DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fs(1)h and Brdt

DIOPT Version :9

Sequence 1:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster
Sequence 2:	NP_001012031.1	Gene:	Brdt / 305123	RGDID:	1306678	Length:	326	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	163/520 - (31%)
Similarity:	212/520 - (40%)	Gaps:	215/520 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IVQPPVIPP----AERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKKLNLPDYHKIIKQP 80
            ||.||  ||    |::.||.|||||:|.:.|:|.:|||.|||||||||||.||.||||:.||:.|
  Rat    10 IVNPP--PPEYINAKKTGRLTNQLQFLQRVVLKALWKHSFSWPFQQPVDAAKLKLPDYYTIIETP 72

  Fly    81 MDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQKIESMPKEEL 145
            ||:.||||||||.||..|.|.:.||||||:|||:|||||:|:|||||.|||:|:||:..||:||
  Rat    73 MDLSTIKKRLENRYYEKASECVGDFNTMFSNCYLYNKPGDDIVVMAQALEKLFMQKLSQMPQEE- 136

  Fly   146 ELEPVTAKGGKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGSGSTKVSVAASSAQQSGLQG 210
                 ...|||::.:.....|:                               |.|||::.
  Rat   137 -----QIVGGKERMKKDIQQKT-------------------------------AVSSAKEQ---- 161

  Fly   211 ATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPSIPPISTMPPHTVPGSTNTTT 275
                          .|...|......:.:.|          |.|.:
  Rat   162 --------------TPSKSAENVFKRQEIPA----------GFPDV------------------- 183

  Fly   276 TAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVNSSSLLDGSTAAVAAAAAAAA 340
                                  ..|.||..|. |.|....||.|
  Rat   184 ----------------------CLSPLNMAQE-APPTCDSQTVV--------------------- 204

  Fly   341 AAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAVIPPQQPAKIKKGVKRKADTT 405
                                                                :|.|||||:||||
  Rat   205 ----------------------------------------------------QITKGVKRRADTT 217

  Fly   406 TPTAN----AFESPYTQMDSKSAKIATRRESNRQVIGKKGSGYNMSPLGVSGVPGLGGLVAGGVA 466
            |||.:    :.|||....::|.|....:..:.:.|:......:.
  Rat   218 TPTTSSAKASSESPPPLREAKPANAPVKENTVKSVLPDSQQQHR--------------------- 261

  Fly   467 GVAVAKNKEKLSDALKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVK 531
               |.|. .|:::.||.|:|||||:.:|||..||||||.|||.:.||||:|:||:|.||||||:|
  Rat   262 ---VLKT-VKVTEQLKHCSEILKEMLAKKHLPYAWPFYNPVDVDALGLHNYYDIVKNPMDLGTIK 322

Fly 532 531
Rat 323 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	72/105 (69%)
		COG5076	387..>593	CDD:227408	57/149 (38%)
		Bromo_Brdt_II_like	481..581	CDD:99930	35/51 (69%)
		BET	951..1015	CDD:293640
		BRD4_CDT	<2026..2046	CDD:293710
Brdt	NP_001012031.1	Bromo_Brdt_I_like	26..132	CDD:99929	72/105 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..168		8/75 (11%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q58F21	208..219		9/10 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..257		17/47 (36%)
		Bromodomain	271..>322	CDD:295360	34/50 (68%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	1	1.000	-	-		otm45199
orthoMCL	1	0.900	-	-		OOG6_100249
Panther	1	1.100	-	-	O	PTHR22880
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X197
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.000