DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fs(1)h and Cecr2

DIOPT Version :9

Sequence 1:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster
Sequence 2:	XP_008761473.1	Gene:	Cecr2 / 500308	RGDID:	1564182	Length:	1465	Species:	Rattus norvegicus

Alignment Length:	780	Identity:	164/780 - (21%)
Similarity:	256/780 - (32%)	Gaps:	255/780 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IVQPPVIPP---------AERPGRNTNQLQYL------IKTVMKVIWKHHFSWPFQQPVDAKKLN 69
            :.|...:||         ..|.|:.|..:..|      :..|:.|:..|..||||.:|||  :..
  Rat   385 LAQGKELPPELSHLDLNSPMREGKKTKDIFELDDDFTAMYKVLDVVKAHKDSWPFLEPVD--ESY 447

  Fly    70 LPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFL 134
            .|:|::|||.|||:.:::|:|....|.:.:|.:.|..|||.||..||....:...|::.||:.|.
  Rat   448 APNYYQIIKIPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGDSSEYTKMSENLERCFH 512

  Fly   135 QKI-ESMPKEELELEP-----VTAKGGKKKQRAPAT-------------------PKSSSGG--- 171
            :.: :..|.|:.:.:.     ...|..|::.||..:                   |...:||
  Rat   513 RAMTKHFPGEDGDTDEEFWIREDEKREKRRSRAGRSSGSHVWTRSRDTEGSSRKQPPMENGGKSL 577

  Fly   172 ----AGASTGSGTSSAAVTSGPGSGSTK-------------VSVA--------ASSAQQSGLQGA 211
                ..||:|...||:::...|..|::.             .|.|        |:|.....|||:
  Rat   578 PPARRAASSGDDQSSSSIQLPPEVGTSNGRGFFHPLHYSRVPSQAPPLNQMRPAASGTFGSLQGS 642

  Fly   212 TGAG-GGSSSTPGTQPG----------------SGAGGAIAARP----------VSAMG------ 243
            .... .|||..|...||                |...|:..:.|          :|.||
  Rat   643 DPTNLHGSSRIPEVPPGEPLQHPPFAIQAPVGISNHRGSRLSAPEEKMCGGLTHLSNMGSHVPSL 707

  Fly   244 ----------------------GTVSSTAGGAPSIPP----ISTMPPHTV--------------- 267
                                  |.:.|..||.|:.||    .|.:||..:
  Rat   708 QLGQMNCNSQDGNIYPPAPFQAGFIPSRHGGTPARPPDFPESSEIPPSHIYHSYKYLNRVHPAVW 772

  Fly   268 PGSTNTTTTAMAG----GVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVNSSSLLDGS 328
            .|:..||.....|    .:.||||: .:|:|...|..    |:....|..|.|....||.|..|.
  Rat   773 NGNHGTTNPGRLGPDEKPLVGPGAS-HHPHALGHMMD----GRVMRQPIPPNQWTKQSSFLPPGV 832

  Fly   329 TAAVAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGV----DAVIPPQ 389
            .::........:|..........|.......|:.|:..|...::.:::...:.:    ..|.||.
  Rat   833 PSSGYMQPPCKSAGHRLQPPPTPAPSPRFRGPSQALRGAQGGESMMDSPEMIAMQQLSSRVCPPG 897

  Fly   390 QPAKIKKGVKRKADTTTPTANAFESPYTQMDSKSAKIATRRESNRQVIGKKGSGYNMS----PLG 450
            .|...::          ||......|:.|: :.||.:..  .:.:..:...||...:|    |.|
  Rat   898 VPYHPRQ----------PTPPQLPGPFPQV-AHSASVCV--SAPKPALDNPGSTQEISETQEPEG 949

  Fly   451 --VSGVPGLGGLVAGGVAGVAVAKNKEKLSDALKSCNEILKELFSKKHSGYAWPFYKPVDAEMLG 513
              ...||||                :||.:....|....||:|   .|..      .|:.|....
  Rat   950 DRAEPVPGL----------------EEKAASICSSEGLYLKQL---PHPA------PPLSASCTR 989

  Fly   514 LHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYN------PPDHD------- 565
            ....|:            |:.::.:.||....:||.       ||.:      |.|:.
  Rat   990 QSSPHE------------RETEDSQLKSDASDSADT-------YKASKNKNPWPLDNSYNSAAVQ 1035

  Fly   566 -VVAMGRKLQDVFEMRYANIPDEPVANAAHHHGHGHGHGHGHGHGHGHGHGHGHGHGYGGSSSLK 629
             .:..||.|..|.|.  .|:|:..|...|                   ......|.|.|||.|.|
  Rat  1036 GALHGGRDLAIVTER--GNLPENGVVGEA-------------------SPCRSEGKGLGGSGSEK 1079

Fly 630 629
Rat 1080 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	36/112 (32%)
		COG5076	387..>593	CDD:227408	45/225 (20%)
		Bromo_Brdt_II_like	481..581	CDD:99930	22/113 (19%)
		BET	951..1015	CDD:293640
		BRD4_CDT	<2026..2046	CDD:293710
Cecr2	XP_008761473.1	WHIM3	244..284	CDD:292248
Cecr2	XP_008761473.1	Bromo_gcn5_like	418..518	CDD:99941	34/101 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810