DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fs(1)h and Brd4

DIOPT Version :9

Sequence 1:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster
Sequence 2:	NP_001094373.1	Gene:	Brd4 / 362844	RGDID:	1307282	Length:	1403	Species:	Rattus norvegicus

Alignment Length:	2217	Identity:	570/2217 - (25%)
Similarity:	737/2217 - (33%)	Gaps:	1028/2217 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSSEPPPRYEPPVEPVNGIVQPPVIPPAERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAK 66
            |::.|||....|                .:|.|.|||||||::.|:|.:|||.|:|||||||||.
  Rat    42 STNPPPPETSNP----------------NKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAV 90

  Fly    67 KLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEK 131
            |||||||:||||.|||||||||||||||||:|:|.||||||||.|||:|||||:|:|:||:.|||
  Rat    91 KLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEK 155

  Fly   132 VFLQKIESMPKEELELEPVTAKG---GKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGSGS 193
            :|||||..:|.||.|:..|.|||   |:|:                   :||:...|::.|.:..
  Rat   156 LFLQKINELPTEETEIMIVQAKGRGRGRKE-------------------TGTAKPGVSTVPNTTQ 201

  Fly   194 TKVSVAASSAQQS---GLQGATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPS 255
            ...|......||:   .:|..|      ...|...|     ..||..||..|
  Rat   202 ASTSPQTQMPQQNPPPPVQATT------HPFPAVTP-----DLIAQPPVMTM------------- 242

  Fly   256 IPPISTMPPHTVPGSTNTTTTAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVN 320
            :||.....|..||                       |....              |.||....|.
  Rat   243 VPPQPLQTPSPVP-----------------------PQPPP--------------PPAPVPQPVQ 270

  Fly   321 SSSLLDGSTAAVAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAV 385
            |..                                    |.:|..
  Rat   271 SHP------------------------------------PIIATT-------------------- 279

  Fly   386 IPPQQPAKIKKGVKRKADTTTPTA--NAFESPYTQMDSKSAKIATRRESNRQVIGKK----GSGY 444
               .||.|.||||||||||||||.  ...|.|....:.|:||:..||||:|.|...|    .|..
  Rat   280 ---PQPVKTKKGVKRKADTTTPTTIDPIHEPPSLAPEPKTAKLGPRRESSRPVKPPKKDVPDSQQ 341

  Fly   445 NMSPLGVSGVPGLGGLVAGGVAGVAVAKNKEKLSDALKSCNEILKELFSKKHSGYAWPFYKPVDA 509
            :..|                       :...|:|:.||.|:.||||:|:|||:.||||||||||.
  Rat   342 HPGP-----------------------EKSSKISEQLKCCSGILKEMFAKKHAAYAWPFYKPVDV 383

  Fly   510 EMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQ 574
            |.||||||.||||.|||:.|:|.|:::|||:.|.||.|||||:|:||||||||||:||||.||||
  Rat   384 EALGLHDYCDIIKHPMDMSTIKSKLESREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQ 448

  Fly   575 DVFEMRYANIPDEP------------------VANAAHHHGHGHGHGHGHGHGHGHGHGHGHGHG 621
            ||||||:|.:||||                  ||..:
  Rat   449 DVFEMRFAKMPDEPEEPVVTVSSPAVPPPTKVVAPPS---------------------------- 485

  Fly   622 YGGSSSLKHDASDSSSEDSSDTENES-NSDEERSARLKMLESKLLGLQEEIRKLSEEASAK-KKA 684
                      :|||||:.|||:::.: :|:|||:.||..|:.:|..:.|::..||:....| ||.
  Rat   486 ----------SSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKK 540

  Fly   685 KKKLKEKKKSIGGGSGSGSASHHCHATGGGANAGGAGGPGSGGHGSVSVPGGVGSLGPGGAGGAN 749
            :|..|||||.
  Rat   541 EKDKKEKKKE------------------------------------------------------- 550

  Fly   750 LNALLGGSLVGHGGAAVAGGVPNVGALHSQVHDVAMAFSQMAGGGAAAGAGFGAGVTAAGASSGG 814
                                      .|.:..::.
  Rat   551 --------------------------KHKKKEEME------------------------------ 559

  Fly   815 KAGTLAGALAAGAAAGAGGTTAGSGSSKGAKSKGGRGAKGSGAGGVGASNNAAAGNAAGGAAGAA 879
                                     .:|.:|:|.....|..       .||::..|.
  Rat   560 -------------------------ENKKSKAKELPPKKTK-------KNNSSNSNV-------- 584

  Fly   880 AGAGSVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVGGANASAGGAGARGSSKKKPSQVM----- 939
                                                               |||:|:...
  Rat   585 ---------------------------------------------------SKKEPAPTKTKPPP 598

  Fly   940 NFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSLRDSNPDEIEIDFETLKPS 1004
            .::|||||..|||||:||||||||||||||:||||||||||:|||||::||||||||||||||||
  Rat   599 TYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPS 663

  Fly  1005 TLRELESYVASCLRKKTHKKPSGKSKDEQMAEKKQELEKRLQDVTGQLGASKKTAKKDESASSKV 1069
            ||||||.||.||||||  :||        .|||...:                      :.|||:
  Rat   664 TLRELERYVTSCLRKK--RKP--------QAEKVDVI----------------------AGSSKM 696

  Fly  1070 EAVQPANPVSSSSSSSDSSSSSSSDSSSSDSSDSEAVLV-------------------------- 1108
            :..            |.|.|.|:|:||||||.|||..:.
  Rat   697 KGF------------SSSESESTSESSSSDSEDSETEMAPKSKKKGHTGRDQKKHHHHHHPQMQP 749

  Fly  1109 IPAPTGDGDERPPRKKKSRDSNGSNVNNPSINVVMGGNLPSGALSPTTMLMGLDHVVNSNTP--- 1170
            .|||.......||::......       |..........|.....|.:|.......:.|:.|
  Rat   750 APAPVPQQPPPPPQQPPPPPP-------PQQQQQQQQQQPPPPPPPPSMPQQTAPAMKSSPPPFI 807

  Fly  1171 TSQMSNMLGNANPLTAAAMLNNNNKTSLPGSNFG----------GAPAPGNMMHAGAGVPVAGAA 1225
            |:|:..:                 :..||||.|.          ..|.|....|    :|.....
  Rat   808 TAQVPVL-----------------EPQLPGSVFDPIGHFTQPILHLPQPELPPH----LPQPPEH 851

  Fly  1226 VSASTGQQHNKNGPNDLSKV---QPGGPIN--AALPPHSFAGGTATVATSQSSGGIRIASNLHKP 1285
            .:.....||....|..|...   ||..|.|  |||||                          ||
  Rat   852 STPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPP--------------------------KP 890

  Fly  1286 SGLGGGDLGEHHAALAAALTSGINSTGTAGGGINNNGGSNNNANPLGGSHGDAMVNASLASLASG 1350
            :         ...|::.||                       |.|      ..:....:|
  Rat   891 A---------RPPAVSPAL-----------------------AQP------PLLPQPPMA----- 912

  Fly  1351 LKQIPQF----DDPVEQSLASLEFSAGSTGKSGLTDNFLMQQHLMQPAGP--------------- 1396
              |.||.    ::|....|.|::...           :|.|...:||..|
  Rat   913 --QPPQVLLEDEEPPAPPLTSMQMQL-----------YLQQLQKVQPPTPLLPSVKVQSQPPPPL 964

  Fly  1397 --------QQQQQQQQQQPFGHQQQQQQQQQQQQQQQQHMDYVTELLSKGAENVGGMNGNHLLNF 1453
                    ||||.|||..|....|.|...|||.|...:.:                    ||.
  Rat   965 PPPPHPSVQQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPV--------------------HLP-- 1007

  Fly  1454 NLDMAAAYQQKHPQQQQQQAHNNGFNVADFGMAGFDGLNMTAASFLDLEPSLQQQQMQQMQLQQ- 1517
            ::..:|..||..|...||..|.                          .|..|....|..:.||
  Rat  1008 SMPFSAHIQQPPPPTGQQPTHP--------------------------PPGQQPPPPQPAKPQQV 1046

  Fly  1518 -QHHQQQQQQTHQQQQQHQQQH----------H--QQQQQQQLTQQQLQQQQQQQQQQ------- 1562
             |||...:   |.:...:...|          |  |..|.|.||.|...||..|.::|
  Rat  1047 IQHHPSPR---HHKSDPYSAGHLREAPSPLMIHSPQMPQFQSLTHQSPPQQNVQPKKQVKGRAEP 1108

  Fly  1563 -------------------------QHLQQQQHQQQHHQAANKLLIIPKPI-------ESMMPSP 1595
                                     |.|:.....|.......|...|..||       .|:.|.|
  Rat  1109 QPPGPVMGRGQGCPPASPAAVPMLSQELRPPSVVQPQPLVVVKEEKIHSPIIRSEPFSTSLRPEP 1173

  Fly  1596 PDKQQLQQHQKVLP--PQQSPSDMK----LHPNAAAAAAVASAQAKLVQTFKA-----NEQNLKN 1649
            |...:..:....||  |:..|.|:.    ..|..:|....|..:.|..|..|.     .:..:||
  Rat  1174 PKHPENMKAPVHLPQRPEMKPVDVGRPVIRPPEQSAPPPGAPDKDKQKQEPKTPVAPKKDLKIKN 1238

  Fly  1650 ASSWSSLASANSPQSHTSSSSSSSKAKPAMDSFQQFRNKAKERDRLKLLEAAEKEKKNQKEAAEK 1714
            ..||:||.     |.|.::.||:  ||.:.|||:.||..|:|:      |..||..|.|.|.|||
  Rat  1239 MGSWASLV-----QKHPTTPSST--AKSSSDSFEHFRRAAREK------EEREKALKAQAEHAEK 1290

  Fly  1715 EQQRKHHKSSSSSLTSAAVAQAAAIAAATAAAAVTLGAAAAAALASSASNPSGGSSSGGAGSTSQ 1779
            |::|...:...|.....|:.||.                                      ...:
  Rat  1291 EKERLRQERMRSREDEDALEQAR--------------------------------------RAHE 1317

  Fly  1780 QAITGDRDRDRDRERERERSGSGGGQSGNGNNSSNSANSNGPGSAGSGGSGGGGGSGPASAGGPN 1844
            :|   .|.:::.::::|:..
  Rat  1318 EA---RRRQEQQQQQQRQEQ--------------------------------------------- 1334

  Fly  1845 SGGGGTANSNSGGGGGGGGPALLNAGSNSNSGVGSGGAASSNSNSSVGGIVGSGGPGSNSQGSSG 1909

  Rat  1335 ----------------------------------------------------------------- 1334

  Fly  1910 GGGGGPASGGGMGSGAIDYGQQVAVLTQVAANAQAQHVAAAVAAQAILAASPLGAMESGRKSVHD 1974
                                ||           |.|..||||||    |::|
  Rat  1335 --------------------QQ-----------QQQQQAAAVAA----ASAP------------- 1351

  Fly  1975 AQPQISRVEDIKASPGGQGQSSPAQQSPQDRAAAKRAEQRRAEQERRRREALAGQIDMNMQSDLM 2039
                             |.|||    .||.....:|...|:.|||||||||:|..||||.||||:
  Rat  1352 -----------------QAQSS----QPQSMLDQQRELARKREQERRRREAMAATIDMNFQSDLL 1395

  Fly  2040 AAFEETL 2046
            :.|||.|
  Rat  1396 SIFEENL 1402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	81/105 (77%)
		COG5076	387..>593	CDD:227408	114/229 (50%)
		Bromo_Brdt_II_like	481..581	CDD:99930	73/99 (74%)
		BET	951..1015	CDD:293640	57/63 (90%)
		BRD4_CDT	<2026..2046	CDD:293710	12/19 (63%)
Brd4	NP_001094373.1	Bromo_Brdt_I_like	58..164	CDD:99929	81/105 (77%)
		Bromo_Brdt_II_like	354..455	CDD:99930	73/100 (73%)
		BET	610..674	CDD:293640	57/63 (90%)
		BRD4_CDT	1361..1403	CDD:293710	24/42 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I3986
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	673	1.000	Inparanoid score	I702
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100249
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X197
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.820