Protein Alignment fs(1)h and BAZ2B

DIOPT Version :10

• Sequence 1: NP_001259321.1
• Gene: fs(1)h / 31722
• FlyBaseID: FBgn0004656
• Length: 2046
• Species: Drosophila melanogaster
• Sequence 2: XP_047299993.1
• Gene: BAZ2B / 29994
• HGNCID: 963
• Length: 2248
• Species: Homo sapiens
• Alignment Length: 1224
• Identity: 225/1224 - (18%)
• Similarity: 385/1224 - (31%)
• Gaps: 426/1224 - (34%)

  Fly   730 SVSVPGGVGSLGPGG--AGGANLNALLG--GSLVGHGG------AAVAGGVPNVGALHSQVHDVA 784
            |.|.|.....:..||  .|.|:|::.:.  |.|....|      :.|:...|.|.      |.|
Human    36 SSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPFNLSTVSSAFPMVS------HPV- 93

  Fly   785 MAFSQMAGGGAAAGAGFGAGVTAAGASSGGKAGTLA--GALAA----------------GAAAGA 831
                            ||....::|.|..|..|||.  .||||                .|....
Human    94 ----------------FGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTDAHTRT 142

  Fly   832 GGT---------------------------TAGSGSSKGAKSKGGRGA-KGSGAGGVGASNNAAA 868
            |.|                           |:|. |::....||..|: .||....|...|.:..
Human   143 GATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGK-SNRNGPEKGVNGSINGSNTSSVIGINTSVL 206

  Fly   869 GNAAGGAAGAAAGAGSVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVGGANASAGGAGARGSSKK 933
            ...|..:.|......|          ||||.....:.|.:......|...            ..|
Human   207 STTASSSMGQTKSTSS----------GGGNRKCNQEQSKNQPLDARVDKI------------KDK 249

  Fly   934 KPSQVMNFDSEEEDTAKPMSYDEKRQ--LSLDINKLPGDKLGRVVHIIQNREPSLRDSNPDEIEI 996
            ||.:.....|...|:....|.|...:  .|.|.:.|..|:        :..:.|:.:|..|:.:.
Human   250 KPRKKAMESSSNSDSDSGTSSDTSSEGISSSDSDDLEEDE--------EEEDQSIEESEDDDSDS 306

  Fly   997 DFETLKPSTLRELESYVASCLRKKTHKKPSGKSKDEQMAEKK----------------QELEKRL 1045
            :.|....|..:.|       |...:..|..|:...|:..||:                |..:|:.
Human   307 ESEAQHKSNNQVL-------LHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQP 364

  Fly  1046 QDVTGQLG-ASKKTAKKDESASSKVEAVQPANPVSS----------------------------- 1080
            |.::.||. ..:.:..|:||.:.....:|....||:
Human   365 QVLSQQLPFIFQSSQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAG 429

  Fly  1081 SSSSSDSSSSSSSDSSS---------------SDSSDS----EAVLVIPAPTGDGDERPPRKKKS 1126
            :.::|:.||..:|:..|               .:||.|    .|.|..|..|...   |...|::
Human   430 NKNTSEESSLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSS---PAHPKQT 491

  Fly  1127 RDSNGSNVNNPSI-NVVMGGNLPSGAL------SPTTMLMGLDHVVNSNTPTSQMSNMLGNANPL 1184
            .::|..   ||.: |.::|.:.|:|.:      :|..:          .|.|...|.:  |.| :
Human   492 LENNHP---NPFLTNALLGNHQPNGVIQSVIQEAPLAL----------TTKTKMQSKI--NEN-I 540

  Fly  1185 TAAAMLNNNNKTSLPGSNFGGAPAPGNMMHAGAGVPVAGAAVSASTGQQHNKNGPNDLSKVQP-- 1247
            .||:....::..:|..|   |...|||.      .||..:|......|...|...|:::.|:.
Human   541 AAASSTPFSSPVNLSTS---GRRTPGNQ------TPVMPSASPILHSQGKEKAVSNNVNPVKTQH 596

  Fly  1248 -GGPINAALPPHSFAGGTATVATSQ------------------------SSGGIRIASNLHKPSG 1287
             ..|..:.:  ..|.|..:.:.:|:                        .|...:..|:.:..|.
Human   597 HSHPAKSLV--EQFRGTDSDIPSSKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESD 659

  Fly  1288 LGGGD----------------LGEHHAALAAALTSGINSTGTAGGGINNNGGSNNNANPLGGSHG 1336
            ..|.:                .||..:......||.:.|...:..|  ::...|.:.....||..
Human   660 TEGSEEEDDDDKDQDESDSDTEGEKTSMKLNKTTSSVKSPSMSLTG--HSTPRNLHIAKAPGSAP 722

  Fly  1337 DAMVNASLASLASGLKQIPQFDDPVEQSLASLEFSAGSTGKSGLTDNFLMQQHLMQPA------- 1394
            .|:.:.|         |.|.|......:|.|...| |::.:..:||    ::.|..|.
Human   723 AALCSES---------QSPAFLGTSSSTLTSSPHS-GTSKRRRVTD----ERELRIPLEYGWQRE 773

  Fly  1395 ------GPQQQQQQQQQQPFGHQQQQQQQQQQQQQQQQHMDYVTELLSKGAE------------- 1440
                  |.:.|.:.....|.|.:.:|..:..:...:...||...:..|..|:
Human   774 TRIRNFGGRLQGEVAYYAPCGKKLRQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGP 838

  Fly  1441 ---------------NVGGMNGNHLLNFNLDMAAAYQQKHPQQQQQQAHNNGFNVADFGMAGFDG 1490
                           .:..|.|......|.|...|.::...::::.:..|.|
Human   839 QGMQWCLLKEEDVIPRIRAMEGRRGRPPNPDRQRAREESRMRRRKGRPPNVG------------- 890

  Fly  1491 LNMTAASFLD-----LEPSLQQQ----QMQQMQLQQQHHQQQQQQTHQQQQQHQ------QQHHQ 1540
                .|.|||     |...||.|    |..|::|.::..:|:|.:..::.::.|      ::..|
Human   891 ----NAEFLDNADAKLLRKLQAQEIARQAAQIKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQ 951

  Fly  1541 QQQQQQLTQQQLQQQQQQQQQQQHLQQQQ----HQQQHHQAAN-KLLIIPKPIESMMPSPPDKQQ 1600
            ::|.:.:.||:..::.||.:.::.|:.||    .:::..:||| |||...|.|:        :::
Human   952 KEQIKIMKQQEKIKRIQQIRMEKELRAQQILEAKKKKKEEAANAKLLEAEKRIK--------EKE 1008

  Fly  1601 LQQHQKVLPPQQSPSDMKLHPNAAAAAAVASAQAKLVQTFKANEQNLKNASSWSSLASANSPQSH 1665
            :::.|.||...|.....:.|                :...||.|.
Human  1009 MRRQQAVLLKHQERERRRQH----------------MMLMKAMEA-------------------- 1037

  Fly  1666 TSSSSSSSKAKPAMDSFQQFRNKAKERDRLKLLEAAEKEKKNQKEAAEKEQQRK 1719
                                |.||:|::|||  :....||:..||  .|.:||:
Human  1038 --------------------RKKAEEKERLK--QEKRDEKRLNKE--RKLEQRR 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929
		COG5076	387..>593	CDD:227408
		Bromo_Brdt_II_like	481..581	CDD:99930
		BET	951..1015	CDD:435704	12/65 (18%)
		BRD4_CDT	<2026..2046	CDD:465349
BAZ2B	XP_047299993.1	HAT_MBD	761..833	CDD:238691	11/71 (15%)
		DUF5401	<847..>1072	CDD:375164	60/306 (20%)
		DDT	1106..1168	CDD:214726
		WSD	1389..>1421	CDD:464775
		WSD	<1729..1768	CDD:464775
		PHD_BAZ2B	1984..2032	CDD:277100
		Bromo_BAZ2A_B_like	2117..2213	CDD:99935