back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fs(1)h and CREBBP

DIOPT Version :9

Sequence 1:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster
Sequence 2:	NP_004371.2	Gene:	CREBBP / 1387	HGNCID:	2348	Length:	2442	Species:	Homo sapiens

Alignment Length:	2203	Identity:	421/2203 - (19%)
Similarity:	632/2203 - (28%)	Gaps:	829/2203 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PVNGIV---QPP------VIP-------PAERPGRNTNQLQYL---------IKTVMKVIWKHHF 55
            |..||.   |||      .:|       |....|.|:..:..|         ..|.::..|..|.
Human   532 PAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHV 596

  Fly    56 S---------------WPFQQPV---DAKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETI 102
            :               :|...|.   |.:..||..|             .|::|.:.|.||....
Human   597 TQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAY-------------AKKVEGDMYESANSRD 648

  Fly   103 QDFNTMFNNCYVYNK------------------------PGEDVVVMAQTLEKVFLQKIE----- 138
            :.::.:....|...|                        ||....|:.|.      |.:.
Human   649 EYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQA------QPVRPPNGP 707

  Fly   139 -SMPKEELEL-------EPVTAKGGKKKQRAPATPKSSS--------GGAGASTGSGTSSAAVTS 187
             |:|...:::       .|::. |..:..:||..|:::|        ...|:..|...|.:.:..
Human   708 LSLPVNRMQVSQGMNSFNPMSL-GNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQ 771

  Fly   188 GPG--SGSTKVSVAASSAQ-----QSGLQGATGAGGGSSSTPGTQPGSGAG---GAIAARPVSAM 242
            .|.  ...|...:|.:.||     |:....::||.......|..|.|...|   ||....|::.:
Human   772 PPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNML 836

  Fly   243 GGTVS-------------------STAGGAPSI----PPISTMP-------PHTVPGSTNTTTTA 277
            |...|                   |||.|.||:    ||..|.|       |.|...|:..|.|.
Human   837 GPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTP 901

  Fly   278 MAGGVGGPGAAGANPNA-AALMASLLNAGQTGAYPGAPGQTAVNSSSLLDGSTAAVAAAAAAAAA 341
            ..|.|.......:.|.. ||..|.:....||   |..|...|...||....:...........:.
Human   902 TPGSVPSATQTQSTPTVQAAAQAQVTPQPQT---PVQPPSVATPQSSQQQPTPVHAQPPGTPLSQ 963

  Fly   342 AAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAVIPPQQPAKIKKGVKRKADTTT 406
            |||:....      ..|..:||....|:.|.              .|..|....|...:..||..
Human   964 AAASIDNR------VPTPSSVASAETNSQQP--------------GPDVPVLEMKTETQAEDTEP 1008

  Fly   407 PTANAFESPYTQMDSKSAKIATRRESNRQVIGKKGSGYNMSPLGV-SGVPGLGGLV-------AG 463
            ....:...|.::|..:..:.|::.:....:..:|.     .|:.| ...|.:...|       :.
Human  1009 DPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKS-----EPMEVDEKKPEVKVEVKEEEESSSN 1068

  Fly   464 GVAGVAVAKNK--------EKLSDALKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDYHDI 520
            |.|..:.:.::        |:|..||....|.|     .:....:.||.:|||.::||:.||.||
Human  1069 GTASQSTSPSQPRKKIFKPEELRQALMPTLEAL-----YRQDPESLPFRQPVDPQLLGIPDYFDI 1128

  Fly   521 IKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDVFEMRYANIP 585
            :|.||||.|:|||:|..:|:...::..||.|:|.|.:.||.....|.....||.:|||...
Human  1129 VKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEI---- 1189

  Fly   586 DEPVANAAHHHGHGHGHGHGHGHGHGHG------HG------------HGHGHGY---------- 622
             :||..:.         |:..|..:...      :|            :.:.:.|
Human  1190 -DPVMQSL---------GYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEI 1244

  Fly   623 -GGSSSLKHDASDSSSEDSSDTENESNSD------------------------------------ 650
             |.:.:|..|.|...:..|.|...:..:|
Human  1245 QGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCD 1309

  Fly   651 ----------EERSARLKMLESKLLG--LQEEIRKLSEE--------------ASAKKKAKKKLK 689
                      :|.....|.|::..||  |::.:.|....              ||:.|..:.|..
Human  1310 NCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPG 1374

  Fly   690 EKKKSIGGGSGSGSASHHCHATGGGANAGGAGGPGSGGH----GS-----------VSVPGGVGS 739
            .|.:.:..|..|.|..:...|........|......|.|    ||           :|....:..
Human  1375 MKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHF 1439

  Fly   740 LGPGGAGGANLNALLGGSL-----VGHGGAAVAGGVPNVG---ALHSQ----------------- 779
            ..|.....|..:.:|.|.|     :|:....:....|:.|   ..|..
Human  1440 FRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYK 1504

  Fly   780 -----------VHDVAMAFSQMAGGGAAAGAGFGAGVTAAGASSGGKAGTLAGALAAGA------ 827
                       :||....|.|               .|....:|..:.....|......
Human  1505 KMLDKAFAERIIHDYKDIFKQ---------------ATEDRLTSAKELPYFEGDFWPNVLEESIK 1554

  Fly   828 -------------AAGAGGTTAGS-GSSKGAKSKGGRGAKGSGAGGVGASNNAAAGNAAGGAAGA 878
                         :..|..||.|| |.||.||.|                ||..........:.|
Human  1555 ELEQEEEERKKEESTAASETTEGSQGDSKNAKKK----------------NNKKTNKNKSSISRA 1603

  Fly   879 AAGAGSVGGVGG-----------------------AGAA-------------------GGGNA-- 899
            .....|:..|..                       ||..                   .|.:|
Human  1604 NKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFL 1668

  Fly   900 ------------SKRAKGSS--------SAGAGGGVGGANASAGGAGAR---------------- 928
                        .:|:|.|:        :.|....|...|........|
Human  1669 TLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCY 1733

  Fly   929 ---GSSKKKPSQVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNRE-----PS 985
               ..:.|.....:..|.|.....:|.|...:....|.|.:.    :..:||..|.|.     ||
Human  1734 NTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRC----IQSLVHACQCRNANCSLPS 1794

  Fly   986 LRDSNPDEIEIDFETLKPSTLRELESYVASCLRKKT---------------HKKPSGKSK----- 1030
            .:                 .::.:..:...|.||..               |.|...::|
Human  1795 CQ-----------------KMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPF 1842

  Fly  1031 --DEQMAEKKQELEKRLQDVTGQL-----------GASKKTAKKDESASSKVEAVQPA------- 1075
              :.:...::|:::.|||.  .||           ...:::.....||.......||:
Human  1843 CLNIKHKLRQQQIQHRLQQ--AQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQP 1905

  Fly  1076 ------NPVSSSSSSSDSSSSSSSDSSSSDSSDSEAVLVIPAPTGDGDERPPRKKKSRDSNGS-- 1132
                  :|||.|.:...|.:.:...::.|....:..|   |||.......|...:.:|.....
Human  1906 PAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQV---PAPPPPAQPPPAAVEAARQIEREAQ 1967

  Fly  1133 --------NVNNPSINVVMGGNLPSGALSPTTMLMGLDHVVNSNTPTSQMSNMLGNA---NPLTA 1186
                    |:||         ::|.|...     ||        ||.|||:.:..|.   |.::.
Human  1968 QQQHLYRVNINN---------SMPPGRTG-----MG--------TPGSQMAPVSLNVPRPNQVSG 2010

  Fly  1187 AAMLNNNNKTSLPGSNFGGAPAPGNMMHAGAGVPV----AGAAV--------------------- 1226
            ..|      .|:|...:..||.|......|...||    |.|||
Human  2011 PVM------PSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQD 2069

  Fly  1227 ------SASTGQQHN------KNGPNDLSKV-----------QPGGPINAALPPHSFAGGTATVA 1268
                  |.|:.||..      |:.|..::..           |||......|
Human  2070 LLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGL------------- 2121

  Fly  1269 TSQSSGGIRIASNLH-KPSGLGGGDLGEHHAALAAALTSGINSTGTAGGGINNNGGSNNNANPLG 1332
              ||..|::....:| :||      |...:|..|.....|:.....|.||:|..|.:.|..||
Human  2122 --QSQPGMQPQPGMHQQPS------LQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNP-- 2176

  Fly  1333 GSHGDAMVNASLASLASGLKQIPQFDDPVEQSLASLEFSAGSTGKSGLTDNFLMQQHLMQPAGPQ 1397
             .|     |.::||:.      ||:.:                         ::::.|:|
Human  2177 -GH-----NPNMASMN------PQYRE-------------------------MLRRQLLQ----- 2199

  Fly  1398 QQQQQQQQQPFGHQQQQQQQQQQQQQQQQHMDYVTELLSKGAENVGGMNGNHLLNFNLDMAAAYQ 1462
                         ||||||||||||||||         ...|...|||.|
Human  2200 -------------QQQQQQQQQQQQQQQQ---------QGSAGMAGGMAG--------------- 2227

  Fly  1463 QKHPQQQQQQAHNNGFNVADFGMAGFDGLNMTAASFLDLEPSLQQQQMQQMQLQQQHHQQ----- 1522
              |.|.||.|           |..|:             .|::||||..|..|..|....
Human  2228 --HGQFQQPQ-----------GPGGY-------------PPAMQQQQRMQQHLPLQGSSMGQMAA 2266

  Fly  1523 QQQQTHQQQQQHQQQHHQQQQQQQLTQQQLQQQQQQQQ-----------QQQHLQQQQHQQQH-- 1574
            |..|..|..|...........||.|.|:.|||||.:||           .|||:...|.|..|
Human  2267 QMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLP 2331

  Fly  1575 -HQAANKL---LIIPKPIESMMP--SPPDKQQLQQHQKVLP---PQQSP---SDMKLHPNAAAAA 1627
             .|.|..|   :..|.|::|..|  .||       |....|   ||.||   |.....|:...|.
Human  2332 GQQIATSLSNQVRSPAPVQSPRPQSQPP-------HSSPSPRIQPQPSPHHVSPQTGSPHPGLAV 2389

  Fly  1628 AVASAQAKLVQTFKANEQNLKNASSWSSLASANSPQSHTSSSSSSSKAKPAMDSFQQF 1685
            .:||:         .::.:|.|....:.|...|:|.....||..|.......|:.::|
Human  2390 TMASS---------IDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEKF 2438

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.