DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fs(1)h and tou

DIOPT Version :9

Sequence 1:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster
Sequence 2:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster

Alignment Length:	1553	Identity:	311/1553 - (20%)
Similarity:	471/1553 - (30%)	Gaps:	588/1553 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   693 KSIGGGSGSGSASHHCHATGGGANAGGAGGPGSGGHGSVSVPGGVGSLGPGGAGGANLNALLGGS 757
            |:.|.||...:::.:.:|.||    ||||||..        |.|:       ...|:|.|..|..
  Fly     3 KNAGDGSDGKNSNKNSNAGGG----GGAGGPHD--------PTGL-------LDAASLFAYWGRD 48

  Fly   758 LVGHGGAAVAGGVPNVGALHSQVHDVAMAFSQMAGGGAAAGAGFGAGVTAAGASSGGKAGTLAGA 822
            ..|...||.:..:.|               ||.   .|||.||.|....|.|||:..:.     :
  Fly    49 PTGAAAAAASNPLFN---------------SQF---NAAAAAGLGLLPQAGGASANDRY-----S 90

  Fly   823 LAAGAAAGAGG----TTAGSGSSKGAKSKGGRGAKGSGAGGVGASNNAAAGNAAG---------G 874
            :||.|||.||.    .|....:|:.|...|...|.......:.|.:..:...|:|         .
  Fly    91 MAAAAAAAAGAHHHQNTMAVAASQAASLAGLHPASWWSMAQLAAQDYFSRLQASGLSPFPHPDLA 155

  Fly   875 AAGAAAGAGSVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVGGANASAGGAGARGSSKKKPSQVM 939
            ||...||.|..||.|||||.||        |:...|.|||..|.:.:.||..:.|||..|.::
  Fly   156 AAFGPAGMGMGGGAGGAGAGGG--------GAGVLGQGGGGNGGSGNGGGGSSSGSSGSKSNK-- 210

  Fly   940 NFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSLRDSNPDEIEIDFETLKPS 1004
               |.:|..|......:::.|:..:|...........            :||           .:
  Fly   211 ---SRKEKRAAQQQQQQQQNLANSLNAAAAAAAAAAA------------NNP-----------AA 249

  Fly  1005 TLRELESYVASCLRKKTHKKPSGKSKDEQMAEKKQELEKRLQDVTGQLGASKKTAKKDESASSKV 1069
            .|..:..:.............:|...              :...:|..|:.|.||......|:..
  Fly   250 ALASMHGFGVGVPGTSIPSVSTGSGS--------------ISTNSGGHGSYKSTASAYGKPSTMT 300

  Fly  1070 EAVQPANP------------------VSSSSSSSDSSSSSSSDSSSSDSSDSEAVLVIPAPTGDG 1116
            .:....||                  |::::|.|.||.||...|....||.|
  Fly   301 SSSMANNPGSAYDPVTLHKELLAMQAVAAAASGSGSSGSSGKKSGGGGSSSS------------- 352

  Fly  1117 DERPPRKKKSRDSNGSNVNNPSINVVMGGNLPSGALSPTTMLMGLDHVVNSNTPTSQMSNMLGNA 1181
                     |..|.|..:..      .||.:.||               .::|..|..::.||..
  Fly   353 ---------SMHSLGMGIGG------SGGMMSSG---------------KASTSVSASNSSLGGM 387

  Fly  1182 NPLTAAAMLNNNNKTSLPGSNFGGAPAPGNMMHAGAGVPVAGAAVSASTGQQHNKNGP-----ND 1241
            :|             ||..||      |....|||.|      :.|:|:.:..:||.|     |.
  Fly   388 HP-------------SLTSSN------PLMSPHAGMG------SSSSSSSKDRDKNNPSLNALNS 427

  Fly  1242 LSK-----VQPGGPINAALPPHSFAGGTATVATSQSSGGIRIASNLHKPSGLGGGDLGEHHAALA 1301
            ||:     :.|...:.||:...:.:.|.:..||..||                     .||::..
  Fly   428 LSQFGALGMTPQQSMQAAMNAFAASTGVSPSATVTSS---------------------PHHSSQQ 471

  Fly  1302 AALTSGINSTGTAGGGINNNGGSNNNANPLG-GSHGDAMVNASLASLASGLKQIPQFDDPVEQSL 1365
            .....|.:||       :.:|.|::....:| ||...:::...|               |.:..:
  Fly   472 QQQMGGNSST-------SGSGKSSSKDYMMGTGSEHPSLLGVRL---------------PPDTEI 514

  Fly  1366 ASLEFSAGSTGKSGLTDNFLMQQHLMQPAGPQQQQQQQQQQPFGHQQQQQQQQQQQQQQQQHMDY 1430
              :::::...|                |..|....:.:::.....:||..||||:||.|.:
  Fly   515 --IKYTSSIVG----------------PKIPGTTSRGRKKTISETEQQTTQQQQKQQHQAE---- 557

  Fly  1431 VTELLSKGAENVGGMNGNHLLNFNLDMAAAYQQKHPQQQQQQAHNNGFNVADFGMAGFDGLNMTA 1495
                             .|||.              ||||.|...:....|...:..|.||:...
  Fly   558 -----------------QHLLQ--------------QQQQAQKELDSTKNAISSLLAFPGLSPAK 591

  Fly  1496 ASFLDLEPSLQQQQMQQMQLQQQHHQQQQQQTHQQQQQHQQQHHQQQQQQQLTQQQLQQQQQQQQ 1560
            .:.|::|                                           ........|||.||.
  Fly   592 RARLEME-------------------------------------------YAAMAAAAQQQHQQA 613

  Fly  1561 QQQHLQQQQHQQQHHQAANKLLIIPKPIESMMPSPPDKQQLQQHQKVLPPQQSPSDMKLHPNAAA 1625
            ||||..|||                                                 ||  ...
  Fly   614 QQQHQAQQQ-------------------------------------------------LH--GML 627

  Fly  1626 AAAVASAQAKLVQTFKANEQNLKNASSWSSLASANSPQSHTSSSSSSSKAKPAMDSFQQFRNKAK 1690
            .||.....|.|| .......|..:..|.|..:|:.:|.:.|||||:.|......:|
  Fly   628 GAAGIPGMAGLV-GLPGMSGNPLDQLSVSKASSSTAPTTSTSSSSAGSNLLNQSNS--------- 682

  Fly  1691 ERDRLKLLEAAEKEKKNQKEAAEKEQQRKHHKSSSSSLTSAAV----AQAAAIAAATAAAAVTLG 1751
              ||:::::.......|.......:.:..|..::..:..|..|    ...|..:|.|.:.||  |
  Fly   683 --DRVEVIKLPPTITSNGAYNLSSKGKEVHDLTTDMATNSGGVNLSLKSNAGSSALTPSGAV--G 743

  Fly  1752 AA----------AAAALASSASNPSGGSSSGGA--GSTSQQAITGDRDRDRDRERERERSGSGGG 1804
            :|          |...|:...|:.|..|||..|  ||:|..|...:...|        ...:..|
  Fly   744 SASNPITIDDFDAPLNLSMKPSDKSNSSSSNAAAGGSSSSSAALANLASD--------YQAASSG 800

  Fly  1805 QSGNG--NNSSNSANSNGPGSAGSGGSGGGGGSGPASAGGPNSGGGGTANSNSGGGGGGGGPALL 1867
            ||||.  :.||.:|...|.|....|...|.||:.||.||    .|.|.....||.||.|||.:..
  Fly   801 QSGNSLQSLSSITAALGGTGGMPGGSISGSGGTSPAPAG----AGSGATGGGSGSGGSGGGSSSY 861

  Fly  1868 NAGSNSNSGVG------------------------------------------------------ 1878
            ..|...|.|.|
  Fly   862 KEGRPRNLGRGVSKPKKNTVASLLAQSRAVGLKPMLATQQLLQQGADIEKIRLALSEANAHMETS 926

  Fly  1879 ---------SGGAASSNSNSSVGGIVGSGGP------------GSNSQGSSGG-------GGGGP 1915
                     ||.:.|.:.::::..:.....|            |...||...|       |...|
  Fly   927 TDSESVAAESGLSESESEDANILNVAELRVPLELGWKRETVIRGLTKQGQIRGEVTYYAPGSTTP 991

  Fly  1916 ASGGGMGSGAIDYGQQVAVLTQVAANAQAQHV---AAAVAAQAILAASPLGAMESGRKSVHDAQP 1977
            ....         ||..|:|.|..:|...::.   |.|:....:..|.|..|.:.....:.| :.
  Fly   992 LKSN---------GQVFAILEQQPSNLSRENFSFSARAIVGSFLQPAPPPYANDGEYIRMTD-ED 1046

  Fly  1978 QISRVEDIKA------------------------------------SPGGQGQSSPAQQSPQDR- 2005
            ...|:||:|.                                    ....|.::|..:|..:|:
  Fly  1047 VAKRLEDLKVFTRQTLNVEQRIEIAKQQQAMRDAKKLQKEELARNKEKARQEKNSKLEQQRKDKE 1111

  Fly  2006 --------AAAKRAEQ-----------RRAEQERRRREA-LAGQIDMNMQSDLMAAFE 2043
                    ...||.|:           ::.|:|:||:|| ||.:.::..|.:::.|.|
  Fly  1112 LKNQQAVEERKKRQEELDRLKQEELLKKQQEKEKRRQEAILAKEQELQKQKEMLLAAE 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929
		COG5076	387..>593	CDD:227408
		Bromo_Brdt_II_like	481..581	CDD:99930
		BET	951..1015	CDD:293640	5/63 (8%)
		BRD4_CDT	<2026..2046	CDD:293710	5/18 (28%)
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691	15/82 (18%)
		ZapA	1021..1127	CDD:294720	14/106 (13%)
		MAP7	1043..1198	CDD:283355	23/128 (18%)
		RILP-like	1085..>1179	CDD:304877	18/85 (21%)
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248
		PHD_BAZ2A_like	2640..2685	CDD:277020
		RanBP2-type Zn finger	2640..2659	CDD:275375
		RanBP2-type Zn finger	2680..2698	CDD:275376
		PHD	2695..2744	CDD:279022
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900