Protein Alignment fs(1)h and brd4

DIOPT Version :10

• Sequence 1: NP_001259321.1
• Gene: fs(1)h / 31722
• FlyBaseID: FBgn0004656
• Length: 2046
• Species: Drosophila melanogaster
• Sequence 2: XP_017947469.1
• Gene: brd4 / 100216259
• XenbaseID: XB-GENE-5859147
• Length: 1400
• Species: Xenopus tropicalis
• Alignment Length: 2147
• Identity: 554/2147 - (25%)
• Similarity: 724/2147 - (33%)
• Gaps: 911/2147 - (42%)

  Fly     1 MSSSEPPPRYEPPVEPVNGIVQPPVIPPAERPG---RNTNQLQYLIKTVMKVIWKHHFSWPFQQP 62
            ||..:.|...:|  :|.|..:..|..|...||.   |.|||||||:|||:|.:|||.|:||||.|
 Frog    62 MSGQQLPAAPQP--QPQNSSLLNPPPPDIARPSQAKRQTNQLQYLLKTVLKTLWKHQFAWPFQLP 124

  Fly    63 VDAKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQ 127
            ||..||||||||||||.|||||||||||||:|||:|:|.||||||||.|||:|||||:|:|:||:
 Frog   125 VDVVKLNLPDYHKIIKNPMDMGTIKKRLENHYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAE 189

  Fly   128 TLEKVFLQKIESMPKEELELEPVTAKG---GKKKQR------APATPKSSSGGAGASTGSGTSSA 183
            .|||:|||||..||:||.||..|.:||   |:|:|.      .|...:..||..|       ..:
 Frog   190 ALEKLFLQKISEMPQEETELAVVQSKGRGRGRKEQSEQDTSITPMRTRVLSGSLG-------DKS 247

  Fly   184 AVTSGPGSGSTKVSVAASSAQQSGLQGATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSS 248
            ||...|   .|.||..|:....:..:..|        .|.|:|..      .|||
 Frog   248 AVKPPP---VTPVSKPATPTPPTVTRAPT--------PPQTRPPQ------QARP---------- 285

  Fly   249 TAGGAPSI--PPISTMPPHTVPGSTNTTTTAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYP 311
                 |:|  .|||..|  |:.......||.....|..|     .||.
 Frog   286 -----PAITQAPISFSP--TISQDVVVPTTVAPTPVPQP-----LPNH----------------- 321

  Fly   312 GAPGQTAVNSSSLLDGSTAAVAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNA 376
                                                            |||...||
 Frog   322 ------------------------------------------------PAVIHTAA--------- 329

  Fly   377 GVSVGVDAVIPPQQPAKIKKGVKRKADTTTPTAN--AFESPYTQMDSKSAKIATRRESNRQVIGK 439
                         ||||.||||||||||||||.:  ..||.....|||..|...|:||.||:...
 Frog   330 -------------QPAKTKKGVKRKADTTTPTTHDPLHESSPLPSDSKPPKAGPRKESGRQIRPT 381

  Fly   440 KGSGYNMSPLGVSGV----PGLGGLVAGGVAGVAVAKNKEKLSDALKSCNEILKELFSKKHSGYA 500
            |.:....|.|....|    |            ...|:...|.|:.|:.|..|::|:|||||..||
 Frog   382 KKTEVPDSQLPAPPVLQPQP------------TPTAEKDSKTSEQLRYCAGIIREMFSKKHQAYA 434

  Fly   501 WPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHD 565
            ||||||||.:.||||||.:|||.||||||:|.||||.:||.|.|||:||||:|:||||||||||:
 Frog   435 WPFYKPVDVDALGLHDYREIIKHPMDLGTIKVKMDNWDYKDAKEFASDVRLMFSNCYKYNPPDHE 499

  Fly   566 VVAMGRKLQDVFEMRYANIPDEPVANAAHHHGHGHGHGHGHGHGHGHGHGHGHGHGYGGSSSLK- 629
            ||.|.||||||||||||.:||||....|.......|                     ..:.|:|
 Frog   500 VVIMARKLQDVFEMRYAKMPDEPEEAPAPAPSPAPG---------------------PPAPSIKG 543

  Fly   630 --HDASDSSSEDSSDTENESNSDEERSARLKMLESKLLGLQEEIRKLSEEASAKKKAKKKLKEKK 692
              ..:|||||:.|||:|:.|:|:|||:.||..|:.:|..:.|::..||:....|.|.|::.|.|:
 Frog   544 PPPTSSDSSSDSSSDSESSSDSEEERAQRLAELQEQLKAVHEQLAALSQPQPNKPKKKEREKRKE 608

  Fly   693 KSIGGGSGSGSASHHCHATGGGANAGGAGGPGSGGHGSVSVPGGVGSLGPGGAGGANLNALLGGS 757
            |
 Frog   609 K---------------------------------------------------------------- 609

  Fly   758 LVGHGGAAVAGGVPNVGALHSQVHDVAMAFSQMAGGGAAAGAGFGAGVTAAGASSGGKAGTLAGA 822
                               |.:..:|
 Frog   610 -------------------HKRKEEV--------------------------------------- 616

  Fly   823 LAAGAAAGAGGTTAGSGSSKGAKSKGGR----GAKGSGAGGVGASNNAAAGNAAGGAAGAAAGAG 883
                                 .:.:.||    .||
 Frog   617 ---------------------EEPRKGRIREPPAK------------------------------ 630

  Fly   884 SVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVGGANASAGGAGARGSSKKKPSQVMNFDSEEEDT 948
                                |...|....||.......|....||.:....|........||...
 Frog   631 --------------------KPKKSVQGSGGTPSIKKEAPPPVARPARPVPPPAPCESSEEETQR 675

  Fly   949 AKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSLRDSNPDEIEIDFETLKPSTLRELESYV 1013
            .:||||:||||||||||||||:||||||||||:|||||::||||||||||||||||||||||.||
 Frog   676 CRPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYV 740

  Fly  1014 ASCLRKKTHKKPSGKSKDEQMAEKKQELEKRLQDVTGQLGASKKTAKKDESASSKVEAVQPANPV 1078
            .||||||  :||                    ||                    |:||  |.:..
 Frog   741 TSCLRKK--RKP--------------------QD--------------------KIEA--PTSGT 761

  Fly  1079 SSSSSSSDSSSSSSSDSSSSDSSDSEAVLVIPAPTGDGDERPPRKKKSRDSNGSNVNNPSINVVM 1143
            ......|.|.|.|||:||:|||.:|           |.:..|.:|||......|..::..:...:
 Frog   762 GKVKGYSSSESESSSESSTSDSEES-----------DPETAPNQKKKGHSGRESRKHHHPMQQPL 815

  Fly  1144 GGNLPSGALSPTTMLMGLDHVVNSNTPTSQMS--NMLGNANPLTAAAMLNNNNKTSLPGSNFGGA 1206
            ..  |...:.|.:..:...:...|:..:|..|  :.|.:||...|...|..:....|.|.....:
 Frog   816 AA--PPPVMKPPSPTLAPPYPPPSSLDSSHPSLHHPLHSANVFDAVMQLPPDLPPHLTGQTEHCS 878

  Fly  1207 PAPGNMMHAGAGVPVAGAAVSASTGQQHNKNGPNDLSKVQPGGPINAALP-----PHSFAGGTAT 1266
            | |....||....|....|:.....:..|:........|||.. ::..||     ||
 Frog   879 P-PHLNQHALTSPPALHNAMPQQPSRPSNRAAALPPKPVQPPS-VSPPLPPPPPQPH-------- 933

  Fly  1267 VATSQSSGGIRIASNLHKPSGLGGGDLGEHHAALAAALTSGINSTGTAGGGINNNGGSNNNANP- 1330
                            |:||      :..||                          .:::|.|
 Frog   934 ----------------HQPS------VHIHH--------------------------HHHHAQPP 950

  Fly  1331 --LGGSHGDAMVNASLASLASGLK--QIPQFDDPVEQSLASLEFSAGSTGKSGLTDNFLMQQHLM 1391
              |....|....:..|.|....|:  |.|....|:...|.|::                :|....
 Frog   951 HALLEDDGPPSPHTGLPSYLQQLQKPQQPPTQSPIHSLLTSVK----------------VQSQAP 999

  Fly  1392 QPAGPQQQQ-------------------------QQQQQQPFGHQQQQQQQQQQQQQQQQHMDYV 1431
            ..|.||..:                         .|.|..|...|||...|.....|||||....
 Frog  1000 MAAPPQSMRHLQPLVYPAPSSTATTAPPPASSHIHQLQSSPAVPQQQPAGQAPPPPQQQQHPALQ 1064

  Fly  1432 TELLSKGAENVGGMNGNHLLNFNLDMAAAYQQKHPQQQQQQAHNNGFNVADFGMAGFDGLNMTAA 1496
            ..|:|                           .|||.
 Frog  1065 GALVS---------------------------SHPQH---------------------------- 1074

  Fly  1497 SFLDLEPSLQQQQMQQMQLQQQHH---QQQQQQT---------------------------HQQQ 1531
                    :|.||.:|.|:.|.||   :||:|:|                           |...
 Frog  1075 --------VQHQQAKQQQVIQHHHPSPRQQKQETYAGGHLRDAPSPLLLHSPQVPPYPGLAHPPS 1131

  Fly  1532 QQHQQQHHQQQQQQQLTQQQLQQQQQQQQQQQHLQQQQHQQQHHQAANKLLIIPKPIESMMPSPP 1596
            .|..|...|:.:...:.|.|....::.::....|:.:...........|:..:.|....:.|.|.
 Frog  1132 PQSVQPKKQEMRGASVLQPQPLVMKEDKRHSPSLRPEGFSPGMRPEPQKVPEVLKGSSHIQPRPD 1196

  Fly  1597 DK-----QQLQQHQKVLPPQQSP--SDMKLHPNAAAAAAVASAQAKLVQTFKANEQNLKNASSWS 1654
            .|     :.::...:.||||..|  ...|..|....|              ...:..:||..||:
 Frog  1197 LKPMDVGRPIRPTDQSLPPQGMPEKEKQKQEPKTPVA--------------PKKDIKIKNMGSWA 1247

  Fly  1655 SLASANSPQSHTSSSSSSSKAKPAMDSFQQFRNKAKERDRLKLLEAAEKEKKNQKEAAEKEQQRK 1719
            .|.. ..|.:.||:..|:|      |||:.||.:|:|::.   .|.|.|.:..|.|...:||:|.
 Frog  1248 GLMQ-KPPVTPTSAGKSTS------DSFELFRRQAREKEE---RERALKLQAEQAERMRREQERM 1302

  Fly  1720 HHKSSSSSLTSAAVAQAAAIAAATAAAAVTLGAAAAAALASSASNPSGGSSSGGAGSTSQQAITG 1784
            ..:....:...|..|...|
 Frog  1303 RSRDEDDAQEQARKAHEEA---------------------------------------------- 1321

  Fly  1785 DRDRDRDRERERERSGSGGGQSGNGNNSSNSANSNGPGSAGSGGSGGGGGSGPASAGGPNSGGGG 1849
             |.|...:::::::
 Frog  1322 -RRRQEQQQQQQQQ--------------------------------------------------- 1334

  Fly  1850 TANSNSGGGGGGGGPALLNAGSNSNSGVGSGGAASSNSNSSVGGIVGSGGPGSNSQGSSGGGGGG 1914
                                                                             
 Frog  1335 ----------------------------------------------------------------- 1334

  Fly  1915 PASGGGMGSGAIDYGQQVAVLTQVAANAQAQHVAAAVAAQAILAASPLGAMESGRKSVHDAQPQI 1979
                           ||           |.|||      |:.|.|:|
 Frog  1335 ---------------QQ-----------QQQHV------QSNLPAAP------------------ 1349

  Fly  1980 SRVEDIKASPGGQGQSSPAQQSPQDRAAAKRAEQRRAEQERRRREALAGQIDMNMQSDLMAAFEE 2044
                            ||||.|  .....:|...|:.|||||||:|:|..||||.||:||..||:
 Frog  1350 ----------------SPAQSS--QPIMDQREMARKREQERRRRQAMAPSIDMNFQSELMEIFEQ 1396

  Fly  2045 TL 2046
            .|
 Frog  1397 NL 1398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	81/105 (77%)
		COG5076	387..>593	CDD:227408	116/211 (55%)
		Bromo_Brdt_II_like	481..581	CDD:99930	72/99 (73%)
		BET	951..1015	CDD:435704	57/63 (90%)
		BRD4_CDT	<2026..2046	CDD:465349	11/19 (58%)
brd4	XP_017947469.1	Bromo_Brdt_I_like	96..202	CDD:99929	81/105 (77%)
		PHA03247	<251..406	CDD:223021	64/292 (22%)
		Bromo_Brdt_II_like	414..515	CDD:99930	72/100 (72%)
		BET	678..742	CDD:435704	57/63 (90%)
		BRD4_CDT	1361..1399	CDD:465349	22/38 (58%)