Protein Alignment fs(1)h and Brdt

DIOPT Version :10

• Sequence 1: NP_001259321.1
• Gene: fs(1)h / 31722
• FlyBaseID: FBgn0004656
• Length: 2046
• Species: Drosophila melanogaster
• Sequence 2: XP_063129088.1
• Gene: Brdt / 305123
• RGDID: 1306678
• Length: 952
• Species: Rattus norvegicus
• Alignment Length: 1483
• Identity: 415/1483 - (27%)
• Similarity: 544/1483 - (36%)
• Gaps: 635/1483 - (42%)

  Fly    20 IVQPPVIPP----AERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKKLNLPDYHKIIKQP 80
            ||.||  ||    |::.||.|||||:|.:.|:|.:|||.|||||||||||.||.||||:.||:.|
  Rat    10 IVNPP--PPEYINAKKTGRLTNQLQFLQRVVLKALWKHSFSWPFQQPVDAAKLKLPDYYTIIETP 72

  Fly    81 MDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQKIESMPKEEL 145
            ||:.||||||||.||..|.|.:.||||||:|||:|||||:|:|||||.|||:|:||:..||:||
  Rat    73 MDLSTIKKRLENRYYEKASECVGDFNTMFSNCYLYNKPGDDIVVMAQALEKLFMQKLSQMPQEE- 136

  Fly   146 ELEPVTAKGGKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGSGSTKVSVAASSAQQSGLQG 210
                 ...|||::.:.....|:                               |.|||::.
  Rat   137 -----QIVGGKERMKKDIQQKT-------------------------------AVSSAKEQ---- 161

  Fly   211 ATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPSIPPISTMPPHTVPGSTNTTT 275
                          .|...|......:.:.|          |.|.:
  Rat   162 --------------TPSKSAENVFKRQEIPA----------GFPDV------------------- 183

  Fly   276 TAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVNSSSLLDGSTAAVAAAAAAAA 340
                                  ..|.||..|. |.|....||.|
  Rat   184 ----------------------CLSPLNMAQE-APPTCDSQTVV--------------------- 204

  Fly   341 AAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAVIPPQQPAKIKKGVKRKADTT 405
                                                                :|.|||||:||||
  Rat   205 ----------------------------------------------------QITKGVKRRADTT 217

  Fly   406 TPTAN----AFESPYTQMDSKSAKIATRRESNRQVIGKKGSGYNMSPLGVSGVPGLGGLVAGGVA 466
            |||.:    :.|||....::|.|....:..:.:.|:......:.
  Rat   218 TPTTSSAKASSESPPPLREAKPANAPVKENTVKSVLPDSQQQHR--------------------- 261

  Fly   467 GVAVAKNKEKLSDALKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVK 531
               |.|. .|:::.||.|:|||||:.:|||..||||||.|||.:.||||:|:||:|.||||||:|
  Rat   262 ---VLKT-VKVTEQLKHCSEILKEMLAKKHLPYAWPFYNPVDVDALGLHNYYDIVKNPMDLGTIK 322

  Fly   532 RKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDVFEMRYANIPDEPVAN--AAH 594
            .|||.:|||.|.||||||||:|.||||||||||:||.|.|.|||||||.:|.||||||.:  |.|
  Rat   323 GKMDKQEYKDACEFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFEMHFAKIPDEPVESMRACH 387

  Fly   595 HHGHGHGHGHGHGHGHGHGHGHGHGHGYGGSSSLKHDASDSSSEDSSDTENESNSDEERSARLKM 659
            .                            .::|.|..:.:||||.||...:..:|::||..||..
  Rat   388 L----------------------------TTNSAKALSRESSSEASSGDCSSEDSEDERVQRLAK 424

  Fly   660 LESKLLGLQEEIRKLSE---EASAKKKAKKKLKEKKKSIGGGSGSGSASHHCHATGGGANAGGAG 721
            |:.:|..:.::::.||:   ....||..|.|...|:|.:....
  Rat   425 LQEQLNAVHQQLQVLSQVPLRKLKKKNEKSKRAPKRKKVNRDE---------------------- 467

  Fly   722 GPGSGGHGSVSVPGGVGSLGPGGAGGANLNALLGGSLVGHGGAAVAGGVPNVGALHSQVHDVAMA 786
                                                                             
  Rat   468 ----------------------------------------------------------------- 467

  Fly   787 FSQMAGGGAAAGAGFGAGVTAAGASSGGKAGTLAGALAAGAAAGAGGTTAGSGSSKGAKSKGGRG 851
                                                                             
  Rat   468 ----------------------------------------------------------------- 467

  Fly   852 AKGSGAGGVGASNNAAAGNAAGGAAGAAAGAGSVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVG 916
                                                          |..|:||.......
  Rat   468 ----------------------------------------------NPKKKAKQMKQKEK----- 481

  Fly   917 GANASAGGAGARGSSKKKPSQVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQN 981
                    |.:....||||...:    ||||.||||:|||||||||||||||||||||:|||||:
  Rat   482 --------AKSNQPKKKKPLLKL----EEEDNAKPMNYDEKRQLSLDINKLPGDKLGRIVHIIQS 534

  Fly   982 REPSLRDSNPDEIEIDFETLKPSTLRELESYVASCLRK---KTHKKPSGKSKDEQMAEKKQELEK 1043
            ||||||:||||||||||||||.|||||||.||.:||||   |.|.|...:||:|..:|||.|||:
  Rat   535 REPSLRNSNPDEIEIDFETLKASTLRELEKYVLACLRKRSLKPHAKKVVRSKEELHSEKKLELER 599

  Fly  1044 RLQDVTGQLGASKKTAKKDESASSKVEAVQPANP------------------------VSSSSSS 1084
            ||.||..||...|:..|:    .:|||.:.|..|                        .||||||
  Rat   600 RLLDVNNQLNCRKRQTKR----PAKVEKLPPPPPPPPELASGSRLSDSSSSSSSSGSGSSSSSSS 660

  Fly  1085 SDSSSSSSSDSSSSDSSDSEAVLVIPAPTGDGDERPPRKKKSRDSNGSNVNNPSINVVMGGNLPS 1149
            |..|.|||||||||||||||..:                            :|....|...:|||
  Rat   661 SSGSGSSSSDSSSSDSSDSEPEI----------------------------SPKFTGVKQNDLPS 697

  Fly  1150 GALSPTTMLMGLDHVVNSNTPTSQMSNMLGNANPLTAAAMLNNNNKTSLPGSNFGGAPAPGN--M 1212
                            ..||...|.|     ...:|:|       :|:|...:.|...|||.  .
  Rat   698 ----------------KENTKQIQCS-----VPDITSA-------ETALVQQSTGPCGAPGKPPQ 734

  Fly  1213 MHAGAGVPVAGAAVSASTGQQHNKNG----PNDLSKVQPGGP-INAALPPHSFAGGTATVATSQS 1272
            ...|..||....|..::...|.....    |.|..:|..|.| ::|:...|       ||...|.
  Rat   735 QMPGCQVPHHLQATESTASVQTQPLAEYVLPGDCKRVLHGPPVVHASAESH-------TVLELQC 792

  Fly  1273 SGGIRIASNLHKPSGLGGGDLGEHHAALAAALTSGINSTGTAGGGINNNGGSNNNANPLGGS--- 1334
                                    ||.:...:.            |.|.....:...|:..|
  Rat   793 ------------------------HAPVQKDIK------------IKNADSWKSLGKPVKASSVL 821

  Fly  1335 -HGDAMVNA-SLASLASGLKQIPQ----------FDDPVEQSLASLEFSAGSTGKSGLTDNFLMQ 1387
             ..|.:.|. ..|::...:|...|          ..||.....:..||.:|.|.:|        .
  Rat   822 KSSDELFNQFRKAAIEKEVKARTQEQIRKHLEHSAKDPKVSQESQREFGSGFTPES--------S 878

  Fly  1388 QHLMQPAGPQQQQQQQQQQPFGHQQQQ------------QQQQQQQQQQQQHM 1428
            .:.:|.....::|.:|||.|...:.|.            .::::|::::::.|
  Rat   879 SNKVQGRSHGEEQSEQQQLPSPSETQDISKLWLLKDRNLAREKEQERRRREAM 931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	72/105 (69%)
		COG5076	387..>593	CDD:227408	101/211 (48%)
		Bromo_Brdt_II_like	481..581	CDD:99930	72/99 (73%)
		BET	951..1015	CDD:435704	57/63 (90%)
		BRD4_CDT	<2026..2046	CDD:465349
Brdt	XP_063129088.1	None