Protein Alignment HNF4A and Hr78

DIOPT Version :10

• Sequence 1: NP_000448.3
• Gene: HNF4A / 3172
• HGNCID: 5024
• Length: 474
• Species: Homo sapiens
• Sequence 2: NP_730636.1
• Gene: Hr78 / 40378
• FlyBaseID: FBgn0015239
• Length: 601
• Species: Drosophila melanogaster
• Alignment Length: 581
• Identity: 121/581 - (20%)
• Similarity: 184/581 - (31%)
• Gaps: 246/581 - (42%)

Human    37 GNDTSPSEGTNLNAPNSLGVSA-LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSR 100
            |....|..|..:.|..|..:|. ||.:|||||:|:||||.||:||||||:||:||...|.||.:.
  Fly    28 GGTPLPGGGVGMGAGASATLSVELCLVCGDRASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGAM 92

Human   101 QCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRR-------------------SSY-- 144
            .|.|.|..||:|::|||:||..:||:.::||:||..|..|:                   |:|
  Fly    93 NCEVTKHHRNRCQFCRLQKCLASGMRSDSVQHERKPIVDRKEGIIAAAGSSSTSGGGNGSSTYLS 157

Human   145 ----------------------------------------------------------------- 144
                                                                             
  Fly   158 GKSGYQQGRGKGHSVKAESAATPPVHSAPATAFNLNENIFPMGLNFAELTQTLMFATQQQQQQQQ 222

Human   145 --------------------EDSS----------------------------------LPS---- 151
                                ||.|                                  ||:
  Fly   223 QHQQSGSYSPDIPKADPEDDEDDSMDNSSTLCLQLLANSASNNNSQHLNFNAGEVPTALPTTSTM 287

Human   152 --INALLQAEVLSR--QITSPVSG---INGDIRAK------------------------------ 179
              |.:.|...|:.:  ||..|:..   .||::..|
  Fly   288 GLIQSSLDMRVIHKGLQILQPIQNQLERNGNLSVKPECDSEAEDSGTEDAVDAELEHMELDFECG 352

Human   180 -------------------------------------KIASIADVCESMKEQLLVLVEWAKYIPA 207
                                                 ...:|..|||:....:.:.:...:.:|.
  Fly   353 GNRSGGSDFAINEAVFEQDLLTDVQCAFHVQPPTLVHSYLNIHYVCETGSRIIFLTIHTLRKVPV 417

Human   208 FCELPLDDQVALLR-----------AHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEM 261
            |.:|....||.|||           |.....|.:.......:.....|...|.|.|....::|.:
  Fly   418 FEQLEAHTQVKLLRGVWPALMAIALAQCQGQLSVPTIIGQFIQSTRQLADIDKIEPLKISKMANL 482

Human   262 SRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDP----DAKGLSDPGKIKRLRSQVQVSLEDY 322
            :|.    |.:.|...|.|.:.|.|:..|:.|:.|:|    ..|..|..|.::|::.....||.
  Fly   483 TRT----LHDFVQELQSLDVTDMEFGLLRLILLFNPTLLQQRKERSLRGYVRRVQLYALSSLR-- 541

Human   323 INDRQYDSRG---RFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPS 380
               ||....|   ||..|:..|..|.|:..:.:|::.|..|.|..::|.|:..:|:..:.|
  Fly   542 ---RQGGIGGGEERFNVLVARLLPLSSLDAEAMEELFFANLVGQMQMDALIPFILMTSNTS 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNF4A	NP_000448.3	NR_DBD_HNF4A	60..135	CDD:143518	42/74 (57%)
		NR_LBD_HNF4_like	151..373	CDD:132729	60/317 (19%)
		9aaTAD. /evidence=ECO:0000269|PubMed:30468856	368..376		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..447
Hr78	NP_730636.1	NR_DBD_TR2_like	47..133	CDD:143525	46/85 (54%)
		NR_LBD_TR2_like	372..595	CDD:132750	52/231 (23%)