKNDTLDPELFVECMD 1273

  Fly   645 ------------NE----------------SNSDEERSARLKMLESKLLG----------LQEEI 671
                        ||                :.:.:|.....|.|....||          |:.:.
Zfish  1274 CGRKMHQICVLHNETIWPSGFVCDGCLKKSNKTRKENKYAAKRLPQTKLGNFLETRVNAYLKRQN 1338

  Fly   672 RKLSEEAS------AKKKAKKKLKEKKKSIGGGSGSGSASHHCHATGGGANAGGAGGPGSGGH-- 728
            ...|.|.:      ::|..:.|...|.:.:..|..|.|..:...|........|......|.|  
Zfish  1339 HPESGEVTVRVVHVSEKMVEVKPGMKSRFVDSGEMSESFPYKSKALFAFEEIDGVDVCFFGMHVQ 1403

  Fly   729 --GS-----------VSVPGGVGSLGPGGAGGANLNALLGGSL---------VGHGGA------- 764
              ||           :|....|....|........:.:|.|.|         .||..|       
Zfish  1404 EYGSDCPPPNQRRVYISYLDSVHFFQPRFLRTEVYHEILIGYLDYAKRQGFTTGHIWACPPSEGD 1468

  Fly   765 -----------------------------AVAGGVPNVGALHSQVHDVAMAFSQMAGGGAAAGAG 800
                                         |||..|         |||....|.|           
Zfish  1469 DYIFHCHPADQKIPKPKRLQEWYKKMLDKAVAERV---------VHDYKDIFKQ----------- 1513

  Fly   801 FGAGVTAAGASSGGKAGTLAGALAAGA--------------------AAGAGGTTAGSGSSKGAK 845
                .|....:|..:.....|......                    :..........|.||.||
Zfish  1514 ----ATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENSTSNESVETTKGDSKNAK 1574

  Fly   846 SKGG-RGAKGSGAGGVGASNNAAAGNAAGGAA----GAAAGAGSVGGVGGAGAAGGGNASKRAKG 905
            .|.. :.:|...:...|........|.:...:    ........|..|....||...||......
Zfish  1575 KKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLFAAPNSNALLPIVD 1639

  Fly   906 SSSAGAGGGVGGANASAGGA--------GARGSSKKKPSQVMNFDSEEED--------------T 948
            .....|...:.|.:|....|        ..|.|.......::...::.:|              |
Zfish  1640 PDPLMACDLMDGRDAFLTIARDKHLEFSSLRRSKWSTMCMLVELHNQSQDRFVYTCNECKHHVET 1704

  Fly   949 AKPMSYDEKRQLSLDINKLPG-----DKLGRVVHIIQNREPSLRDSNPDEIEIDFETLKPSTLRE 1008
            ....:..|...|.:......|     ||||..:....|.:.:....||.      ::.:.|..|.
Zfish  1705 RFHCTVCEDYDLCITCYNTKGHEHKMDKLGLGLDDESNSQVASTTQNPG------DSRRLSIQRC 1763

  Fly  1009 LESYVASC------------------------LRKKT----------------HKKPSGKSK--- 1030
            ::|.|.:|                        .::||                |.|...::|   
Zfish  1764 IQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPV 1828

  Fly  1031 ----DEQMAEKKQELEKRLQD---VTGQLGASKKTAKKDESASSKVEAVQPANPVSSSSSSSDSS 1088
                :.:...::|:|:.|||.   |..::.:.::|.::.......:.:  |.|..::..|:    
Zfish  1829 PFCLNIKQKLRQQQLQHRLQQAQMVRRRMASMQRTGQQLPGGGCGLPS--PGNGCNTGPST---- 1887

  Fly  1089 SSSSSDSSSSDSSDSEAVLVIPAPTGDGDERPPRKKKSRDSNGSNVNNPSINVVMGGNLPSGALS 1153
                                 |.|:    .:||..:............|.:     ||:||   .
Zfish  1888 ---------------------PTPS----TQPPTPQTPTQQCQPPATQPGV-----GNVPS---Q 1919

  Fly  1154 PTTMLMGLDHVVNSNTPTSQMSNMLGNA----------NPLTAAAMLNNNNKTSLPGSNFGGAPA 1208
            ....|.|:.|   ...|.|....|:.::          .|..|..:.|.||.........|.:|.
Zfish  1920 QQQQLAGMTH---QYQPISGSGGMINSSQQSMLPQQQQQPTPAQHLQNANNLPPYVQRPTGSSPL 1981

  Fly  1209 PGNMMHAGAGVPVAGAAVSASTGQQHNKNGPNDLSKVQPGGPINAALPPHSFAGGTATVA-TSQS 1272
            ..:|     |.|  |......:.||.:..|...:.:.||.||..||:   ..|.....|| |.:.
Zfish  1982 SQSM-----GKP--GMVPGGFSQQQQSNLGQPVMPQHQPPGPPPAAV---EIAMKIQRVAETQRQ 2036

  Fly  1273 SGGIRI-----ASNLHKPSGLGGGDLGEHHAALAAALTSGINSTGTAGGGINNNGGSNNNANPLG 1332
            ....:|     |..:..|.||..|...::.        .|||..||                   
Zfish  2037 MAQQKILQRNQAPGMMPPHGLHQGPQTQNQ--------MGINLPGT------------------- 2074

  Fly  1333 GSHGDAMVNASLASLASGLKQIPQFDDPVEQSLASLEFSAGSTGKSGLTDNFLMQQHLMQPAGPQ 1397
                 |||..|.|.:|....|:.|     :|.:.:........|.........:||.  |...||
Zfish  2075 -----AMVGPSQAQVAVARTQMDQ-----QQGMVTAGMQQQQPGPRSQLPQVQLQQG--QQGAPQ 2127

  Fly  1398 QQ---QQQ-------QQQQP-----FGHQ----QQQQQQQQQQQQQQQHMDYVTELLSK--GAEN 1441
            .|   |||       .||:|     .|.|    .|.||||...|.|.|....|..::|.  ||..
Zfish  2128 LQVSPQQQWTGPGMPPQQRPGVMNQMGLQGMAAPQHQQQQAVGQSQPQGNSGVMGMISSQGGAAP 2192

  Fly  1442 VGGMNGNH-------LLNFNLDMAAAYQQKHPQQQQQQ---AHNNGFNVADF------------- 1483
            .|...|||       ||.| |.:.::     |.||||.   ..:|...:|.|             
Zfish  2193 AGAGPGNHSQAALQDLLRF-LRLPSS-----PHQQQQVLSILRSNPLLMATFIRQRAPRYLGRGG 2251

  Fly  1484 ---GMAGF------------------------DGLNMTAASFLDLEPSLQQQQMQQMQ---LQQQ 1518
               |.||.                        .|::||..:.:.:.|..||||.||:|   :...
Zfish  2252 PGAGGAGVPGGPGGGPGIMDGQQMNVNPNAAQGGMHMTQGTTMQMNPLQQQQQQQQIQQRPMMSG 2316

  Fly  1519 HHQQQQQQTHQQQQQHQ--------------------QQHHQQQQQQQLTQQQLQQQQQQQQQQQ 1563
            :.|||||....||||.|                    .:.|.||||||..|||.|||||||||||
Zfish  2317 NLQQQQQMAVLQQQQQQGVMPSQGTNISNIPPQLREMMRRHLQQQQQQQQQQQQQQQQQQQQQQQ 2381

  Fly  1564 HLQQQQHQQQHHQAANKLLIIPKPIESMMPSPPDKQQLQQHQKVLPPQQ----SPSDMKLHPNAA 1624
            ..|||||||..:.|           :...|.|| :||....|..:||||    .|..::.....|
Zfish  2382 QQQQQQHQQMGNHA-----------QFQHPQPP-QQQGYLGQSGIPPQQPGQPHPGGLQQQQGGA 2434

  Fly  1625 A-------AAAVASAQAKLVQTFKANEQNLKNASSWSSLA---------SANSP--QSHTSSSSS 1671
            .       :.:|:..|.......:..:|.|:.....|::.         ....|  |......|:
Zfish  2435 QPGTQQNYSGSVSHQQVAAALQHRLQQQQLQMQQQQSAMGGYQGADGGPGGGGPLQQQQQQMQSA 2499

  Fly  1672 SSKAKPAMDSFQQFRNKAKERDRLKLLEAAEKEKKNQKEAAEKEQQRKHHKSSSSSLTSAAVAQA 1736
            ...::|.|  |||...:...:.:...|......:.|.....:.:||..........|.::...|.
Zfish  2500 PMGSQPQM--FQQAIQQRLLQQQQSHLGGGSPAQHNPMSPQQSQQQMSQSPHLQGQLPNSLGNQV 2562

  Fly  1737 AAIAAATAAAAVTLGAAAAAALASSAS----NPSGGSSSGG----------AGSTSQQAITGDRD 1787
            .:...:....:....::.:..|....|    :|..||...|          |....||.....:.
Zfish  2563 RSPQPSPRPQSQPPNSSPSPRLQPQPSPHHISPQTGSPHPGHLPQHHSGMAAPPPPQQQAQASQQ 2627

  Fly  1788 RDRDRERER------------ERSGSGG--GQSGNG---NNSSNSANSN 1819
            :.:....::            :.||.|.  ||..|.   ||....:|.|
Zfish  2628 QQQVNAMDQGPFGADQNAMLSQLSGMGALHGQGTNDMLTNNQDMGSNIN 2676

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fs(1)hNP_001259321.1 Bromo_Brdt_I_like 34..140 CDD:99929 24/139 (17%)
COG5076 387..>593 CDD:227408 54/237 (23%)
Bromo_Brdt_II_like 481..581 CDD:99930 36/128 (28%)
BET 951..1015 CDD:293640 14/68 (21%)
BRD4_CDT <2026..2046 CDD:293710
ep300aXP_009304968.1 zf-TAZ 362..429 CDD:280324
Med15 439..>907 CDD:255446 84/434 (19%)
KIX 571..649 CDD:280354 12/78 (15%)
Bromo_cbp_like 1056..1163 CDD:99927 36/108 (33%)
RING_CBP-p300 1175..1266 CDD:276805 13/94 (14%)
PHD_p300 1267..1301 CDD:277116 2/33 (6%)
HAT_KAT11 1330..1637 CDD:285432 51/330 (15%)
ZZ_CBP 1693..1733 CDD:239077 5/39 (13%)
ZnF_TAZ 1754..1832 CDD:214717 10/77 (13%)
Creb_binding 2141..2246 CDD:286163 33/110 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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