Protein Alignment fs(1)h and brd2a

DIOPT Version :10

• Sequence 1: NP_001259321.1
• Gene: fs(1)h / 31722
• FlyBaseID: FBgn0004656
• Length: 2046
• Species: Drosophila melanogaster
• Sequence 2: NP_571275.2
• Gene: brd2a / 30445
• ZFINID: ZDB-GENE-990415-248
• Length: 836
• Species: Danio rerio
• Alignment Length: 1176
• Identity: 406/1176 - (34%)
• Similarity: 512/1176 - (43%)
• Gaps: 466/1176 - (39%)

  Fly    10 YEPPVEP---VNGIVQPPVIPPAERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKKLNLP 71
            :|.|..|   .:|..||.|..|: |.||.|||||:|.|.::|.:|:|||:|||.:||||.|||||
Zfish    46 FEGPALPHIAQSGPPQPAVRDPS-RQGRMTNQLQFLQKALVKTLWRHHFAWPFHEPVDAAKLNLP 109

  Fly    72 DYHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQK 136
            ||:.||||||||||||||||||||.||.|.:|||||||.|||:||||.:|:|:|||:|||.||||
Zfish   110 DYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAFLQK 174

  Fly   137 IESMPKEELELEPVTAKGGKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGSGSTKVSVAAS 201
            :..||:.|.|:.....:|.:.|      ||.   |....:|..|::..|.            |.|
Zfish   175 VAQMPEVEEEIPAPVPRGKQSK------PKK---GQKLFSGGITTAHQVP------------AIS 218

  Fly   202 SAQQSGLQGATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPSIPPISTMPPHT 266
            |..|...         |..||.| |.|                 |.||             ||.|
Zfish   219 SLSQLAY---------SPPTPDT-PDS-----------------VLST-------------PPQT 243

  Fly   267 VPGSTNTTTTAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVNSSSLLDGSTAA 331
            :                                      .|..:|..|    ::|:..|.|
Zfish   244 L--------------------------------------ITKNFPPPP----LHSTPALLG---- 262

  Fly   332 VAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAVIPPQQPAKIKK 396
                                                                  :||.||...||
Zfish   263 ------------------------------------------------------LPPTQPTAKKK 273

  Fly   397 GVKRKADTTTPTANAF-----------------------------ESPYT----QMDSKSA---- 424
            ||||||||||||....                             :||.|    .||||.:
Zfish   274 GVKRKADTTTPTTTVMPLTLGVGGMGMGMGMGMSMGMGMGMGLGGDSPLTLSNMGMDSKQSLSLS 338

  Fly   425 -------KIATRRESNRQVIGKKGSGYNMSPLGVSGVPGLGGLVAGGVAGVAVAKNKE------K 476
                   |:..||         .|||..:.| ....:|.              ::|:.      |
Zfish   339 LGMSLEDKVPARR---------GGSGRPIKP-PRKDLPD--------------SQNQHQPVRRGK 379

  Fly   477 LSDALKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKS 541
            ||..|:.|:.|||||.||||:.||||||||||...||||||:|||..||||.|:|||||:|||:.
Zfish   380 LSQQLRYCSTILKELLSKKHTAYAWPFYKPVDVSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRD 444

  Fly   542 APEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDVFEMRYANIPDEPVANAAHHHGHGHGHGHGH 606
            |.:|||||||:|:|||||||||||||||.|:||||||.|:|.:||||:.:..
Zfish   445 ALQFAADVRLMFSNCYKYNPPDHDVVAMARRLQDVFEFRFAKMPDEPLESLP------------- 496

  Fly   607 GHGHGHGHGHGHGHGYGGSSSLKHDASDSSSED--SSDTENE----SNSDEERSARLKMLE---- 661
                    ....|.|.||.||....:|.||||.  ||::|:|    |:|:|||:.||..|:
Zfish   497 --------PASLGGGLGGDSSSSSSSSSSSSESDVSSESESESSPSSDSEEERAHRLAQLQEQVC 553

  Fly   662 SKLLGLQEEIRKLSEEASAKKKAKKKLKEKKKSIGGGSGSGSASHHCHATGGGANAGGAGGPGSG 726
            ::|..:.|::..||.....|.|.||:.|:|||       ......|..:.
Zfish   554 TQLRAVHEQLAALSSTPIIKPKKKKEKKDKKK-------KKKPEKHKRSR--------------- 596

  Fly   727 GHGSVSVPGGVGSLGPGGAGGANLNALLGGSLVGHGGAAVAGGVPNVGALHSQVHDVAMAFSQMA 791
                                          |::..........:|.:
Zfish   597 ------------------------------SVIEDEVVMRPAKIPKL------------------ 613

  Fly   792 GGGAAAGAGFGAGVTAAGASSGGKAGTLAGALAAGAAAGAGGTTAGSGSSKGAKSKGGRGAKGSG 856
                                                             .|..||:
Zfish   614 -------------------------------------------------PKTPKSR--------- 620

  Fly   857 AGGVGASNNAAAGNAAGGAAGAAAGAGSVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVGGANAS 921
                  ||:.||                              .|.::|.||:.       .:|.|
Zfish   621 ------SNSKAA------------------------------TSTQSKKSSNK-------KSNKS 642

  Fly   922 AGGAGARGSSKKKPS----------QVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVV 976
                  :.|.|.:|:          ...::|||||:...|||||||||||||||:|||:||||||
Zfish   643 ------KSSKKAQPTFFPPPLSHSGLTPHYDSEEEEETSPMSYDEKRQLSLDINRLPGEKLGRVV 701

  Fly   977 HIIQNREPSLRDSNPDEIEIDFETLKPSTLRELESYVASCLRKKTHKKP-------SGKSKDEQM 1034
            ||||:|||||||:||:||||||||||||||||||.||..|||||. :||       :|||::|..
Zfish   702 HIIQSREPSLRDTNPEEIEIDFETLKPSTLRELERYVMMCLRKKP-RKPFVAIKGSAGKSREELA 765

  Fly  1035 AEKKQELEKRLQDVTGQLGASKKTAKKDESASSKVEAVQPANPVSSSSSSSDSSSSSSSDSSSSD 1099
            .|||:|||:|||||:|||.:.||..|......|.||....|:.:|:||||||||||||| |||||
Zfish   766 LEKKRELERRLQDVSGQLNSVKKPQKTKAEKPSAVEPHAVASRLSASSSSSDSSSSSSS-SSSSD 829

  Fly  1100 SSDSEA 1105
            :|:|::
Zfish   830 TSESDS 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	76/105 (72%)
		COG5076	387..>593	CDD:227408	117/255 (46%)
		Bromo_Brdt_II_like	481..581	CDD:99930	74/99 (75%)
		BET	951..1015	CDD:435704	57/63 (90%)
		BRD4_CDT	<2026..2046	CDD:465349
brd2a	NP_571275.2	Bromo_Brdt_I_like	72..178	CDD:99929	76/105 (72%)
		Bromo_Brdt_II_like	383..484	CDD:99930	74/100 (74%)
		BET	676..740	CDD:435704	57/63 (90%)