Protein Alignment fs(1)h and BPTF

DIOPT Version :9

• Sequence 1: NP_001259321.1
• Gene: fs(1)h / 31722
• FlyBaseID: FBgn0004656
• Length: 2046
• Species: Drosophila melanogaster
• Sequence 2: XP_005257207.1
• Gene: BPTF / 2186
• HGNCID: 3581
• Length: 3158
• Species: Homo sapiens
• Alignment Length: 1062
• Identity: 213/1062 - (20%)
• Similarity: 338/1062 - (31%)
• Gaps: 361/1062 - (33%)

  Fly   987 RDSNPDEIEIDF------------ETLKPSTLRELESYVASCLRKKTHKKP-------------- 1025
            ||..|..|..::            ||.|.:...:.:...:|.||.|..:.|
Human  1951 RDVGPYGIRSEYCIRKIICPIGVPETPKETPTPQRKGLRSSALRPKRPETPKQTGPVIIETWVAE 2015

  Fly  1026 -----------SGKSKDEQMAEKKQELEKRLQDVTGQLGASKKTAKKDESASSKVEAVQPAN--- 1076
                       :.:.:.|:....:|:.:|||:.....:.|:..|:    ..||....:.||.
Human  2016 EELELWEIRAFAERVEKEKAQAVEQQAKKRLEQQKPTVIATSTTS----PTSSTTSTISPAQKVM 2076

  Fly  1077 --PVSSS------------------------------------SSSSDSSSSSSSDSSSSDSSDS 1103
              |:|.|                                    ...|:|::|:::.|:::.:|..
Human  2077 VAPISGSVTTGTKMVLTTKVGSPATVTFQQNKNFHQTFATWVKQGQSNSATSTAATSATTIASTG 2141

  Fly  1104 EAVLVIPAPTGDGDERPPRKKKSRDSNGSNVNN---PSINVVMGGNLPS---GALSPTTMLMGLD 1162
            :...:...|.              ...|..:..   |:.:.::..|:|:   |.:.....::|
Human  2142 QTFQITGNPV--------------TMAGKVITKLPLPANSKIVAVNVPATQGGVVQVQQKVLG-- 2190

  Fly  1163 HVVNSNTPTSQMSNMLGNANPLTAAAMLNNNN-------------------------KTSLPGSN 1202
             ::.|:|.|||.:  ..:..|.||...:..|.                         :|.|..|.
Human  2191 -IIPSSTGTSQQT--FTSFQPRTATVTIRPNTSGSGGTTSNSQVITGPQIRPGMTVIRTPLQQST 2252

  Fly  1203 FGGA----PAPGNMMHAGA----------GVPVAGAAVSA-----STGQQHNKNGPNDLSKVQPG 1248
            .|.|    |.   |:..||          |.||: .||||     ||..|.:.......|.:|.
Human  2253 LGKAIIRTPV---MVQPGAPQQVMTQIIRGQPVS-TAVSAPNTVSSTPGQKSLTSATSTSNIQS- 2312

  Fly  1249 GPINAALPPHSFAGGT-ATVA----TSQSSGGIRIASNLHKPSGLGGGDL-----------GEHH 1297
               :|:.||....|.. .|:|    .:|..||.:..:.:.:..|...|.|           |...
Human  2313 ---SASQPPRPQQGQVKLTMAQLTQLTQGHGGNQGLTVVIQGQGQTTGQLQLIPQGVTVLPGPGQ 2374

  Fly  1298 AALAAALTSG----------------------INSTGTAGGGINNNGGSNNNANPLGGSHGDAMV 1340
            ..:.||:.:|                      ..||..||.|...    .:..:|....|.|..:
Human  2375 QLMQAAMPNGTVQRFLFTPLATTATTASTTTTTVSTTAAGTGEQR----QSKLSPQMQVHQDKTL 2435

  Fly  1341 NASLASLASGLKQIPQFDDP--------VEQSLASLEFSAGSTGKSGLTDNFLMQQHLMQPAGPQ 1397
            ..:.:|.....:..||...|        ..||.|..|.......::..|    :..|:...|.|.
Human  2436 PPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTT----VSSHVPSEAQPT 2496

  Fly  1398 QQQQQQ-----QQQPFGHQQ--------------------------QQQQQQ------------- 1418
            ..|..:     |.||..:.|                          ||.|.|
Human  2497 HAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHT 2561

  Fly  1419 ------QQQQQQQQHMDYVTELLSKGAENVGGMNGNHLLNFNLDMAAAYQQKHPQQQQQQAHNNG 1477
                  |.|.|.|..:...|:.||.|.              .|:.........||.|.||.....
Human  2562 SLQIPSQGQPQSQPQVQSSTQTLSSGQ--------------TLNQVTVSSPSRPQLQIQQPQPQV 2612

  Fly  1478 FNVADFGMAGFDGLNMTAASFLDLEPSLQQQQMQQMQLQQQ---HHQQQQQQTHQQ--------- 1530
            ..|                      |.||||.....|:|.|   ..|.||....||
Human  2613 IAV----------------------PQLQQQVQVLSQIQSQVVAQIQAQQSGVPQQIKLQLPIQI 2655

  Fly  1531 QQQHQQQHHQQQQ----QQQLTQQQLQQQQQQQQQQQHLQQQQHQ-QQHH--QAANKLLIIPKPI 1588
            ||....|.||.|.    |....|:|||:.||.:.|||..:|||.: ::.|  ||:|:..||.|.:
Human  2656 QQSSAVQTHQIQNVVTVQAASVQEQLQRVQQLRDQQQKKKQQQIEIKREHTLQASNQSEIIQKQV 2720

  Fly  1589 ESMMPSPPDKQQLQQHQKVLPPQQSPSDMKLHPNAAAAAAVASAQAKLV--QTFKANEQNLKNAS 1651
              :|......:.|:|.:.:.|.::..:...:         |.:...|.:  :..|..:|..|...
Human  2721 --VMKHNAVIEHLKQKKSMTPAEREENQRMI---------VCNQVMKYILDKIDKEEKQAAKKRK 2774

  Fly  1652 SWSSLASANSPQSHTSSSSSSSKAKPAMDSFQQFRNK-AKER---DRLKLLEAAEKEKKNQKEAA 1712
            ...|:....|.|:.|..|:...|.|      :|.|.: .|:|   |:...:|..|:.|::.|...
Human  2775 REESVEQKRSKQNATKLSALLFKHK------EQLRAEILKKRALLDKDLQIEVQEELKRDLKIKK 2833

  Fly  1713 EKEQQRKHHKSSSSSLTSAAVAQAAAIAAATAAAAVTLGAAAAAALASSASNPSGGSSSGGAGST 1777
            ||:..:              :|||.|:||  ....||....|..|...|...|.....:|...:.
Human  2834 EKDLMQ--------------LAQATAVAA--PCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTP 2882

  Fly  1778 SQQAITGDRDRDRDRERERERS 1799
            :..|.:    :.|.||.|::.|
Human  2883 TLPAAS----QKRKREEEKDSS 2900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929
		COG5076	387..>593	CDD:227408
		Bromo_Brdt_II_like	481..581	CDD:99930
		BET	951..1015	CDD:293640	7/39 (18%)
		BRD4_CDT	<2026..2046	CDD:293710
BPTF	XP_005257207.1	DDT	241..297	CDD:280886
		WHIM1	339..388	CDD:292246
		PHD1_BPTF	392..434	CDD:277034
		Med15	2217..>2598	CDD:255446	76/410 (19%)
		TNG2	2742..2972	CDD:227367	42/194 (22%)
		PHD2_3_BPTF	2923..2969	CDD:277035
		PHD2_3_BPTF	2981..3027	CDD:277035
		Bromo_gcn5_like	3043..3143	CDD:99941

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810