Protein Alignment HNF4A and dsf

DIOPT Version :10

• Sequence 1: NP_000448.3
• Gene: HNF4A / 3172
• HGNCID: 5024
• Length: 474
• Species: Homo sapiens
• Sequence 2: NP_477140.1
• Gene: dsf / 33823
• FlyBaseID: FBgn0015381
• Length: 691
• Species: Drosophila melanogaster
• Alignment Length: 671
• Identity: 124/671 - (18%)
• Similarity: 181/671 - (26%)
• Gaps: 359/671 - (53%)

Human    60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCR----FSRQCVVDKDKRNQCRYCRLKKC 120
            |.:||||::|||||..|||||.|||:||:.:|.:|:|:    ...:|.|||..|||||.|||.||
  Fly    13 CKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKTHRNQCRACRLAKC 77

Human   121 FRAGMKKEAVQNER--------------------------------------------------- 134
            |::.|.|:|||:||
  Fly    78 FQSAMNKDAVQHERGPRKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHHHHHHHAHAAAAHHAAV 142

Human   135 ------------------------------DRISTR----------------------------- 140
                                          ..|||.
  Fly   143 AAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAPPSGFHLTASGAQQGPAPPAGHL 207

Human   141 -----------------------------------RSS------------------------YED 146
                                               .||                        ...
  Fly   208 HHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGPGSTLPFPSHLLHHNLIAEAA 272

Human   147 SSLPSINALLQAEVLS---------RQITSP------------------VSGI------------ 172
            |.||.|.|...|.|:|         .|.:||                  :|.|
  Fly   273 SKLPGITATAVAAVVSSTSTPYASAAQTSSPSSNNHNYSSPSPSNSIQSISSIGSRSGGGEEGLS 337

Human   173 ----------------------------------------------------------------- 172
                                                                             
  Fly   338 LGSESPRVNVETETPSPSNSPPLSAGSISPAPTLTTSSGSPQHRQMSRHSLSEATTPPSHASLMI 402

Human   173 --------------NGDIRAKKIAS-----------------------------------IADVC 188
                          ||:.:.....|                                   ..|.|
  Fly   403 CASNNNNNNNNNNNNGEHKQSSYTSGSPTPTTPTPPPPRSGVGSTCNTASSSSGFLELLLSPDKC 467

Human   189 ESM------------KEQLL-------------------VLVEWAKYIPAFCELPLDDQVALLRA 222
            :.:            .:|||                   :.|.|.|.:..|..|..:||..||:.
  Fly   468 QELIQYQVQHNTLLFPQQLLDSRLLSWEMLQETTARLLFMAVRWVKCLMPFQTLSKNDQHLLLQE 532

Human   223 HAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYA 287
            ...|..||...:.::......:|.:..|..|...:  |.::..::.:.|::..|:::..|.:|..
  Fly   533 SWKELFLLNLAQWTIPLDLTPILESPLIRERVLQD--EATQTEMKTIQEILCRFRQITPDGSEVG 595

Human   288 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMI 352
            .:|||..|.|:..||.|...::.|:.|.|..|.|::..|......|||.||||||:|::|....|
  Fly   596 CMKAIALFAPETAGLCDVQPVEMLQDQAQCILSDHVRLRYPRQATRFGRLLLLLPSLRTIRAATI 660

Human   353 EQIQFIKLFGMAKIDNLLQEM 373
            |.:.|.:..|...|..||::|
  Fly   661 EALFFKETIGNVPIARLLRDM 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNF4A	NP_000448.3	NR_DBD_HNF4A	60..135	CDD:143518	45/159 (28%)
		NR_LBD_HNF4_like	151..373	CDD:132729	70/405 (17%)
		9aaTAD. /evidence=ECO:0000269|PubMed:30468856	368..376		3/6 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..447
dsf	NP_477140.1	NR_DBD_TLX	5..98	CDD:143537	45/84 (54%)
		NR_LBD_Tlx_PNR_like	467..671	CDD:132748	52/205 (25%)