DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fs(1)h and Cecr2

DIOPT Version :9

Sequence 1:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster
Sequence 2:	NP_001355635.1	Gene:	Cecr2 / 330409	MGIID:	1923799	Length:	1453	Species:	Mus musculus

Alignment Length:	630	Identity:	132/630 - (20%)
Similarity:	210/630 - (33%)	Gaps:	205/630 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IVQPPVIPP---------AERPGRNTNQLQYL------IKTVMKVIWKHHFSWPFQQPVDAKKLN 69
            :.|...:||         ..|.|:.|..|..|      :..|:.|:..|..||||.:|||  :..
Mouse   385 LAQGKELPPELSHLDLNSPMREGKKTKDLFELDDDFTAMYKVLDVVKAHKDSWPFLEPVD--ESY 447

  Fly    70 LPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFL 134
            .|:|::|||.|||:.:::|:|....|.:.:|.:.|..|||.||..||....:...|:..||:.|.
Mouse   448 APNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMSDNLERCFH 512

  Fly   135 QKI-------------ESMPKEELELEPVTAKGGK-----------------KKQRAPATPKSSS 169
            :.:             |...||:.:.|...::.|:                 :||     |...:
Mouse   513 RAMTKHFPGEDGDTDEEFWIKEDEKREKRRSRSGRSSGSHVWTRSRDTEGSSRKQ-----PPVEN 572

  Fly   170 GG-------AGASTGSGTSSAAVTSGPGSGST------------KVSVAASSAQQ---------S 206
            ||       ..||:|...|.:::...|..|::            :|...|....|         .
Mouse   573 GGKSLPPARRAASSGDDQSRSSIQLPPEVGTSHGQGFSRPLHCGRVPSHAPPLNQMRPAAPGTFG 637

  Fly   207 GLQGATGAG-GGSSSTPGTQPG-----------------SGAGGAIAARPVSAMG---------- 243
            .|||:.... .|||..|...||                 :..|..::|..:|.||
Mouse   638 SLQGSDPTNLHGSSRIPEAPPGEPLQHPPFAIQAPVGISNHRGSLLSAPDLSNMGSHVPSLQLGQ 702

  Fly   244 ------------------GTVSSTAGGAPSIPP----ISTMPP-------------HTVPGSTNT 273
                              |.:.|..||.|:.||    .|.:||             |....:.|.
Mouse   703 MNCPSQDGNMYPPAPFQAGFIPSRHGGTPARPPDFPESSEIPPGHIYHSYKYLNRAHPAVWNGNH 767

  Fly   274 TTTAMAGGVG-------GPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVNSSSLLDGSTAA 331
            .|| ..|.:|       |||.: .:|:....|..    |:....|..|.|....||.|..|..::
Mouse   768 GTT-NPGRLGPDEKPHLGPGPS-HHPHTLGHMMD----GRVMRQPIPPNQWTKQSSFLPHGVPSS 826

  Fly   332 VAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGV----DAVIPPQQPA 392
            ........:|..........|.......|:.|:..|...::.:::...:.:    ..|.||..|.
Mouse   827 GYMQPPCKSAGHRLQPPPTPAPSPRFRGPSQALRGAQGGESMMDSPEMIAMQQLSSRVCPPGVPY 891

  Fly   393 KIKKGVKRKADTTTPTANAFESPYTQMDSKSAKIATRRESNRQVIGKKGSGYNMS---------- 447
            ..::          ||......|:.|: :.||.:..  .:.:..:...||...|:
Mouse   892 HPRQ----------PTPPQLPGPFPQV-AHSASVCV--SAPKPALDNPGSTQEMTETHEPEEDPA 943

  Fly   448 -PLGVSGVPGLGGLVAGGVAGVAVAKNKEKLSDALKSCNEILKEL 491
             ||     ||                ::||.:....|....||:|
Mouse   944 EPL-----PG----------------HEEKAASICSSEGVYLKQL 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	38/124 (31%)
		COG5076	387..>593	CDD:227408	22/116 (19%)
		Bromo_Brdt_II_like	481..581	CDD:99930	4/11 (36%)
		BET	951..1015	CDD:293640
		BRD4_CDT	<2026..2046	CDD:293710
Cecr2	NP_001355635.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..237
		Bromo_gcn5_like	418..518	CDD:99941	34/101 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..667		25/135 (19%)
		PHA03247	<558..1031	CDD:223021	85/455 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..796		8/30 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	827..868		5/40 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	884..1020		23/118 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1072
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1131..1308
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1331..1368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1396..1453
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810