Protein Alignment HNF4A and Hr83

DIOPT Version :10

• Sequence 1: NP_000448.3
• Gene: HNF4A / 3172
• HGNCID: 5024
• Length: 474
• Species: Homo sapiens
• Sequence 2: NP_649647.1
• Gene: Hr83 / 40783
• FlyBaseID: FBgn0037436
• Length: 278
• Species: Drosophila melanogaster
• Alignment Length: 310
• Identity: 88/310 - (28%)
• Similarity: 134/310 - (43%)
• Gaps: 87/310 - (28%)

Human    60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSC-RFSRQCVVDKDKRNQCRYCRLKKCFRA 123
            ||:|||:::|||||.|.||||..||:||||:...|:| .....|||||.:||.|..||.::|...
  Fly     7 CAVCGDQSSGKHYGVSCCDGCSCFFKRSVRRGSSYACIALVGNCVVDKARRNWCPSCRFQRCLAV 71

Human   124 GMKKEAVQNER----DRIST----RRSSYEDSSLPSINALLQA---EVLSRQITSPVSGINGDIR 177
            ||...|||.||    .:::.    ||.:....:.||.....||   ::|::.:.:.:.    ..:
  Fly    72 GMNAAAVQEERGPRNQQVALYRTGRRQAPPSQAAPSPTPHSQALHFQILAQILVTCLR----QAK 132

Human   178 AKKIASIADVCES------MKEQLLVL--VEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATK 234
            |.:..::.|.|:.      :..::.||  ..|:..|.|..:...|:|:..|...|  |.|..
  Fly   133 ANEQFALLDRCQQDAIFQVVWSEIFVLRASHWSLDISAMIDGCGDEQLKRLICEA--HQLRA--- 192

Human   235 RSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYL-----KAIIF 294
                  |||                     .:..::.|:|..:||.| :.|||.:     ||.:
  Fly   193 ------DVL---------------------ELNFMESLILCRKELAI-NAEYAVILGSHSKAAL- 228

Human   295 FDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTL 344
                         |...|..:|.|  :|:         |||:|||.|..|
  Fly   229 -------------ISLARYTLQQS--NYL---------RFGQLLLGLRQL 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNF4A	NP_000448.3	NR_DBD_HNF4A	60..135	CDD:143518	41/79 (52%)
		NR_LBD_HNF4_like	151..373	CDD:132729	44/210 (21%)
		9aaTAD. /evidence=ECO:0000269|PubMed:30468856	368..376
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..447
Hr83	NP_649647.1	NR_DBD_PNR_like_2	7..88	CDD:143515	41/80 (51%)