DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fs(1)h and brd3b

DIOPT Version :9

Sequence 1:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster
Sequence 2:	XP_005165650.2	Gene:	brd3b / 327108	ZFINID:	ZDB-GENE-030131-5316	Length:	730	Species:	Danio rerio

Alignment Length:	1149	Identity:	408/1149 - (35%)
Similarity:	493/1149 - (42%)	Gaps:	464/1149 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSSEPPPRYEPPVEPVNGIVQPPVIPP----AERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQ 61
            ||:...|.:...|      ||.||  ||    :.:|||.||||||:...|:|.:|||.|:|||..
Zfish     1 MSAVTSPAQVPAP------IVNPP--PPEFINSGKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYT 57

  Fly    62 PVDAKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMA 126
            ||||.|||||||||:||.|||||||||||||||||:|.|.:|||||||.|||:||||.:|:|:||
Zfish    58 PVDAIKLNLPDYHKVIKNPMDMGTIKKRLENNYYWTAGECMQDFNTMFTNCYIYNKPTDDIVLMA 122

  Fly   127 QTLEKVFLQKIESMPKEELELEPVTAKGGKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGS 191
            |.|||:||||:..||:||:||.|...||   |.|.|..|                       |||
Zfish   123 QALEKIFLQKVAQMPQEEVELLPPPPKG---KARKPGAP-----------------------PGS 161

  Fly   192 GSTKVSVAASSAQQSGLQGATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPSI 256
            .:          |||   .|...|..|||.|.:.|.......|||.||:    |:::....||
Zfish   162 EN----------QQS---IALTPGSPSSSCPSSPPQLAQTPVIAATPVA----TITTNVQAAP-- 207

  Fly   257 PPISTMPPHTVPGSTNTTTTAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVNS 321

Zfish   208 ----------------------------------------------------------------- 207

  Fly   322 SSLLDGSTAAVAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAVI 386
                                                  ||.                     |:|
Zfish   208 --------------------------------------PAT---------------------AMI 213

  Fly   387 PPQQPAKIKKGVKRKADTTTP-----TANAFESPYTQMDSKSAKIATRRESNRQVIGKKGSGYNM 446
            |..||...|||||||||||||     ||:..|||...::||.:|:.:||||..:.|
Zfish   214 PTAQPVVKKKGVKRKADTTTPTTCAITASRSESPTAMLESKHSKVISRRESTGRPI--------- 269

  Fly   447 SPLGVSGVPGLGGLVAGGVAGVAVAKNKEKLSDALKSCNEILKELFSKKHSGYAWPFYKPVDAEM 511
                   .|....|..|.|.  .....|.||:|.||.|:.||||:.||||:.||||||||||||.
Zfish   270 -------KPPKKDLEDGDVQ--QPGNKKSKLNDHLKYCDTILKEMLSKKHAAYAWPFYKPVDAEA 325

  Fly   512 LGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDV 576
            |.|||||:|||:||||.|||:|||:|||..|..|||||||:|:||||||||||:||||.||||||
Zfish   326 LELHDYHEIIKQPMDLSTVKKKMDSREYPDAQNFAADVRLMFSNCYKYNPPDHEVVAMARKLQDV 390

  Fly   577 FEMRYANIPDEPV----ANAAHHHGHGHGHGHGHGHGHGHGHGHGHGHGYGGSSSLKHDASDSSS 637
            |||::|.:||||.    .||.                               |::.....|..||
Zfish   391 FEMKFAKMPDEPAEPSSPNAV-------------------------------SATAVVSKSTGSS 424

  Fly   638 EDSSD-TENESNSDEERSARLKMLES-----------------------KLLGLQEEIRKLSE-- 676
            |.|:| :.:.|:|:|||:.||..|:.                       :|..:.|::..||:
Zfish   425 ESSADSSSSSSDSEEERATRLAELQEQQFAVERPNGNRAGTKNGCAKRFQLKAVHEQLAALSQGP 489

  Fly   677 EASAKKKAKKKLKEKKKSIGGGSGSGSASHHCHATGGGANAGGAGGPGSGGHGSVSVPGGVGSLG 741
            .:..|||.:||.|||||
Zfish   490 VSKPKKKKEKKEKEKKK------------------------------------------------ 506

  Fly   742 PGGAGGANLNALLGGSLVGHGGAAVAGGVPNVGALHSQVHDVAMAFSQMAGGGAAAGAGFGAGVT 806

Zfish   507 ----------------------------------------------------------------- 506

  Fly   807 AAGASSGGKAGTLAGALAAGAAAGAGGTTAGSGSSKGAKSKGGRGAKGSGAGGVGASNNAAAGNA 871
                                                  |.|    .|......|.|..:..|.:.
Zfish   507 --------------------------------------KDK----EKDKDKNKVKAEEDKKAKST 529

  Fly   872 AGGAAGAAAGAGSVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVGGANASAGGAGARGSSKKKPS 936
            .                        .|.....|.:|:...........|..||         ||.
Zfish   530 Q------------------------PNKQTPQKKTSARKPNSTSTTRQAKKGG---------KPG 561

  Fly   937 QVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSLRDSNPDEIEIDFETL 1001
             ..|::|:||::. |||||||||||||||:|||:||||||||||:||||||||||||||||||||
Zfish   562 -AANYESDEEESL-PMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETL 624

  Fly  1002 KPSTLRELESYVASCLRKKTHK------KPSGKSKDEQMAEKKQELEKRLQDVTGQLGASKKTAK 1060
            |||||||||.||.|||:||..|      |.|.|||:|.:.|||:|||||||||:|||..:||..|
Zfish   625 KPSTLRELERYVKSCLQKKQRKPLPGTGKKSAKSKEELVQEKKKELEKRLQDVSGQLNNNKKPPK 689

  Fly  1061 KDESASSKVEAVQPANPVSSSSSSSDSSSSSSSDSSSSDSSDSE 1104
            |.|.|.|....  .|:.:|.|||||||.||||| .|||:||||:
Zfish   690 KAEKAGSAQGG--GASRLSGSSSSSDSGSSSSS-GSSSESSDSD 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	76/105 (72%)
		COG5076	387..>593	CDD:227408	120/214 (56%)
		Bromo_Brdt_II_like	481..581	CDD:99930	77/99 (78%)
		BET	951..1015	CDD:293640	59/63 (94%)
		BRD4_CDT	<2026..2046	CDD:293710
brd3b	XP_005165650.2	Bromo_Brdt_I_like	30..136	CDD:99929	76/105 (72%)
		Bromo_Brdt_II_like	294..395	CDD:99930	77/100 (77%)
		BET	574..638	CDD:293640	59/63 (94%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	152	1.000	Domainoid score	I4284
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	1	1.000	-	-		otm24226
orthoMCL	1	0.900	-	-		OOG6_100249
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X197
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.910