DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fs(1)h and bptf

DIOPT Version :9

Sequence 1:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster
Sequence 2:	XP_009297692.1	Gene:	bptf / 324479	ZFINID:	ZDB-GENE-030131-3200	Length:	2900	Species:	Danio rerio

Alignment Length:	1017	Identity:	202/1017 - (19%)
Similarity:	329/1017 - (32%)	Gaps:	364/1017 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   982 REPSLRDSNPD---------------EIEIDFETLKPSTLR-ELESYVASCLRKKTHKKPSGKSK 1030
            |..:||...|:               |.:::...::..|.| |.|...|:...|.:.:|.:.:.|
Zfish  1794 RSSALRPKKPEPAKQTGPVVIETWVAEEDLELWEIRAFTERVEREKAQAADPTKVSVQKKAEEVK 1858

  Fly  1031 DEQMAEKKQE----LEKRLQ------------------------------DVTGQLGASKK---T 1058
            .:..|:.||:    .:|||:                              .::||:.::.|   |
Zfish  1859 AQLEAQLKQQRLAAQQKRLEQQKPSTTSNTTTLTSTPTTPGTTTQKVVVGSISGQVTSTPKVVMT 1923

  Fly  1059 AKK------------DESASSKVEAVQPANPVSSSSSSSDSSSSSSSDSSSSDSSDSEAVLVIPA 1111
            .|.            .:|.:|.|:..|..|.||:||..:.::||:        ::..:...:..|
Zfish  1924 TKLGSPVTFQQNKNFQQSFASWVKQGQQGNSVSTSSVVTVAASSA--------TTSGQTFHIAAA 1980

  Fly  1112 PTGDGDERPPRKKKSRDSNGSNVNNPSINVVMGGNLPSGALSPTTMLMGLDHVVNSNTPTSQ--- 1173
            |                  ||...:     |:...||..|.|         .:|..|.||:|
Zfish  1981 P------------------GSMAGS-----VIAAKLPVPANS---------KIVTVNVPTTQGGL 2013

  Fly  1174 -----------MSNMLGNA------NPLTAAAMLNNNNKTSLPGSNFGGAPAPGNMMHAGAGV-- 1219
                       .|:..|||      .|.||...:..|..||..     .....|..:..|..|
Zfish  2014 VQVQQKVVGIIPSSTAGNAQSFPPFQPRTATINIRPNTTTSTQ-----QVLTTGTTLRPGMTVIR 2073

  Fly  1220 -PVAGAA---------------------VSASTGQQHNKNGPNDLSKVQPGGPINAALPPHSFAG 1262
             |:..|.                     |..|:|.|.....|...:..||..|...|.|......
Zfish  2074 SPLQQATTLGKTIIRTPLMVQQGQTQQQVQTSSGTQVVGTPPRLPTPNQPQTPQTPASPRPQQGQ 2138

  Fly  1263 GTATVA-----TSQSSGGIRIASNLHKPSGLGGGDL-----------GEHHAALAAALTSG---- 1307
            ...|:|     |..:.||.:..:.:.:..|...|.|           |.....:.||:.:|
Zfish  2139 VKLTLAQLTQLTQGAQGGNQGLTVVIQGQGQTTGQLQVIPQGVTVIPGPGQQLMQAAMPNGQVQR 2203

  Fly  1308 -----INSTGTAGGGINNNGGSNNNANPLG---GSHGDAMVNASLASLASGLKQIPQ-------- 1356
                 :....|......:...:.:|..|..   .:...|:.:.:.|.:.:..:..||
Zfish  2204 FLFTPMAPAPTPAPAPVSAPAAPSNTTPSSVPPAAAPTAVTSTTPAPIQTAARLAPQPQPPPSLP 2268

  Fly  1357 ------FDDPVEQSLASLEFSAGSTGKSGLTDNFLMQQHL--MQPAGPQQQQQQQQ--------- 1404
                  ...||:.:.|.::.:             ::.|..  :||..|.|.:.|.|
Zfish  2269 PPPSVPPSQPVQHTPAPIQTA-------------VIPQPTPPIQPHPPVQLRPQPQLPPQNPVVP 2320

  Fly  1405 QQPFGHQQQQQQQQQQQQQQ--------------QQHMDYVTELLSKGAENVGGMNGNHLLNFNL 1455
            ..|....|..|.......||              |..:....:|||     |.|:....|.:...
Zfish  2321 PTPVSTPQIAQVTATAPPQQITTLPVTQTTVTKVQPQIQLPPQLLS-----VPGLQQQVLSHIQS 2380

  Fly  1456 DMAAAYQQK------HPQQQQQQAHNNGFNVADFGMAGFDGLNMTAASFLDLEPSLQQQ---QMQ 1511
            .:||..|.:      .|||.:                            |.|...:|||   |:|
Zfish  2381 QVAAQIQAQVGTTAGMPQQIK----------------------------LQLPIQIQQQGGGQVQ 2417

  Fly  1512 QMQLQ----------QQHHQQQQQQTHQQQQQHQQQHHQQQQ-QQQLTQQQLQQQQQQQQQQ--- 1562
            ..|:|          |:..|:.||...||||:.:||..:::| ||.::|..|.|:|..|:|.
Zfish  2418 AHQIQNLVTIQTASVQEQLQRIQQLCEQQQQKKKQQEAKREQAQQHVSQSDLIQKQVAQKQNVAI 2482

  Fly  1563 QHLQQQQHQQQHHQAANKLLIIPKPIESMMPSPPDKQQLQQHQKVLPPQQSPSDMKLHPNAAAAA 1627
            :.|:|::......:..|:.:|:...:...:....||.: :|..|....::|....:...||:..:
Zfish  2483 EQLKQKKTMTPAEREENQRMIVCNQVMKFILDKIDKDE-RQAAKKRKREESVEQKRSKQNASKLS 2546

  Fly  1628 AVASAQAKLVQTFKANEQNLKNASSWSSLASANSPQSHTSSSSSSSKAKPAMDSFQQFR-NKAKE 1691
            |:         .||..|| ||                     :...|.:..:|...|.: .:..:
Zfish  2547 AL---------LFKHKEQ-LK---------------------ADILKKRALLDKELQLQVQEELK 2580

  Fly  1692 RDRLKLLEAAEKEKKNQKEAAEKEQQRKHHKSSSSSLTSAAVAQAAAIAAATAAAAVTLGAAAAA 1756
            ||.:||  ..||||                            |||||..||         |||||
Zfish  2581 RDLIKL--RREKEK----------------------------AQAAAAQAA---------AAAAA 2606

  Fly  1757 ALASSASNPSGGSSSGGAGSTSQQAITGDRDRDRDRERERER 1798
            |.|:|....||.||.  .|:.:....|..|.|:.:|:..:.:
Zfish  2607 AAAASTHVHSGLSSY--TGTVTSPTSTHKRKREEERDAAKPK 2646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929
		COG5076	387..>593	CDD:227408
		Bromo_Brdt_II_like	481..581	CDD:99930
		BET	951..1015	CDD:293640	9/48 (19%)
		BRD4_CDT	<2026..2046	CDD:293710
bptf	XP_009297692.1	DDT	198..254	CDD:280886
		WHIM1	296..345	CDD:292246
		PHD1_BPTF	349..391	CDD:277034
		WHIM2	414..439	CDD:292247
		PP28	<1833..1881	CDD:287254	13/47 (28%)
		PHD2_3_BPTF	2665..2711	CDD:277035
		PHD2_3_BPTF	2723..2769	CDD:277035
		Bromo_gcn5_like	2785..2885	CDD:99941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810