DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fs(1)h and Brd2

DIOPT Version :9

Sequence 1:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster
Sequence 2:	NP_997660.1	Gene:	Brd2 / 294276	RGDID:	1303324	Length:	798	Species:	Rattus norvegicus

Alignment Length:	1154	Identity:	425/1154 - (36%)
Similarity:	523/1154 - (45%)	Gaps:	455/1154 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSEPPPRYEPPVEPVNGIVQPPVIPPAERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKK 67
            :|.|..:..|...|      ||.:...::|||.|||||||.|.|||.:|||.|:|||:|||||.|
  Rat    48 ASVPALQLAPANPP------PPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK 106

  Fly    68 LNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEKV 132
            |.||||||||||||||||||:||||||||:|.|.:|||||||.|||:||||.:|:|:|||||||:
  Rat   107 LGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKI 171

  Fly   133 FLQKIESMPKEELELEPVTAKGGKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGSGSTKVS 197
            ||||:.|||:||.||.....|...||              ||.
  Rat   172 FLQKVASMPQEEQELVVTIPKNSHKK--------------GAK---------------------- 200

  Fly   198 VAASSAQQSGLQGATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPSIPPISTM 262
                                                     ::|:.|:::|    |..:|.:|::
  Rat   201 -----------------------------------------LAALQGSITS----AHQVPAVSSV 220

  Fly   263 -------PPHTVPGSTNTTTTAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVN 320
                   ||..:|      ||.:  .:..|...     ::.|:.||.:||.
  Rat   221 SHTALYTPPPEIP------TTVL--NIPHPSVI-----SSPLLKSLHSAGP-------------- 258

  Fly   321 SSSLLDGSTAAVAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAV 385
                                                   |.:||:||
  Rat   259 ---------------------------------------PLLAVSAA------------------ 266

  Fly   386 IPPQQPAKIKKGVKRKADTTTPTANAF------ESPYTQMDSKSAKI-ATRRESNRQV------- 436
             ||.||...||||||||||||||..|.      .||...::.|:|:: ..||||.|.:
  Rat   267 -PPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDL 330

  Fly   437 --------IGKKGSGYNMSPLGVSGVPGLGGLVAGGVAGVAVAKNKEKLSDALKSCNEILKELFS 493
                    ..|||                                  |||:.||.||.|||||.|
  Rat   331 PDSQQQHQSSKKG----------------------------------KLSEQLKHCNGILKELLS 361

  Fly   494 KKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYK 558
            |||:.|||||||||||..|||||||||||.||||.||||||:||:|:.|.||||||||:|:||||
  Rat   362 KKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYK 426

  Fly   559 YNPPDHDVVAMGRKLQDVFEMRYANIPDEPV------ANAAHHHGHGHGHGHGHGHGHGHGHGHG 617
            |||||||||||.||||||||.|||.:||||:      .:.|...|....
  Rat   427 YNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTALPPGLAKS---------------- 475

  Fly   618 HGHGYGGSSSLKHDASDSSS-----EDSSDTENE---SNSDEERSARLKMLESKLLGLQEEIRKL 674
                 ...||.:..:|:|||     ||..|.|.|   |:|:|||:.||..|:.:|..:.|::..|
  Rat   476 -----SSESSSEESSSESSSEEEEEEDEEDEEEESESSDSEEERAHRLAELQEQLRAVHEQLAAL 535

  Fly   675 SEEASAKKKAKKKLKEKKKSIGGGSGSGSASHHCHATGGGANAGGAGGPGSGGHGSVSVPGGVGS 739
            |:...:|.|.|::.|||||       ...|..|....|...:..|...|
  Rat   536 SQGPISKPKRKREKKEKKK-------KRKAEKHRGRIGIDEDDKGPRAP---------------- 577

  Fly   740 LGPGGAGGANLNALLGGSLVGHGGAAVAGGVPNVGALHSQVHDVAMAFSQMAGGGAAAGAGFGAG 804
                                                     ..:....|:.||||
  Rat   578 -----------------------------------------RPLQPKKSKKAGGG---------- 591

  Fly   805 VTAAGASSGGKAGTLAGALAAGAAAGAGGTTAGSGSSKGAKSKGGRGAKGSGAGGVGASNNAAAG 869
                    |..|.||              :..|.|:|.|:.:|
  Rat   592 --------GSNATTL--------------SHPGFGTSAGSSNK---------------------- 612

  Fly   870 NAAGGAAGAAAGAGSVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVGGANASAGGAGARGSSKKK 934
                                         ..|:|:.::                          .
  Rat   613 -----------------------------LPKKAQKTA--------------------------P 622

  Fly   935 PSQVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSLRDSNPDEIEIDFE 999
            |.....:|||||:.::|||||||||||||||||||:||||||||||.||||||||||:|||||||
  Rat   623 PVLPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFE 687

  Fly  1000 TLKPSTLRELESYVASCLRKK-----THKKPSGKSKDEQMAEKKQELEKRLQDVTGQLGASKKTA 1059
            |||||||||||.||.||||||     |.:||.||:|:|...|||:|||||||||:|||.::||..
  Rat   688 TLKPSTLRELERYVLSCLRKKPRKPYTIRKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPP 752

  Fly  1060 KKDESASSKVE--AVQPA-NPVSSSSSSSDSSSSSSSDSSSSDSSDSEA 1105
            ||   ||.|.|  |.|.| :.:|:||||||||||||| |||||:|||::
  Rat   753 KK---ASEKTESSAQQVAVSRLSASSSSSDSSSSSSS-SSSSDTSDSDS 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	81/105 (77%)
		COG5076	387..>593	CDD:227408	122/233 (52%)
		Bromo_Brdt_II_like	481..581	CDD:99930	81/99 (82%)
		BET	951..1015	CDD:293640	59/63 (94%)
		BRD4_CDT	<2026..2046	CDD:293710
Brd2	NP_997660.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..72		4/24 (17%)
		Bromo_Brdt_I_like	73..179	CDD:99929	81/105 (77%)
		PHA03247	<215..332	CDD:223021	46/201 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..348		34/114 (30%)
		Bromo_Brdt_II_like	348..449	CDD:99930	81/100 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..648		70/386 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	553..557		2/10 (20%)
		BET	639..701	CDD:407211	57/61 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..798		43/67 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I3986
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	1	1.000	-	-		otm45199
orthoMCL	1	0.900	-	-		OOG6_100249
Panther	1	1.100	-	-	LDO	PTHR22880
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X197
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.910