DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fs(1)h and Crebbp

DIOPT Version :9

Sequence 1:NP_001259321.1 Gene:fs(1)h / 31722 FlyBaseID:FBgn0004656 Length:2046 Species:Drosophila melanogaster
Sequence 2:XP_006521814.1 Gene:Crebbp / 12914 MGIID:1098280 Length:2451 Species:Mus musculus


Alignment Length:2261 Identity:417/2261 - (18%)
Similarity:635/2261 - (28%) Gaps:901/2261 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SEPPPRYE----------PPVEPVNGIV---QPP------VIP-------PAERPGRNTNQLQYL 42
            ::||...:          |...|..||.   |||      .:|       |....|.|:..:..|
Mouse   509 AQPPAHQQMRTLNALGNNPMSIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGSL 573

  Fly    43 ---------IKTVMKVIWKHHFS---------------WPFQQPV---DAKKLNLPDYHKIIKQP 80
                     ..|.::..|..|.:               :|...|.   |.:..||..|       
Mouse   574 STIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAY------- 631

  Fly    81 MDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKP---------------GEDVVVMAQTLE 130
                  .|::|.:.|.||....:.::.:....|...|.               |....:.|...:
Mouse   632 ------AKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPASGAQ 690

  Fly   131 KVFLQKIESM--PKEELELEPVT--------------AKGGKKKQRAPATPKSSS--------GG 171
            ...:...:|:  |...|.| ||.              :.|..:..:||..|:::|        ..
Mouse   691 PPVIPPAQSVRPPNGPLPL-PVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNS 754

  Fly   172 AGASTGSGTSSAAVTSGP---GSGSTKVSVAASSAQQ----------SGLQGATGAGGGSSSTPG 223
            ..:..|...|.:.:...|   |:.:..:...|.:..|          ||.......|.|.   |.
Mouse   755 MASVPGMAISPSRMPQPPNMMGTHANNIMAQAPTQNQFLPQNQFPSSSGAMSVNSVGMGQ---PA 816

  Fly   224 TQPGSGAG---GAIAARPVSAMGGTVS-------------------STAGGAPSI---------P 257
            .|.|...|   ||....|::.:....|                   |||.|.||:         |
Mouse   817 AQAGVSQGQVPGAALPNPLNMLAPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHPTAPGMTP 881

  Fly   258 PISTMP--PHTVPGSTNTTTTAMAGGVGGPGAAGANPNA-AALMASLLNAGQTGAYPGAPGQTAV 319
            |....|  |.| |.|:..|.|...|.|.......:.|.. ||..|.:....||   |..|...|.
Mouse   882 PQPAAPTQPST-PVSSGQTPTPTPGSVPSAAQTQSTPTVQAAAQAQVTPQPQT---PVQPPSVAT 942

  Fly   320 NSSSLLDGSTAAVAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQ------AYVNAGV 378
            ..||....:...........:.|||:.....       ..|:...:|..:.|      ..:....
Mouse   943 PQSSQQQPTPVHTQPPGTPLSQAAASIDNRV-------PTPSSVTSAETSSQQPGPDVPMLEMKT 1000

  Fly   379 SVGVDAVIPPQQPAKIK---------------KGVKRKADTTTPTANAFESPYTQMDSKSAKIAT 428
            .|..|...|  :|.:.|               ..||.:.|||...:...|     ::.|..::..
Mouse  1001 EVQTDDAEP--EPTESKGEPRSEMMEEDLQGSSQVKEETDTTEQKSEPME-----VEEKKPEVKV 1058

  Fly   429 RRESNRQVIGKKGSGYNMSPLGVSGVPGLGGLVAGGVAGVAVAKNK----EKLSDALKSCNEILK 489
            ..:...:......:..:.||                    :..:.|    |:|..||....|.| 
Mouse  1059 EAKEEEENSSNDTASQSTSP--------------------SQPRKKIFKPEELRQALMPTLEAL- 1102

  Fly   490 ELFSKKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFT 554
                .:....:.||.:|||.::||:.||.||:|.||||.|:|||:|..:|:...::..||.|:|.
Mouse  1103 ----YRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFN 1163

  Fly   555 NCYKYNPPDHDVVAMGRKLQDVFEM-----------------------------RYANIPDEPVA 590
            |.:.||.....|.....||.:|||.                             :...||    .
Mouse  1164 NAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIP----R 1224

  Fly   591 NAAHHHGHGHGHGHGHGHGHGHGHGHGHGHGYGGSSSLKHDASDSSSEDSSDTENESNSD----- 650
            :||::........:|......|..........|.:.:|..|.|...:..|.|...:..:|     
Mouse  1225 DAAYYSYQNSSPKYGLLADRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPE 1289

  Fly   651 -----------------------------------------EERSARLKMLESKLLG--LQEEIR 672
                                                     :|.....|.|::..||  |::.:.
Mouse  1290 PFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVN 1354

  Fly   673 KLSEE--------------ASAKKKAKKKLKEKKKSIGGGSGSGSASHHCHATGGGANAGGAGGP 723
            |....              ||:.|..:.|...|.:.:..|..|.|..:...|........|....
Mouse  1355 KFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVC 1419

  Fly   724 GSGGH----GS-----------VSVPGGVGSLGPGGAGGANLNALLGGSL---------VGHGGA 764
            ..|.|    ||           :|....:....|.....|..:.:|.|.|         .||..|
Mouse  1420 FFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWA 1484

  Fly   765 AVAG--------------GVPNVGAL---HSQVHDVAMA----------FSQMAGGGAAAGAGFG 802
            ....              .:|....|   :.::.|.|.|          |.|....         
Mouse  1485 CPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIINDYKDIFKQANED--------- 1540

  Fly   803 AGVTAAGASSGGKAGTLAGALAAG--------------AAAGAGGTTAGS-GSSKGAKSKGGRGA 852
             .:|:|......:.......|...              .:..|..|..|| |.||.||.|     
Mouse  1541 -RLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETPEGSQGDSKNAKKK----- 1599

  Fly   853 KGSGAGGVGASNNAAAGNAAGGAAGAAAGAGSVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVGG 917
                                                         |..|..|..||      :..
Mouse  1600 ---------------------------------------------NNKKTNKNKSS------ISR 1613

  Fly   918 ANASAGGAGARGSSKKKPSQVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVVHI---- 978
            ||            |||||.            ..:|.|..::|...:.|  ..::..|:|:    
Mouse  1614 AN------------KKKPSM------------PNVSNDLSQKLYATMEK--HKEVFFVIHLHAGP 1652

  Fly   979 IQNREPSLRDSNP-----------------DEIEIDFETLKPS---------------------T 1005
            :.:.:|.:.|.:|                 .:...:|.:|:.|                     |
Mouse  1653 VISTQPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYT 1717

  Fly  1006 LRELESYVAS------------CL-----RKKTHK--------KPSGKSKDEQMAEKKQE----- 1040
            ..|.:.:|.:            |:     :..|||        ...|.|:.|..::..||     
Mouse  1718 CNECKHHVETRWHCTVCEDYDLCINCYNTKSHTHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLS 1782

  Fly  1041 -----------------------LEKRLQDVTGQLGASKKT-----------------AK----- 1060
                                   .:|..:.|....|..:||                 ||     
Mouse  1783 IQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQEN 1847

  Fly  1061 --------------KDESASSKVEAVQ-PANPVSSSSSSSDSSSSSSSDSSSSDSSDSEAVLVIP 1110
                          :.:....:::..| ....:::.::.:....|..|.:|:...:.::      
Mouse  1848 KCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQ------ 1906

  Fly  1111 APTGDGDERPPRKKKSRDSNGSNVNNPSINVVMGGNLPSGALSPTTMLMGLDHVVNSNTPTSQMS 1175
            .|:.....:||.:.:....|.|....|::          ....|.|       :|::..||:|:.
Mouse  1907 QPSTPQTPQPPAQPQPSPVNMSPAGFPNV----------ARTQPPT-------IVSAGKPTNQVP 1954

  Fly  1176 NMLGNANPLTAA-------------------AMLNNNNKTSLPGSNFGGAPAPGNMM-HAGAGVP 1220
            .....|.|..||                   |.:||...   ||.  .|...||:.| ..|..||
Mouse  1955 APPPPAQPPPAAVEAARQIEREAQQQQHLYRANINNGMP---PGR--AGMGTPGSQMTPVGLNVP 2014

  Fly  1221 ----VAGAAVSASTGQQHNKNGPNDLSKVQPGGP-------INAAL---------PPHSFAGG-- 1263
                |:|..:|:....|. :..|....:..||.|       ..||:         ||.|.:..  
Mouse  2015 RPNQVSGPVMSSMPPGQW-QQAPIPQQQPMPGMPRPVMSMQAQAAVAGPRMPNVQPPRSISPSAL 2078

  Fly  1264 -------------------------------------TATVATS----------QSSGGIRIASN 1281
                                                 ||....:          ||..|::....
Mouse  2079 QDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPG 2143

  Fly  1282 LH-KPSGLGGGDLGEHHAALAAALTSGINSTGTAGGGINNNGGSNNNANPLGGSHGDAMVNASLA 1345
            :| :||      |...:|..|.....|:.....|.||:|..|.:.|..||   .|...|.|.:  
Mouse  2144 MHQQPS------LQNLNAMQAGVPRPGVPPPQPAMGGLNPQGQALNIMNP---GHNPNMTNMN-- 2197

  Fly  1346 SLASGLKQIPQFDDPVEQSLASLEFSAGSTGKSGLTDNFLMQQHLMQPAGPQQQQQQQQQQPFGH 1410
                     ||:.:                         ::::.|:|                 |
Mouse  2198 ---------PQYRE-------------------------MVRRQLLQ-----------------H 2211

  Fly  1411 QQQQQQQQQQQQQQQQHMDYVTELLSKGAENVGGMNGNHLLNFNLDMAAAYQQKHPQQQQQQAHN 1475
            |||||||||||||||           ..|...|||.|                 |.|.||.|   
Mouse  2212 QQQQQQQQQQQQQQQ-----------NSASLAGGMAG-----------------HSQFQQPQ--- 2245

  Fly  1476 NGFNVADFGMAGFDGLNMTAASFLDLEPSLQQQQMQQMQLQQQHHQQQQQQTHQQQQQHQQQHHQ 1540
                    |..|:             .|::|||:|||       |...|..:..|......|..|
Mouse  2246 --------GPGGY-------------APAMQQQRMQQ-------HLPIQGSSMGQMAAPMGQLGQ 2282

  Fly  1541 QQQ-----------QQQLTQQQLQQQQQQQQ-----------QQQHLQQQQHQQQH---HQAANK 1580
            ..|           ||.|.|:.|||||.:||           .|||:...|.|..|   .|.|..
Mouse  2283 MGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATS 2347

  Fly  1581 L---LIIPKPIESMMP--SPPDKQQLQQHQKVLP---PQQSP---SDMKLHPNAAAAAAVASAQA 1634
            |   :..|.|::|..|  .||       |....|   ||.||   |.....|:...|..:||:. 
Mouse  2348 LSNQVRSPAPVQSPRPQSQPP-------HSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSM- 2404

  Fly  1635 KLVQTFKANEQNLKNASSWSSLASANSPQSHTSSSSSSSKAKPAMDSFQQF 1685
                    ::.:|.|....:.|...|:|.....||..|.......|:.::|
Mouse  2405 --------DQGHLGNPEQSAMLPQLNTPNRSALSSELSLVGDTTGDTLEKF 2447

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fs(1)hNP_001259321.1 Bromo_Brdt_I_like 34..140 CDD:99929 20/147 (14%)
COG5076 387..>593 CDD:227408 56/253 (22%)
Bromo_Brdt_II_like 481..581 CDD:99930 38/128 (30%)
BET 951..1015 CDD:293640 15/105 (14%)
BRD4_CDT <2026..2046 CDD:293710
CrebbpXP_006521814.1 zf-TAZ 362..429 CDD:366931
KIX 586..666 CDD:366953 15/92 (16%)
PHA03247 <687..1037 CDD:223021 70/366 (19%)
COG5076 942..>1194 CDD:227408 64/290 (22%)
Bromo_cbp_like 1088..1195 CDD:99927 41/111 (37%)
RING_CBP-p300 1207..1289 CDD:276805 13/85 (15%)
PHD_CBP_p300 1291..1322 CDD:277032 0/30 (0%)
HAT_KAT11 1353..>1564 CDD:369758 34/220 (15%)
ZZ_CBP 1716..1756 CDD:239077 7/39 (18%)
ZnF_TAZ 1777..1855 CDD:214717 8/77 (10%)
Med15 1971..>2422 CDD:312941 133/593 (22%)
Creb_binding 2045..2125 CDD:370251 9/79 (11%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.