Protein Alignment HNF4A and hnf4a

DIOPT Version :10

• Sequence 1: NP_000448.3
• Gene: HNF4A / 3172
• HGNCID: 5024
• Length: 474
• Species: Homo sapiens
• Sequence 2: XP_021325423.2
• Gene: hnf4a / 322358
• ZFINID: ZDB-GENE-030131-1077
• Length: 468
• Species: Danio rerio
• Alignment Length: 479
• Identity: 383/479 - (79%)
• Similarity: 420/479 - (87%)
• Gaps: 16/479 - (3%)

Human     1 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGD 65
            |||||.||||:|||||.|||||||||||||:|||.|..|:||.|..|:||.|.||...|||||||
Zfish     1 MRLSKPLVDMEMADYSEALDPAYTTLEFENMQVLAMSTDSSPQESANMNAANHLGAGTLCAICGD 65

Human    66 RATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKE-- 128
            |||||||||||||||||||||||||||||||||:|||:|||||||||||||||||||||||||
Zfish    66 RATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFNRQCIVDKDKRNQCRYCRLKKCFRAGMKKEVI 130

Human   129 ---AVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCES 190
               |||||||||||||||||||||||||||:||:||||||:||...:|||||.||:|:|.|||||
Zfish   131 SSSAVQNERDRISTRRSSYEDSSLPSINALIQADVLSRQISSPGPILNGDIRTKKVAAIMDVCES 195

Human   191 MKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHC 255
            ||:||||||||||||||||:||||||||||||||||||||||.||||::||:||||||:|:||:|
Zfish   196 MKQQLLVLVEWAKYIPAFCDLPLDDQVALLRAHAGEHLLLGAAKRSMMYKDILLLGNDHIIPRNC 260

Human   256 PELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLE 320
            ||| |:|||::|||||||||||:|||||||||.||||:||||||||||||.||||:|.|||||||
Zfish   261 PEL-EVSRVAVRILDELVLPFQDLQIDDNEYACLKAIVFFDPDAKGLSDPSKIKRMRYQVQVSLE 324

Human   321 DYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHA 385
            |||||||||||||||||||||||||||||||||||||:||||||||||||||||||||.::||||
Zfish   325 DYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMAKIDNLLQEMLLGGSANEAPHA 389

Human   386 HHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLP 450
            ||.|||||:|||:..||||...|.|.|.||||          :|||||.||||..|||:.||:..
Zfish   390 HHSLHPHLVQEHLSNNVIVTANMATPLHNGQM----------STPETPIPSPPTASGSDHYKMAS 444

Human   451 GAVATIVKPLSAIPQPTITKQEVI 474
            |.:||:.|..|:||||||||||.|
Zfish   445 GVIATVPKQPSSIPQPTITKQEAI 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNF4A	NP_000448.3	NR_DBD_HNF4A	60..135	CDD:143518	72/79 (91%)
		NR_LBD_HNF4_like	151..373	CDD:132729	190/221 (86%)
		9aaTAD. /evidence=ECO:0000269|PubMed:30468856	368..376		7/7 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..447		12/27 (44%)
hnf4a	XP_021325423.2	None