DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fs(1)h and brd4

DIOPT Version :9

Sequence 1:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster
Sequence 2:	XP_017947469.1	Gene:	brd4 / 100216259	XenbaseID:	XB-GENE-5859147	Length:	1400	Species:	Xenopus tropicalis

Alignment Length:	2147	Identity:	554/2147 - (25%)
Similarity:	724/2147 - (33%)	Gaps:	911/2147 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSSEPPPRYEPPVEPVNGIVQPPVIPPAERPG---RNTNQLQYLIKTVMKVIWKHHFSWPFQQP 62
            ||..:.|...:|  :|.|..:..|..|...||.   |.|||||||:|||:|.:|||.|:||||.|
Frog    62 MSGQQLPAAPQP--QPQNSSLLNPPPPDIARPSQAKRQTNQLQYLLKTVLKTLWKHQFAWPFQLP 124

  Fly    63 VDAKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQ 127
            ||..||||||||||||.|||||||||||||:|||:|:|.||||||||.|||:|||||:|:|:||:
Frog   125 VDVVKLNLPDYHKIIKNPMDMGTIKKRLENHYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAE 189

  Fly   128 TLEKVFLQKIESMPKEELELEPVTAKG---GKKKQR------APATPKSSSGGAGASTGSGTSSA 183
            .|||:|||||..||:||.||..|.:||   |:|:|.      .|...:..||..|       ..:
Frog   190 ALEKLFLQKISEMPQEETELAVVQSKGRGRGRKEQSEQDTSITPMRTRVLSGSLG-------DKS 247

  Fly   184 AVTSGPGSGSTKVSVAASSAQQSGLQGATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSS 248
            ||...|   .|.||..|:....:..:..|        .|.|:|..      .|||
Frog   248 AVKPPP---VTPVSKPATPTPPTVTRAPT--------PPQTRPPQ------QARP---------- 285

  Fly   249 TAGGAPSI--PPISTMPPHTVPGSTNTTTTAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYP 311
                 |:|  .|||..|  |:.......||.....|..|     .||.
Frog   286 -----PAITQAPISFSP--TISQDVVVPTTVAPTPVPQP-----LPNH----------------- 321

  Fly   312 GAPGQTAVNSSSLLDGSTAAVAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNA 376
                                                            |||...||
Frog   322 ------------------------------------------------PAVIHTAA--------- 329

  Fly   377 GVSVGVDAVIPPQQPAKIKKGVKRKADTTTPTAN--AFESPYTQMDSKSAKIATRRESNRQVIGK 439
                         ||||.||||||||||||||.:  ..||.....|||..|...|:||.||:...
Frog   330 -------------QPAKTKKGVKRKADTTTPTTHDPLHESSPLPSDSKPPKAGPRKESGRQIRPT 381

  Fly   440 KGSGYNMSPLGVSGV----PGLGGLVAGGVAGVAVAKNKEKLSDALKSCNEILKELFSKKHSGYA 500
            |.:....|.|....|    |            ...|:...|.|:.|:.|..|::|:|||||..||
Frog   382 KKTEVPDSQLPAPPVLQPQP------------TPTAEKDSKTSEQLRYCAGIIREMFSKKHQAYA 434

  Fly   501 WPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHD 565
            ||||||||.:.||||||.:|||.||||||:|.||||.:||.|.|||:||||:|:||||||||||:
Frog   435 WPFYKPVDVDALGLHDYREIIKHPMDLGTIKVKMDNWDYKDAKEFASDVRLMFSNCYKYNPPDHE 499

  Fly   566 VVAMGRKLQDVFEMRYANIPDEPVANAAHHHGHGHGHGHGHGHGHGHGHGHGHGHGYGGSSSLK- 629
            ||.|.||||||||||||.:||||....|.......|                     ..:.|:|
Frog   500 VVIMARKLQDVFEMRYAKMPDEPEEAPAPAPSPAPG---------------------PPAPSIKG 543

  Fly   630 --HDASDSSSEDSSDTENESNSDEERSARLKMLESKLLGLQEEIRKLSEEASAKKKAKKKLKEKK 692
              ..:|||||:.|||:|:.|:|:|||:.||..|:.:|..:.|::..||:....|.|.|::.|.|:
Frog   544 PPPTSSDSSSDSSSDSESSSDSEEERAQRLAELQEQLKAVHEQLAALSQPQPNKPKKKEREKRKE 608

  Fly   693 KSIGGGSGSGSASHHCHATGGGANAGGAGGPGSGGHGSVSVPGGVGSLGPGGAGGANLNALLGGS 757
            |
Frog   609 K---------------------------------------------------------------- 609

  Fly   758 LVGHGGAAVAGGVPNVGALHSQVHDVAMAFSQMAGGGAAAGAGFGAGVTAAGASSGGKAGTLAGA 822
                               |.:..:|
Frog   610 -------------------HKRKEEV--------------------------------------- 616

  Fly   823 LAAGAAAGAGGTTAGSGSSKGAKSKGGR----GAKGSGAGGVGASNNAAAGNAAGGAAGAAAGAG 883
                                 .:.:.||    .||
Frog   617 ---------------------EEPRKGRIREPPAK------------------------------ 630

  Fly   884 SVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVGGANASAGGAGARGSSKKKPSQVMNFDSEEEDT 948
                                |...|....||.......|....||.:....|........||...
Frog   631 --------------------KPKKSVQGSGGTPSIKKEAPPPVARPARPVPPPAPCESSEEETQR 675

  Fly   949 AKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSLRDSNPDEIEIDFETLKPSTLRELESYV 1013
            .:||||:||||||||||||||:||||||||||:|||||::||||||||||||||||||||||.||
Frog   676 CRPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYV 740

  Fly  1014 ASCLRKKTHKKPSGKSKDEQMAEKKQELEKRLQDVTGQLGASKKTAKKDESASSKVEAVQPANPV 1078
            .||||||  :||                    ||                    |:||  |.:..
Frog   741 TSCLRKK--RKP--------------------QD--------------------KIEA--PTSGT 761

  Fly  1079 SSSSSSSDSSSSSSSDSSSSDSSDSEAVLVIPAPTGDGDERPPRKKKSRDSNGSNVNNPSINVVM 1143
            ......|.|.|.|||:||:|||.:|           |.:..|.:|||......|..::..:...:
Frog   762 GKVKGYSSSESESSSESSTSDSEES-----------DPETAPNQKKKGHSGRESRKHHHPMQQPL 815

  Fly  1144 GGNLPSGALSPTTMLMGLDHVVNSNTPTSQMS--NMLGNANPLTAAAMLNNNNKTSLPGSNFGGA 1206
            ..  |...:.|.:..:...:...|:..:|..|  :.|.:||...|...|..:....|.|.....:
Frog   816 AA--PPPVMKPPSPTLAPPYPPPSSLDSSHPSLHHPLHSANVFDAVMQLPPDLPPHLTGQTEHCS 878

  Fly  1207 PAPGNMMHAGAGVPVAGAAVSASTGQQHNKNGPNDLSKVQPGGPINAALP-----PHSFAGGTAT 1266
            | |....||....|....|:.....:..|:........|||.. ::..||     ||
Frog   879 P-PHLNQHALTSPPALHNAMPQQPSRPSNRAAALPPKPVQPPS-VSPPLPPPPPQPH-------- 933

  Fly  1267 VATSQSSGGIRIASNLHKPSGLGGGDLGEHHAALAAALTSGINSTGTAGGGINNNGGSNNNANP- 1330
                            |:||      :..||                          .:::|.|
Frog   934 ----------------HQPS------VHIHH--------------------------HHHHAQPP 950

  Fly  1331 --LGGSHGDAMVNASLASLASGLK--QIPQFDDPVEQSLASLEFSAGSTGKSGLTDNFLMQQHLM 1391
              |....|....:..|.|....|:  |.|....|:...|.|::                :|....
Frog   951 HALLEDDGPPSPHTGLPSYLQQLQKPQQPPTQSPIHSLLTSVK----------------VQSQAP 999

  Fly  1392 QPAGPQQQQ-------------------------QQQQQQPFGHQQQQQQQQQQQQQQQQHMDYV 1431
            ..|.||..:                         .|.|..|...|||...|.....|||||....
Frog  1000 MAAPPQSMRHLQPLVYPAPSSTATTAPPPASSHIHQLQSSPAVPQQQPAGQAPPPPQQQQHPALQ 1064

  Fly  1432 TELLSKGAENVGGMNGNHLLNFNLDMAAAYQQKHPQQQQQQAHNNGFNVADFGMAGFDGLNMTAA 1496
            ..|:|                           .|||.
Frog  1065 GALVS---------------------------SHPQH---------------------------- 1074

  Fly  1497 SFLDLEPSLQQQQMQQMQLQQQHH---QQQQQQT---------------------------HQQQ 1531
                    :|.||.:|.|:.|.||   :||:|:|                           |...
Frog  1075 --------VQHQQAKQQQVIQHHHPSPRQQKQETYAGGHLRDAPSPLLLHSPQVPPYPGLAHPPS 1131

  Fly  1532 QQHQQQHHQQQQQQQLTQQQLQQQQQQQQQQQHLQQQQHQQQHHQAANKLLIIPKPIESMMPSPP 1596
            .|..|...|:.:...:.|.|....::.::....|:.:...........|:..:.|....:.|.|.
Frog  1132 PQSVQPKKQEMRGASVLQPQPLVMKEDKRHSPSLRPEGFSPGMRPEPQKVPEVLKGSSHIQPRPD 1196

  Fly  1597 DK-----QQLQQHQKVLPPQQSP--SDMKLHPNAAAAAAVASAQAKLVQTFKANEQNLKNASSWS 1654
            .|     :.::...:.||||..|  ...|..|....|              ...:..:||..||:
Frog  1197 LKPMDVGRPIRPTDQSLPPQGMPEKEKQKQEPKTPVA--------------PKKDIKIKNMGSWA 1247

  Fly  1655 SLASANSPQSHTSSSSSSSKAKPAMDSFQQFRNKAKERDRLKLLEAAEKEKKNQKEAAEKEQQRK 1719
            .|.. ..|.:.||:..|:|      |||:.||.:|:|::.   .|.|.|.:..|.|...:||:|.
Frog  1248 GLMQ-KPPVTPTSAGKSTS------DSFELFRRQAREKEE---RERALKLQAEQAERMRREQERM 1302

  Fly  1720 HHKSSSSSLTSAAVAQAAAIAAATAAAAVTLGAAAAAALASSASNPSGGSSSGGAGSTSQQAITG 1784
            ..:....:...|..|...|
Frog  1303 RSRDEDDAQEQARKAHEEA---------------------------------------------- 1321

  Fly  1785 DRDRDRDRERERERSGSGGGQSGNGNNSSNSANSNGPGSAGSGGSGGGGGSGPASAGGPNSGGGG 1849
             |.|...:::::::
Frog  1322 -RRRQEQQQQQQQQ--------------------------------------------------- 1334

  Fly  1850 TANSNSGGGGGGGGPALLNAGSNSNSGVGSGGAASSNSNSSVGGIVGSGGPGSNSQGSSGGGGGG 1914

Frog  1335 ----------------------------------------------------------------- 1334

  Fly  1915 PASGGGMGSGAIDYGQQVAVLTQVAANAQAQHVAAAVAAQAILAASPLGAMESGRKSVHDAQPQI 1979
                           ||           |.|||      |:.|.|:|
Frog  1335 ---------------QQ-----------QQQHV------QSNLPAAP------------------ 1349

  Fly  1980 SRVEDIKASPGGQGQSSPAQQSPQDRAAAKRAEQRRAEQERRRREALAGQIDMNMQSDLMAAFEE 2044
                            ||||.|  .....:|...|:.|||||||:|:|..||||.||:||..||:
Frog  1350 ----------------SPAQSS--QPIMDQREMARKREQERRRRQAMAPSIDMNFQSELMEIFEQ 1396

  Fly  2045 TL 2046
            .|
Frog  1397 NL 1398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	81/105 (77%)
		COG5076	387..>593	CDD:227408	116/211 (55%)
		Bromo_Brdt_II_like	481..581	CDD:99930	72/99 (73%)
		BET	951..1015	CDD:293640	57/63 (90%)
		BRD4_CDT	<2026..2046	CDD:293710	11/19 (58%)
brd4	XP_017947469.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4178
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	1	1.000	-	-		otm48264
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X197
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.000